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Blood flow in intracranial aneurysms treated with Pipeline embolization devices: computational simulation and verification with Doppler ultrasonography on phantom models.

Tsang AC, Lai SS, Chung WC, Tang AY, Leung GK, Poon AK, Yu AC, Chow KW - Ultrasonography (2015)

Bottom Line: Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.

ABSTRACT

Purpose: The aim of this study was to validate a computational fluid dynamics (CFD) simulation of flow-diverter treatment through Doppler ultrasonography measurements in patient-specific models of intracranial bifurcation and side-wall aneurysms.

Methods: Computational and physical models of patient-specific bifurcation and sidewall aneurysms were constructed from computed tomography angiography with use of stereolithography, a three-dimensional printing technology. Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.

Results: CFD simulations showed drastic flow reduction after flow-diverter treatment in both aneurysms. The mean volume flow rate decreased by 90% and 85% for the bifurcation aneurysm and the side-wall aneurysm, respectively. Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.

Conclusion: The CFD estimation of flow reduction in aneurysms treated with a flow-diverting stent was verified by Doppler ultrasonography in patient-specific phantom models of bifurcation and side-wall aneurysms. The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.

No MeSH data available.


Related in: MedlinePlus

Two intracranial aneurysms and the corresponding phantom models.A, B. Computed tomography angiograms illustrate the configurations of a posterior communicating artery aneurysm in a 60-year-old woman (patient 1) (A) and a distal internal carotid artery aneurysm in a 71-year-old woman (patient 2) (B). C-F. These angiograms were used to generate computational fluid dynamics models (C, D) and physical phantom models (E, F). ICA, internal carotid artery; MCA, middle cerebral artery; PComA, posterior communicating artery.
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f1-usg-14063: Two intracranial aneurysms and the corresponding phantom models.A, B. Computed tomography angiograms illustrate the configurations of a posterior communicating artery aneurysm in a 60-year-old woman (patient 1) (A) and a distal internal carotid artery aneurysm in a 71-year-old woman (patient 2) (B). C-F. These angiograms were used to generate computational fluid dynamics models (C, D) and physical phantom models (E, F). ICA, internal carotid artery; MCA, middle cerebral artery; PComA, posterior communicating artery.

Mentions: This study, involving two patients with cerebral aneurysms, was approved by the Institutional Review Board of the University of Hong Kong and Queen Mary Hospital. Consent of the patients was obtained. Patient 1 had a bifurcation aneurysm at the posterior communicating artery (Fig. 1A). Patient 2 had a side-wall aneurysm located at the distal internal carotid artery (ICA) (Fig. 1B). Geometrically accurate three-dimensional computational models were reconstructed from computed tomography (CT) angiography with Mimics (Materialise, Leuven, Belgium) for CFD analysis (Fig. 1C, D).


Blood flow in intracranial aneurysms treated with Pipeline embolization devices: computational simulation and verification with Doppler ultrasonography on phantom models.

Tsang AC, Lai SS, Chung WC, Tang AY, Leung GK, Poon AK, Yu AC, Chow KW - Ultrasonography (2015)

Two intracranial aneurysms and the corresponding phantom models.A, B. Computed tomography angiograms illustrate the configurations of a posterior communicating artery aneurysm in a 60-year-old woman (patient 1) (A) and a distal internal carotid artery aneurysm in a 71-year-old woman (patient 2) (B). C-F. These angiograms were used to generate computational fluid dynamics models (C, D) and physical phantom models (E, F). ICA, internal carotid artery; MCA, middle cerebral artery; PComA, posterior communicating artery.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372715&req=5

f1-usg-14063: Two intracranial aneurysms and the corresponding phantom models.A, B. Computed tomography angiograms illustrate the configurations of a posterior communicating artery aneurysm in a 60-year-old woman (patient 1) (A) and a distal internal carotid artery aneurysm in a 71-year-old woman (patient 2) (B). C-F. These angiograms were used to generate computational fluid dynamics models (C, D) and physical phantom models (E, F). ICA, internal carotid artery; MCA, middle cerebral artery; PComA, posterior communicating artery.
Mentions: This study, involving two patients with cerebral aneurysms, was approved by the Institutional Review Board of the University of Hong Kong and Queen Mary Hospital. Consent of the patients was obtained. Patient 1 had a bifurcation aneurysm at the posterior communicating artery (Fig. 1A). Patient 2 had a side-wall aneurysm located at the distal internal carotid artery (ICA) (Fig. 1B). Geometrically accurate three-dimensional computational models were reconstructed from computed tomography (CT) angiography with Mimics (Materialise, Leuven, Belgium) for CFD analysis (Fig. 1C, D).

Bottom Line: Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.

ABSTRACT

Purpose: The aim of this study was to validate a computational fluid dynamics (CFD) simulation of flow-diverter treatment through Doppler ultrasonography measurements in patient-specific models of intracranial bifurcation and side-wall aneurysms.

Methods: Computational and physical models of patient-specific bifurcation and sidewall aneurysms were constructed from computed tomography angiography with use of stereolithography, a three-dimensional printing technology. Flow dynamics parameters before and after flow-diverter treatment were measured with pulse-wave and color Doppler ultrasonography, and then compared with CFD simulations.

Results: CFD simulations showed drastic flow reduction after flow-diverter treatment in both aneurysms. The mean volume flow rate decreased by 90% and 85% for the bifurcation aneurysm and the side-wall aneurysm, respectively. Velocity contour plots from computer simulations before and after flow diversion closely resembled the patterns obtained by color Doppler ultrasonography.

Conclusion: The CFD estimation of flow reduction in aneurysms treated with a flow-diverting stent was verified by Doppler ultrasonography in patient-specific phantom models of bifurcation and side-wall aneurysms. The combination of CFD and ultrasonography may constitute a feasible and reliable technique in studying the treatment of intracranial aneurysms with flow-diverting stents.

No MeSH data available.


Related in: MedlinePlus