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Thalidomide in dermatology: revisited.

Hassan I, Dorjay K, Anwar P - Indian J Dermatol (2015 Mar-Apr)

Bottom Line: The use of thalidomide in relation to dermatology is well- known and enough data is available in the literature about various aspects of thalidomide.Despite being an interesting and useful drug for many dermatoses, it is associated with many health hazards including the birth defects, phocomelia.We hereby present a comprehensive review about thalidomide and its application in dermatology.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, STD and Leprosy, Government Medical College, Srinagar, Jammu and Kashmir, India.

ABSTRACT
The use of thalidomide in relation to dermatology is well- known and enough data is available in the literature about various aspects of thalidomide. Despite being an interesting and useful drug for many dermatoses, it is associated with many health hazards including the birth defects, phocomelia. We hereby present a comprehensive review about thalidomide and its application in dermatology.

No MeSH data available.


Related in: MedlinePlus

Molecular structure of thalidomide
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Figure 1: Molecular structure of thalidomide

Mentions: Thalidomide is a synthetic derivative of glutamic acid with one chiral center and consists of a glutarimide ring and a pthalidimide ring.[3] The pthalidimide ring is thought to be responsible for the teratogenic effects whereas the glutarimide ring, which is structurally similar to other sedatives, mediates sedation. Its international union of pure and applied chemistry (IUPAC) name is (2-[2,6-dioxo-3piperidyl] isoindoline-1, 3 dione) and chemical formula C13H10N2O4, having a molecular mass 258.23g/mol3. The molecular structure is shown in Figure 1.


Thalidomide in dermatology: revisited.

Hassan I, Dorjay K, Anwar P - Indian J Dermatol (2015 Mar-Apr)

Molecular structure of thalidomide
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372942&req=5

Figure 1: Molecular structure of thalidomide
Mentions: Thalidomide is a synthetic derivative of glutamic acid with one chiral center and consists of a glutarimide ring and a pthalidimide ring.[3] The pthalidimide ring is thought to be responsible for the teratogenic effects whereas the glutarimide ring, which is structurally similar to other sedatives, mediates sedation. Its international union of pure and applied chemistry (IUPAC) name is (2-[2,6-dioxo-3piperidyl] isoindoline-1, 3 dione) and chemical formula C13H10N2O4, having a molecular mass 258.23g/mol3. The molecular structure is shown in Figure 1.

Bottom Line: The use of thalidomide in relation to dermatology is well- known and enough data is available in the literature about various aspects of thalidomide.Despite being an interesting and useful drug for many dermatoses, it is associated with many health hazards including the birth defects, phocomelia.We hereby present a comprehensive review about thalidomide and its application in dermatology.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, STD and Leprosy, Government Medical College, Srinagar, Jammu and Kashmir, India.

ABSTRACT
The use of thalidomide in relation to dermatology is well- known and enough data is available in the literature about various aspects of thalidomide. Despite being an interesting and useful drug for many dermatoses, it is associated with many health hazards including the birth defects, phocomelia. We hereby present a comprehensive review about thalidomide and its application in dermatology.

No MeSH data available.


Related in: MedlinePlus