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Peripheral T cell lymphoma: not otherwise specified.

Pai AH, George A, Adiga D, Girisha BS - Indian J Dermatol (2015 Mar-Apr)

Bottom Line: Peripheral T cell lymphoma (PTCL) is a heterogeneous group of hematological tumors originating from mature T cells, which constitutes less than 15% of all non-Hodgkins lymphomas in adults.Primary cutaneous PTCL-not otherwise specified (NOS) represent a subgroup of PTCLs with no consistent immunophenotypic, genetic or clinical features.PTCL-NOS frequently has an aggressive course with a tendency for systemic involvement, however, a well-defined therapeutic and prognostic approach has not been outlined yet.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.

ABSTRACT
Peripheral T cell lymphoma (PTCL) is a heterogeneous group of hematological tumors originating from mature T cells, which constitutes less than 15% of all non-Hodgkins lymphomas in adults. Primary cutaneous PTCL-not otherwise specified (NOS) represent a subgroup of PTCLs with no consistent immunophenotypic, genetic or clinical features. PTCL-NOS frequently has an aggressive course with a tendency for systemic involvement, however, a well-defined therapeutic and prognostic approach has not been outlined yet. We report a case of PTCL-NOS with multiple cutaneous lesions in a young adult male with an emphasis on the treatment modality used.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph showing hyperkeratosis, epidermal atrophy with dense infiltration by atypical lymphocytes in the upper dermis. Mild epidermotropism present (H and E, ×100)
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Figure 3: Photomicrograph showing hyperkeratosis, epidermal atrophy with dense infiltration by atypical lymphocytes in the upper dermis. Mild epidermotropism present (H and E, ×100)

Mentions: Histopathological examination revealed hyperkeratosis, epidermal atrophy with vacuolar degeneration of basal keratinocytes and melanin incontinence into the dermis [Figure 3]. Dense infiltration by atypical lymphocytes with hyperchromatic nuclei and folded nuclear membrane were seen in the upper dermis [Figure 4]. Numerous ectatic blood vessels were present amidst the lymphoid infiltrate. Mild epidermotropism was present. These features were suggestive of cutaneous T cell lymphoma. Further immunohistochemical analysis by flow cytometry confirmed it to be PTCL-NOS, as the tumor cells expressed CD3, CD2, CD5 and CD4 and were immunonegative for CD20, CD8 and CD30. Mib-1 labeling index was <5%. To rule out systemic involvement computed tomographic scans of neck, chest and abdomen were carried out, which showed normal study with no evidence of enlarged lymph nodes.


Peripheral T cell lymphoma: not otherwise specified.

Pai AH, George A, Adiga D, Girisha BS - Indian J Dermatol (2015 Mar-Apr)

Photomicrograph showing hyperkeratosis, epidermal atrophy with dense infiltration by atypical lymphocytes in the upper dermis. Mild epidermotropism present (H and E, ×100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372951&req=5

Figure 3: Photomicrograph showing hyperkeratosis, epidermal atrophy with dense infiltration by atypical lymphocytes in the upper dermis. Mild epidermotropism present (H and E, ×100)
Mentions: Histopathological examination revealed hyperkeratosis, epidermal atrophy with vacuolar degeneration of basal keratinocytes and melanin incontinence into the dermis [Figure 3]. Dense infiltration by atypical lymphocytes with hyperchromatic nuclei and folded nuclear membrane were seen in the upper dermis [Figure 4]. Numerous ectatic blood vessels were present amidst the lymphoid infiltrate. Mild epidermotropism was present. These features were suggestive of cutaneous T cell lymphoma. Further immunohistochemical analysis by flow cytometry confirmed it to be PTCL-NOS, as the tumor cells expressed CD3, CD2, CD5 and CD4 and were immunonegative for CD20, CD8 and CD30. Mib-1 labeling index was <5%. To rule out systemic involvement computed tomographic scans of neck, chest and abdomen were carried out, which showed normal study with no evidence of enlarged lymph nodes.

Bottom Line: Peripheral T cell lymphoma (PTCL) is a heterogeneous group of hematological tumors originating from mature T cells, which constitutes less than 15% of all non-Hodgkins lymphomas in adults.Primary cutaneous PTCL-not otherwise specified (NOS) represent a subgroup of PTCLs with no consistent immunophenotypic, genetic or clinical features.PTCL-NOS frequently has an aggressive course with a tendency for systemic involvement, however, a well-defined therapeutic and prognostic approach has not been outlined yet.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.

ABSTRACT
Peripheral T cell lymphoma (PTCL) is a heterogeneous group of hematological tumors originating from mature T cells, which constitutes less than 15% of all non-Hodgkins lymphomas in adults. Primary cutaneous PTCL-not otherwise specified (NOS) represent a subgroup of PTCLs with no consistent immunophenotypic, genetic or clinical features. PTCL-NOS frequently has an aggressive course with a tendency for systemic involvement, however, a well-defined therapeutic and prognostic approach has not been outlined yet. We report a case of PTCL-NOS with multiple cutaneous lesions in a young adult male with an emphasis on the treatment modality used.

No MeSH data available.


Related in: MedlinePlus