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Rowell's Syndrome to ds-DNA Negative Lupus Nephritis: A Yet Unreported Progression.

Bhobe MR, Tambe S, Jindal S, Jerajani HR - Indian J Dermatol (2015 Mar-Apr)

Bottom Line: Here we describe a case of Rowell's syndrome in an 18-year-old female who was found to be ds-DNA negative, who later progressed to develop stage V lupus nephritis (LN) over a course of 4 months.Although extremely rare, most cases of LN are drug induced.Of only seven cases of non-drug induced LN with negative dsDNA, none had cutaneous involvement.

View Article: PubMed Central - PubMed

Affiliation: Department of Skin and VD, MGM Medical College, Navi Mumbai, India.

ABSTRACT
Rowell's syndrome is now identified as a subtype of subacute lupus erythematosus (LE) with erythema multiforme-like skin lesions, positive serum rheumatoid factor, anti-Ro La positivity and speckled pattern of antinuclear antibodies. Here we describe a case of Rowell's syndrome in an 18-year-old female who was found to be ds-DNA negative, who later progressed to develop stage V lupus nephritis (LN) over a course of 4 months. Although extremely rare, most cases of LN are drug induced. Of only seven cases of non-drug induced LN with negative dsDNA, none had cutaneous involvement. Ours was a unique case of progression of Rowells syndrome to ds-DNA negative LN.

No MeSH data available.


Related in: MedlinePlus

Crusting erosions and edema were seen over lips
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Figure 3: Crusting erosions and edema were seen over lips

Mentions: Cutaneous examination revealed lesions over face, forearms, chest and lips. Lesions over the face are in the form of palpable purpura, scars and targetoid lesions [Figure 1a and b]. Purpuric and targetoid lesions were also seen over the arms [Figure 2a] and chest. Non-tender erythematous macules and targetoid lesions were seen over palms [Figure 2b]. Crusting erosions and edema were seen over lips [Figure 3]. Hair over the frontal area was sparse and brittle. Nail-fold capillaroscopy revealed proximal nail fold erythema, ragged cuticles, and capillary telangiectasia and nail-fold infarcts [Figure 4a–c].


Rowell's Syndrome to ds-DNA Negative Lupus Nephritis: A Yet Unreported Progression.

Bhobe MR, Tambe S, Jindal S, Jerajani HR - Indian J Dermatol (2015 Mar-Apr)

Crusting erosions and edema were seen over lips
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372952&req=5

Figure 3: Crusting erosions and edema were seen over lips
Mentions: Cutaneous examination revealed lesions over face, forearms, chest and lips. Lesions over the face are in the form of palpable purpura, scars and targetoid lesions [Figure 1a and b]. Purpuric and targetoid lesions were also seen over the arms [Figure 2a] and chest. Non-tender erythematous macules and targetoid lesions were seen over palms [Figure 2b]. Crusting erosions and edema were seen over lips [Figure 3]. Hair over the frontal area was sparse and brittle. Nail-fold capillaroscopy revealed proximal nail fold erythema, ragged cuticles, and capillary telangiectasia and nail-fold infarcts [Figure 4a–c].

Bottom Line: Here we describe a case of Rowell's syndrome in an 18-year-old female who was found to be ds-DNA negative, who later progressed to develop stage V lupus nephritis (LN) over a course of 4 months.Although extremely rare, most cases of LN are drug induced.Of only seven cases of non-drug induced LN with negative dsDNA, none had cutaneous involvement.

View Article: PubMed Central - PubMed

Affiliation: Department of Skin and VD, MGM Medical College, Navi Mumbai, India.

ABSTRACT
Rowell's syndrome is now identified as a subtype of subacute lupus erythematosus (LE) with erythema multiforme-like skin lesions, positive serum rheumatoid factor, anti-Ro La positivity and speckled pattern of antinuclear antibodies. Here we describe a case of Rowell's syndrome in an 18-year-old female who was found to be ds-DNA negative, who later progressed to develop stage V lupus nephritis (LN) over a course of 4 months. Although extremely rare, most cases of LN are drug induced. Of only seven cases of non-drug induced LN with negative dsDNA, none had cutaneous involvement. Ours was a unique case of progression of Rowells syndrome to ds-DNA negative LN.

No MeSH data available.


Related in: MedlinePlus