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Photoacoustic imaging platforms for multimodal imaging.

Kim J, Lee D, Jung U, Kim C - Ultrasonography (2015)

Bottom Line: Photoacoustic (PA) imaging is a hybrid biomedical imaging method that exploits both acoustical Epub ahead of print and optical properties and can provide both functional and structural information.Therefore, PA imaging can complement other imaging methods, such as ultrasound imaging, fluorescence imaging, optical coherence tomography, and multi-photon microscopy.This article reviews techniques that integrate PA with the above imaging methods and describes their applications.

View Article: PubMed Central - PubMed

Affiliation: Departments of Electrical Engineering, Pohang University of Science and Technology, Pohang, Korea.

ABSTRACT
Photoacoustic (PA) imaging is a hybrid biomedical imaging method that exploits both acoustical Epub ahead of print and optical properties and can provide both functional and structural information. Therefore, PA imaging can complement other imaging methods, such as ultrasound imaging, fluorescence imaging, optical coherence tomography, and multi-photon microscopy. This article reviews techniques that integrate PA with the above imaging methods and describes their applications.

No MeSH data available.


Experimental setup of PAM/OCT imaging system and example image.A. A tunable dye laser excites the target, and an unfocused needle transducer detects PA waves. A conventional spectral domain OCT system with broadband laser source, spectrometer and a line CCD camera are used to detect the interference signal in the spectral domain. The dichroic mirror combines the pulsed laser beam in the PAM system with the broadband laser beam in the OCT system. The two-dimensional galvanometer is used for raster scanning. B. Maximum amplitude projection PAM image of retinal vasculatures. Scale bar=500 µm. PD, photodiode; APD, avalanche photodetector; BS, beam splitter; Nd:YAG, neodymium-doped yttrium aluminum garnet; DM, dichroic mirror; HM, hot mirror; SLD, super luminescent diode; SPEC, spectrometer; GM, two-dimensional galvanometer; AMP, amplifier; UT, ultrasound transducer; RV, retina vessels; CV, choroidal vessels; PAM, photoacoustic microscopy; OCT, optical coherence tomography; PA, photoacoustic. Reprinted from Song et al. J Biomed Opt 2012;17:061206 [43], with permission of SPIE.
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f4-usg-14062: Experimental setup of PAM/OCT imaging system and example image.A. A tunable dye laser excites the target, and an unfocused needle transducer detects PA waves. A conventional spectral domain OCT system with broadband laser source, spectrometer and a line CCD camera are used to detect the interference signal in the spectral domain. The dichroic mirror combines the pulsed laser beam in the PAM system with the broadband laser beam in the OCT system. The two-dimensional galvanometer is used for raster scanning. B. Maximum amplitude projection PAM image of retinal vasculatures. Scale bar=500 µm. PD, photodiode; APD, avalanche photodetector; BS, beam splitter; Nd:YAG, neodymium-doped yttrium aluminum garnet; DM, dichroic mirror; HM, hot mirror; SLD, super luminescent diode; SPEC, spectrometer; GM, two-dimensional galvanometer; AMP, amplifier; UT, ultrasound transducer; RV, retina vessels; CV, choroidal vessels; PAM, photoacoustic microscopy; OCT, optical coherence tomography; PA, photoacoustic. Reprinted from Song et al. J Biomed Opt 2012;17:061206 [43], with permission of SPIE.

Mentions: The integrated PAM/OCT imaging system is composed of three main parts: (1) the PAM system, (2) the OCT system, and (3) a dichroic mirror and two-dimensional galvanometer for beam combining and scanning (Fig. 4A) [43,44]. In the PAM system, a tunable dye laser is used to excite the target optically, an unfocused needle transducer is used to detect PA waves, and a data acquisition board is used to digitize the data. The interference signal in the spectral domain is detected by a conventional spectral domain OCT system with a broadband laser source, spectrometer, and a line charge-coupled device camera. The dichroic mirror is used to combine the pulsed laser beam in the PAM system and the broadband laser beam in the OCT system. The two-dimensional galvanometer is used for raster scanning; it is synchronized with the data acquisition board and the OCT computer by reference to the external trigger signal from the PAM pulsed laser.


