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Sacroiliac indicis increase the specificity of bone scintigraphy in the diagnosis of sacroiliitis.

Koç ZP, Kin Cengiz A, Aydın F, Samancı N, Yazısız V, Koca SS, Karayalçın B - Mol Imaging Radionucl Ther (2015)

Bottom Line: There was no significant interobserver difference (p>0.05).There were 8 false positive results in other 30 patients.There was significant correlation between the observers calculated indicis (p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Akdeniz University Faculty of Medicine Hospital, Clinic of Nuclear Medicine, Antalya, Turkey. E-mail: bkarayalcin@gmail.com.

ABSTRACT

Objective: Bone scintigraphy is a highly sensitive method in the evaluation of sacroiliitis. Aim of this study is firstly to evaluate interobserver variation of partial and whole sacroiliac indicis, secondly investigation of clinical importance of these indicis in the diagnosis of sacroiliitis.

Methods: Fourty-six subjects (24 female: 35.4±11.9; 22 male: 43.1±12.4) without sacroiliitis 45 subjects with low back pain (33 female: 43.3±11.5, 11 male: 35.5±17.2) were included in the study. For right (R) and left (L) whole indices (WSI) irregular region of interest (ROI), for partial indices superior (S) and inferior (I) rectangular ROI were used. For background activity, rectangular ROI was drawn from the sacral region. Indices were calculated from ratio of average counts of sacroiliac and background regions. Two independent observers calculated sacroiliac indices. Interobserver agreement was evaluated by Pearson analysis.

Results: There was no significant interobserver difference (p>0.05). Significant correlation existed between all calculated indices. Among 45 patients with suspicion of sacroiliitis 15 had final diagnosis of sacroiliitis and all of the Tc-99m methilenediphosphonate planar and SPECT bone scintigraphy results of these patients were concordant with sacroiliitis. There were 8 false positive results in other 30 patients. Seven of these eight patients had normal index values. If the scintigraphy would be evaluated in conjuction with indicis the specificity would increase from 73% to 97% but sensitivity decreases from 100% to 80%. There was significant correlation between the observers calculated indicis (p<0.001).

Conclusion: Superior and inferior sacroiliac index values can be used with confidence. If we use sacroiliac index values to confirm positive results; index values can increase the specificity of bone scintigraphy.

No MeSH data available.


Related in: MedlinePlus

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Mentions: Quantification: Irregular region of interest (ROI) for right (R) and left (L) whole sacroiliac indices (WSI) (Figure 1) and rectangular ROI (15x15 pixel) for superior (S) and inferior (I) partial indices (PI) were applied (Figure 2). All of the indices are calculated as the ratio of average counts of whole and partial sacroiliac regions to background region. Index measurements were performed by two independent observers. The values of the patients higher than the maximum index values according to gender shown in Table 1 was considered positive for sacroiliitis. Interpretation of index values was performed according to our own index values obtained from control studies. Additional quantitative analysis for SPECT images was not performed.


Sacroiliac indicis increase the specificity of bone scintigraphy in the diagnosis of sacroiliitis.

Koç ZP, Kin Cengiz A, Aydın F, Samancı N, Yazısız V, Koca SS, Karayalçın B - Mol Imaging Radionucl Ther (2015)

Partial region of interests
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372772&req=5

f2: Partial region of interests
Mentions: Quantification: Irregular region of interest (ROI) for right (R) and left (L) whole sacroiliac indices (WSI) (Figure 1) and rectangular ROI (15x15 pixel) for superior (S) and inferior (I) partial indices (PI) were applied (Figure 2). All of the indices are calculated as the ratio of average counts of whole and partial sacroiliac regions to background region. Index measurements were performed by two independent observers. The values of the patients higher than the maximum index values according to gender shown in Table 1 was considered positive for sacroiliitis. Interpretation of index values was performed according to our own index values obtained from control studies. Additional quantitative analysis for SPECT images was not performed.

Bottom Line: There was no significant interobserver difference (p>0.05).There were 8 false positive results in other 30 patients.There was significant correlation between the observers calculated indicis (p<0.001).

View Article: PubMed Central - PubMed

Affiliation: Akdeniz University Faculty of Medicine Hospital, Clinic of Nuclear Medicine, Antalya, Turkey. E-mail: bkarayalcin@gmail.com.

ABSTRACT

Objective: Bone scintigraphy is a highly sensitive method in the evaluation of sacroiliitis. Aim of this study is firstly to evaluate interobserver variation of partial and whole sacroiliac indicis, secondly investigation of clinical importance of these indicis in the diagnosis of sacroiliitis.

Methods: Fourty-six subjects (24 female: 35.4±11.9; 22 male: 43.1±12.4) without sacroiliitis 45 subjects with low back pain (33 female: 43.3±11.5, 11 male: 35.5±17.2) were included in the study. For right (R) and left (L) whole indices (WSI) irregular region of interest (ROI), for partial indices superior (S) and inferior (I) rectangular ROI were used. For background activity, rectangular ROI was drawn from the sacral region. Indices were calculated from ratio of average counts of sacroiliac and background regions. Two independent observers calculated sacroiliac indices. Interobserver agreement was evaluated by Pearson analysis.

Results: There was no significant interobserver difference (p>0.05). Significant correlation existed between all calculated indices. Among 45 patients with suspicion of sacroiliitis 15 had final diagnosis of sacroiliitis and all of the Tc-99m methilenediphosphonate planar and SPECT bone scintigraphy results of these patients were concordant with sacroiliitis. There were 8 false positive results in other 30 patients. Seven of these eight patients had normal index values. If the scintigraphy would be evaluated in conjuction with indicis the specificity would increase from 73% to 97% but sensitivity decreases from 100% to 80%. There was significant correlation between the observers calculated indicis (p<0.001).

Conclusion: Superior and inferior sacroiliac index values can be used with confidence. If we use sacroiliac index values to confirm positive results; index values can increase the specificity of bone scintigraphy.

No MeSH data available.


Related in: MedlinePlus