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Prognostic value of gallbladder wall thickening in patients with acute hepatitis A.

Ahn JH, Chung JJ, Yu JS, Kim JH, Cho ES, Kim DJ - Ultrasonography (2015)

Bottom Line: Besides gamma-glutamyl transpeptidase and alkaline phosphatase, all laboratory results of group A were significantly higher than those of group B (P<0.05).No significant differences in laboratory results, hospitalization duration, and time to normalization of liver function were found between the two subgroups.In the multivariate logistic regression analysis, serum alanine transaminase, total bilirubin and albumin levels, and hospitalization duration were significantly associated with GB wall thickening in patients with hepatitis A.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To investigate the clinical significance of gallbladder (GB) wall thickening frequently observed in patients with acute hepatitis A.

Methods: A total of 328 consecutive patients who were diagnosed with acute hepatitis A and underwent abdominal ultrasonography were enrolled retrospectively. Patients were divided into two groups: GB wall thickening (≥3 mm, group A) and no thickening (group B). Group A was subdivided into two subgroups (GB wall thickening of ≥10 mm, group A-1 and ≥3 mm to <10 mm, group A-2). The laboratory results related to liver function, hospitalization duration, and time to normalization of liver function were compared between the groups.

Results: A total of 230 patients showed GB wall thickening (group A). Besides gamma-glutamyl transpeptidase and alkaline phosphatase, all laboratory results of group A were significantly higher than those of group B (P<0.05). Compared with group B, the hospitalization duration and the time to normalization of liver function were significantly longer in group A (P<0.05). Group A-1 included 146 patients and group A-2 included 84 patients. No significant differences in laboratory results, hospitalization duration, and time to normalization of liver function were found between the two subgroups. In the multivariate logistic regression analysis, serum alanine transaminase, total bilirubin and albumin levels, and hospitalization duration were significantly associated with GB wall thickening in patients with hepatitis A.

Conclusion: The presence of GB wall thickening in patients with acute hepatitis A suggests a poorer prognosis irrespective of the degree of GB wall thickening or the degree of liver enzyme elevation.

No MeSH data available.


Related in: MedlinePlus

A 24-year-old male with acute hepatitis A.Longitudinal sonogram of abdomen shows gallbladder wall thickening of about 12 mm (arrowheads).
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f1-usg-14052: A 24-year-old male with acute hepatitis A.Longitudinal sonogram of abdomen shows gallbladder wall thickening of about 12 mm (arrowheads).

Mentions: Five radiologists with 5-20 years of experience in abdominal US performed US using an IU 22 (Phillips Medical Systems, Bothell, WA, USA) with a 1-4-MHz convex transducer and an Acuson Sequoia 512 (Acuson Corporation, Mountain View, CA, USA) with a 4-MHz convex transducer. Intercostal or longitudinal US scans were used to evaluate the GB wall thickness. Measurement of the GB wall thickness was performed by two abdominal radiologists who were unaware of the laboratory information of patients. Each reader measured the thickness of the GB wall (body portion of the GB) at a workstation (Centricity 2.0, GE Healthcare). Thereafter, the measured values obtained from the two readers were averaged, and the mean value was used. On the basis of previous studies, we considered the GB wall to be thickened in fasting subjects whenever its width exceeded 3 mm (Fig. 1) [4]. Patients were divided into the following two groups: patients with GB wall thickening (group A) and those without GB wall thickening (group B). The laboratory results of the patients with GB wall thickening were compared with those of patients without GB wall thickening. The tests included aspartate aminotransferase (AST), alanine transaminase (ALT), total bilirubin, direct bilirubin, albumin, alkaline phosphatase (ALP), and gammaglutamyl transpeptidase (γ-GT) levels; prothrombin time (PT); hospitalization duration; and time to normalization of liver function.


Prognostic value of gallbladder wall thickening in patients with acute hepatitis A.

Ahn JH, Chung JJ, Yu JS, Kim JH, Cho ES, Kim DJ - Ultrasonography (2015)

A 24-year-old male with acute hepatitis A.Longitudinal sonogram of abdomen shows gallbladder wall thickening of about 12 mm (arrowheads).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372712&req=5

f1-usg-14052: A 24-year-old male with acute hepatitis A.Longitudinal sonogram of abdomen shows gallbladder wall thickening of about 12 mm (arrowheads).
Mentions: Five radiologists with 5-20 years of experience in abdominal US performed US using an IU 22 (Phillips Medical Systems, Bothell, WA, USA) with a 1-4-MHz convex transducer and an Acuson Sequoia 512 (Acuson Corporation, Mountain View, CA, USA) with a 4-MHz convex transducer. Intercostal or longitudinal US scans were used to evaluate the GB wall thickness. Measurement of the GB wall thickness was performed by two abdominal radiologists who were unaware of the laboratory information of patients. Each reader measured the thickness of the GB wall (body portion of the GB) at a workstation (Centricity 2.0, GE Healthcare). Thereafter, the measured values obtained from the two readers were averaged, and the mean value was used. On the basis of previous studies, we considered the GB wall to be thickened in fasting subjects whenever its width exceeded 3 mm (Fig. 1) [4]. Patients were divided into the following two groups: patients with GB wall thickening (group A) and those without GB wall thickening (group B). The laboratory results of the patients with GB wall thickening were compared with those of patients without GB wall thickening. The tests included aspartate aminotransferase (AST), alanine transaminase (ALT), total bilirubin, direct bilirubin, albumin, alkaline phosphatase (ALP), and gammaglutamyl transpeptidase (γ-GT) levels; prothrombin time (PT); hospitalization duration; and time to normalization of liver function.

Bottom Line: Besides gamma-glutamyl transpeptidase and alkaline phosphatase, all laboratory results of group A were significantly higher than those of group B (P<0.05).No significant differences in laboratory results, hospitalization duration, and time to normalization of liver function were found between the two subgroups.In the multivariate logistic regression analysis, serum alanine transaminase, total bilirubin and albumin levels, and hospitalization duration were significantly associated with GB wall thickening in patients with hepatitis A.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To investigate the clinical significance of gallbladder (GB) wall thickening frequently observed in patients with acute hepatitis A.

Methods: A total of 328 consecutive patients who were diagnosed with acute hepatitis A and underwent abdominal ultrasonography were enrolled retrospectively. Patients were divided into two groups: GB wall thickening (≥3 mm, group A) and no thickening (group B). Group A was subdivided into two subgroups (GB wall thickening of ≥10 mm, group A-1 and ≥3 mm to <10 mm, group A-2). The laboratory results related to liver function, hospitalization duration, and time to normalization of liver function were compared between the groups.

Results: A total of 230 patients showed GB wall thickening (group A). Besides gamma-glutamyl transpeptidase and alkaline phosphatase, all laboratory results of group A were significantly higher than those of group B (P<0.05). Compared with group B, the hospitalization duration and the time to normalization of liver function were significantly longer in group A (P<0.05). Group A-1 included 146 patients and group A-2 included 84 patients. No significant differences in laboratory results, hospitalization duration, and time to normalization of liver function were found between the two subgroups. In the multivariate logistic regression analysis, serum alanine transaminase, total bilirubin and albumin levels, and hospitalization duration were significantly associated with GB wall thickening in patients with hepatitis A.

Conclusion: The presence of GB wall thickening in patients with acute hepatitis A suggests a poorer prognosis irrespective of the degree of GB wall thickening or the degree of liver enzyme elevation.

No MeSH data available.


Related in: MedlinePlus