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Familial atypical multiple mole melanoma syndrome in an adult Indian male-case report and literature review.

Raj RC, Patil R - Indian J Dermatol (2015 Mar-Apr)

Bottom Line: It is known to be associated with carcinoma of pancreas and other malignancies involving gastrointestinal tract, breast, lung, larynx, and skin in the kindred.His father had died of carcinoma of lung and his sister had a partial phenotypic expression.The clinical presentation of the case is discussed with review of literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Goa Medical College, Bambolim, Goa, India.

ABSTRACT
Familial atypical multiple mole melanoma syndrome (FAMMMS) is an autosomal dominant genodermatosis characterized by multiple melanocytic nevi, usually more than 50, and a family history of melanoma. It is known to be associated with carcinoma of pancreas and other malignancies involving gastrointestinal tract, breast, lung, larynx, and skin in the kindred. There is no published report of FAMMMS in dark-skinned individuals. We report a case of FAMMMS in a dark-skinned adult Indian male, who had multiple extensive nevi all over the body and oral mucosa; associated with malignant melanoma, squamous cell carcinoma (Marjolin's ulcer), and carcinoma of pancreas. His father had died of carcinoma of lung and his sister had a partial phenotypic expression. The clinical presentation of the case is discussed with review of literature.

No MeSH data available.


Related in: MedlinePlus

Amelanotic melanoma on lateral aspect of thigh
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Related In: Results  -  Collection

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Figure 1: Amelanotic melanoma on lateral aspect of thigh

Mentions: A 42-year-old man presented with a rapidly proliferating painless growth on the lateral aspect of right thigh over 4 months duration [Figure 1]. He had a 4 × 5 cm irregular, brownish, proliferative growth arising from the skin, free of underlying muscles. There were two right inguinal lymph nodes less than 1cm size. Another ulcerative growth was found over the medial malleolus on the left leg with raised edges at the site of old burns scar.[Figure 2] Patient had more than 100 nevi all over the body and oral cavity brown-black in color, with irregular borders and variegated appearance [Figures 3 and 4]. There was extensive actinic damage of the scalp and facial skin. FAMMMS was clinically suspected as the patient had multiple atypical moles on the skin and mucosa along with two distinct proliferative skin malignancies.


Familial atypical multiple mole melanoma syndrome in an adult Indian male-case report and literature review.

Raj RC, Patil R - Indian J Dermatol (2015 Mar-Apr)

Amelanotic melanoma on lateral aspect of thigh
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372964&req=5

Figure 1: Amelanotic melanoma on lateral aspect of thigh
Mentions: A 42-year-old man presented with a rapidly proliferating painless growth on the lateral aspect of right thigh over 4 months duration [Figure 1]. He had a 4 × 5 cm irregular, brownish, proliferative growth arising from the skin, free of underlying muscles. There were two right inguinal lymph nodes less than 1cm size. Another ulcerative growth was found over the medial malleolus on the left leg with raised edges at the site of old burns scar.[Figure 2] Patient had more than 100 nevi all over the body and oral cavity brown-black in color, with irregular borders and variegated appearance [Figures 3 and 4]. There was extensive actinic damage of the scalp and facial skin. FAMMMS was clinically suspected as the patient had multiple atypical moles on the skin and mucosa along with two distinct proliferative skin malignancies.

Bottom Line: It is known to be associated with carcinoma of pancreas and other malignancies involving gastrointestinal tract, breast, lung, larynx, and skin in the kindred.His father had died of carcinoma of lung and his sister had a partial phenotypic expression.The clinical presentation of the case is discussed with review of literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Goa Medical College, Bambolim, Goa, India.

ABSTRACT
Familial atypical multiple mole melanoma syndrome (FAMMMS) is an autosomal dominant genodermatosis characterized by multiple melanocytic nevi, usually more than 50, and a family history of melanoma. It is known to be associated with carcinoma of pancreas and other malignancies involving gastrointestinal tract, breast, lung, larynx, and skin in the kindred. There is no published report of FAMMMS in dark-skinned individuals. We report a case of FAMMMS in a dark-skinned adult Indian male, who had multiple extensive nevi all over the body and oral mucosa; associated with malignant melanoma, squamous cell carcinoma (Marjolin's ulcer), and carcinoma of pancreas. His father had died of carcinoma of lung and his sister had a partial phenotypic expression. The clinical presentation of the case is discussed with review of literature.

No MeSH data available.


Related in: MedlinePlus