Photoacoustic imaging platforms for multimodal imaging.

Kim J, Lee D, Jung U, Kim C - Ultrasonography (2015)

Experimental setup of PAM/OCT imaging system and example image.A. A tunable dye laser excites the target, and an unfocused needle transducer detects PA waves. A conventional spectral domain OCT system with broadband laser source, spectrometer and a line CCD camera are used to detect the interference signal in the spectral domain. The dichroic mirror combines the pulsed laser beam in the PAM system with the broadband laser beam in the OCT system. The two-dimensional galvanometer is used for raster scanning. B. Maximum amplitude projection PAM image of retinal vasculatures. Scale bar=500 µm. PD, photodiode; APD, avalanche photodetector; BS, beam splitter; Nd:YAG, neodymium-doped yttrium aluminum garnet; DM, dichroic mirror; HM, hot mirror; SLD, super luminescent diode; SPEC, spectrometer; GM, two-dimensional galvanometer; AMP, amplifier; UT, ultrasound transducer; RV, retina vessels; CV, choroidal vessels; PAM, photoacoustic microscopy; OCT, optical coherence tomography; PA, photoacoustic. Reprinted from Song et al. J Biomed Opt 2012;17:061206 [43], with permission of SPIE.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372714&req=5

f4-usg-14062: Experimental setup of PAM/OCT imaging system and example image.A. A tunable dye laser excites the target, and an unfocused needle transducer detects PA waves. A conventional spectral domain OCT system with broadband laser source, spectrometer and a line CCD camera are used to detect the interference signal in the spectral domain. The dichroic mirror combines the pulsed laser beam in the PAM system with the broadband laser beam in the OCT system. The two-dimensional galvanometer is used for raster scanning. B. Maximum amplitude projection PAM image of retinal vasculatures. Scale bar=500 µm. PD, photodiode; APD, avalanche photodetector; BS, beam splitter; Nd:YAG, neodymium-doped yttrium aluminum garnet; DM, dichroic mirror; HM, hot mirror; SLD, super luminescent diode; SPEC, spectrometer; GM, two-dimensional galvanometer; AMP, amplifier; UT, ultrasound transducer; RV, retina vessels; CV, choroidal vessels; PAM, photoacoustic microscopy; OCT, optical coherence tomography; PA, photoacoustic. Reprinted from Song et al. J Biomed Opt 2012;17:061206 [43], with permission of SPIE.
Mentions: The integrated PAM/OCT imaging system is composed of three main parts: (1) the PAM system, (2) the OCT system, and (3) a dichroic mirror and two-dimensional galvanometer for beam combining and scanning (Fig. 4A) [43,44]. In the PAM system, a tunable dye laser is used to excite the target optically, an unfocused needle transducer is used to detect PA waves, and a data acquisition board is used to digitize the data. The interference signal in the spectral domain is detected by a conventional spectral domain OCT system with a broadband laser source, spectrometer, and a line charge-coupled device camera. The dichroic mirror is used to combine the pulsed laser beam in the PAM system and the broadband laser beam in the OCT system. The two-dimensional galvanometer is used for raster scanning; it is synchronized with the data acquisition board and the OCT computer by reference to the external trigger signal from the PAM pulsed laser.

Bottom Line: Photoacoustic (PA) imaging is a hybrid biomedical imaging method that exploits both acoustical Epub ahead of print and optical properties and can provide both functional and structural information.Therefore, PA imaging can complement other imaging methods, such as ultrasound imaging, fluorescence imaging, optical coherence tomography, and multi-photon microscopy.This article reviews techniques that integrate PA with the above imaging methods and describes their applications.

View Article: PubMed Central - PubMed

Affiliation: Departments of Electrical Engineering, Pohang University of Science and Technology, Pohang, Korea.

ABSTRACT
Photoacoustic (PA) imaging is a hybrid biomedical imaging method that exploits both acoustical Epub ahead of print and optical properties and can provide both functional and structural information. Therefore, PA imaging can complement other imaging methods, such as ultrasound imaging, fluorescence imaging, optical coherence tomography, and multi-photon microscopy. This article reviews techniques that integrate PA with the above imaging methods and describes their applications.

No MeSH data available.