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Blood flow in intracranial aneurysms treated with Pipeline embolization devices: computational simulation and verification with Doppler ultrasonography on phantom models.

Tsang AC, Lai SS, Chung WC, Tang AY, Leung GK, Poon AK, Yu AC, Chow KW - Ultrasonography (2015)

Bottom Line: Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.

ABSTRACT

Purpose: The aim of this study was to validate a computational fluid dynamics (CFD) simulation of flow-diverter treatment through Doppler ultrasonography measurements in patient-specific models of intracranial bifurcation and side-wall aneurysms.

Methods: Computational and physical models of patient-specific bifurcation and sidewall aneurysms were constructed from computed tomography angiography with use of stereolithography, a three-dimensional printing technology. Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.

Results: CFD simulations showed drastic flow reduction after flow-diverter treatment in both aneurysms. The mean volume flow rate decreased by 90% and 85% for the bifurcation aneurysm and the side-wall aneurysm, respectively. Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.

Conclusion: The CFD estimation of flow reduction in aneurysms treated with a flow-diverting stent was verified by Doppler ultrasonography in patient-specific phantom models of bifurcation and side-wall aneurysms. The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.

No MeSH data available.


Related in: MedlinePlus

Diagram of the experimental setup. The physical phantom models were mounted on a custom-made clear acrylic casing. They were connected to a circuit simulating the internal carotid artery circulation with pulsatile flow at 120/80 mm Hg generated by a computer-controlled gear pump.
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f2-usg-14063: Diagram of the experimental setup. The physical phantom models were mounted on a custom-made clear acrylic casing. They were connected to a circuit simulating the internal carotid artery circulation with pulsatile flow at 120/80 mm Hg generated by a computer-controlled gear pump.

Mentions: A single appropriately-sized PED was deployed across the aneurysm neck in both aneurysm models using the procedures employed in a standard surgical operation. In patient 1, the posterior communicating artery was covered by the PED. In patient 2, only the aneurysm was covered. The models were mounted on a custommade clear acrylic casing and aligned to prevent geometric error (Fig. 2). These were connected to a circuit that simulated ICA circulation with pulsatile flow at 120/80 mm Hg generated by a computercontrolled gear pump (AccuFlow-Q, Shelley Medical Imaging, London, ON, Canada). A blood-mimicking fluid with acoustic scattering strength and acoustic speed of 1,548 m/sec (Shelley Medical Imaging) was used as the flow medium [16].


Blood flow in intracranial aneurysms treated with Pipeline embolization devices: computational simulation and verification with Doppler ultrasonography on phantom models.

Tsang AC, Lai SS, Chung WC, Tang AY, Leung GK, Poon AK, Yu AC, Chow KW - Ultrasonography (2015)

Diagram of the experimental setup. The physical phantom models were mounted on a custom-made clear acrylic casing. They were connected to a circuit simulating the internal carotid artery circulation with pulsatile flow at 120/80 mm Hg generated by a computer-controlled gear pump.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372715&req=5

f2-usg-14063: Diagram of the experimental setup. The physical phantom models were mounted on a custom-made clear acrylic casing. They were connected to a circuit simulating the internal carotid artery circulation with pulsatile flow at 120/80 mm Hg generated by a computer-controlled gear pump.
Mentions: A single appropriately-sized PED was deployed across the aneurysm neck in both aneurysm models using the procedures employed in a standard surgical operation. In patient 1, the posterior communicating artery was covered by the PED. In patient 2, only the aneurysm was covered. The models were mounted on a custommade clear acrylic casing and aligned to prevent geometric error (Fig. 2). These were connected to a circuit that simulated ICA circulation with pulsatile flow at 120/80 mm Hg generated by a computercontrolled gear pump (AccuFlow-Q, Shelley Medical Imaging, London, ON, Canada). A blood-mimicking fluid with acoustic scattering strength and acoustic speed of 1,548 m/sec (Shelley Medical Imaging) was used as the flow medium [16].

Bottom Line: Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.

ABSTRACT

Purpose: The aim of this study was to validate a computational fluid dynamics (CFD) simulation of flow-diverter treatment through Doppler ultrasonography measurements in patient-specific models of intracranial bifurcation and side-wall aneurysms.

Methods: Computational and physical models of patient-specific bifurcation and sidewall aneurysms were constructed from computed tomography angiography with use of stereolithography, a three-dimensional printing technology. Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.

Results: CFD simulations showed drastic flow reduction after flow-diverter treatment in both aneurysms. The mean volume flow rate decreased by 90% and 85% for the bifurcation aneurysm and the side-wall aneurysm, respectively. Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.

Conclusion: The CFD estimation of flow reduction in aneurysms treated with a flow-diverting stent was verified by Doppler ultrasonography in patient-specific phantom models of bifurcation and side-wall aneurysms. The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.

No MeSH data available.


Related in: MedlinePlus