Limits...
Whole-organ and segmental stiffness measured with liver magnetic resonance elastography in healthy adults: significance of the region of interest.

Rusak G, Zawada E, Lemanowicz A, Serafin Z - Abdom Imaging (2015)

Bottom Line: Since the method is not well established, several different protocols were proposed that differ in results.Results of measurement within segment 8 were closest to the whole-liver method (ICC, 0.84).The most reproducible method is averaging of cross sections of the whole liver.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland.

ABSTRACT

Purpose: MR elastography (MRE) is a recent non-invasive technique that provides in vivo data on the viscoelasticity of the liver. Since the method is not well established, several different protocols were proposed that differ in results. The aim of the study was to analyze the variability of stiffness measurements in different regions of the liver.

Methods: Twenty healthy adults aged 24-45 years were recruited. The examination was performed using a mechanical excitation of 64 Hz. MRE images were fused with axial T2WI breath-hold images (thickness 10 mm, spacing 10 mm). Stiffness was measured as a mean value of each cross section of the whole liver, on a single largest cross section, in the right lobe, and in ROIs (50 pix.) placed in the center of the left lobe, segments 5/6, 7, 8, and the parahilar region.

Results: Whole-liver stiffness ranged from 1.56 to 2.75 kPa. Mean segmental stiffness differed significantly between the tested regions (range from 1.55 ± 0.28 to 2.37 ± 0.32 kPa; P < 0.0001, ANOVA). Within-method variability of measurements ranged from 14 % for whole liver and segment 8-26 % for segment 7. Within-subject variability ranged from 13 to 31 %. Results of measurement within segment 8 were closest to the whole-liver method (ICC, 0.84).

Conclusions: Stiffness of the liver presented significant variability depending on the region of measurement. The most reproducible method is averaging of cross sections of the whole liver. There was significant variability between stiffness in subjects considered healthy, which requires further investigation.

Show MeSH

Related in: MedlinePlus

Results of measurements of whole-liver and regional stiffness. The graph presents mean values and their 95 % confidence intervals.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4372679&req=5

Fig3: Results of measurements of whole-liver and regional stiffness. The graph presents mean values and their 95 % confidence intervals.

Mentions: All examinations were performed without complications, and none of them were excluded due to insufficient image quality. Liver stiffness values ranged from 1.10 to 3.08 kPa. Whole-liver stiffness ranged from 1.56 to 2.75 kPa. Mean segmental stiffness differed significantly between the tested regions (range from 1.55 ± 0.28 to 2.37 ± 0.32 kPa; P < 0.0001, ANOVA)—Fig. 3, Table 1.Fig. 3


Whole-organ and segmental stiffness measured with liver magnetic resonance elastography in healthy adults: significance of the region of interest.

Rusak G, Zawada E, Lemanowicz A, Serafin Z - Abdom Imaging (2015)

Results of measurements of whole-liver and regional stiffness. The graph presents mean values and their 95 % confidence intervals.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4372679&req=5

Fig3: Results of measurements of whole-liver and regional stiffness. The graph presents mean values and their 95 % confidence intervals.
Mentions: All examinations were performed without complications, and none of them were excluded due to insufficient image quality. Liver stiffness values ranged from 1.10 to 3.08 kPa. Whole-liver stiffness ranged from 1.56 to 2.75 kPa. Mean segmental stiffness differed significantly between the tested regions (range from 1.55 ± 0.28 to 2.37 ± 0.32 kPa; P < 0.0001, ANOVA)—Fig. 3, Table 1.Fig. 3

Bottom Line: Since the method is not well established, several different protocols were proposed that differ in results.Results of measurement within segment 8 were closest to the whole-liver method (ICC, 0.84).The most reproducible method is averaging of cross sections of the whole liver.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum, ul. Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland.

ABSTRACT

Purpose: MR elastography (MRE) is a recent non-invasive technique that provides in vivo data on the viscoelasticity of the liver. Since the method is not well established, several different protocols were proposed that differ in results. The aim of the study was to analyze the variability of stiffness measurements in different regions of the liver.

Methods: Twenty healthy adults aged 24-45 years were recruited. The examination was performed using a mechanical excitation of 64 Hz. MRE images were fused with axial T2WI breath-hold images (thickness 10 mm, spacing 10 mm). Stiffness was measured as a mean value of each cross section of the whole liver, on a single largest cross section, in the right lobe, and in ROIs (50 pix.) placed in the center of the left lobe, segments 5/6, 7, 8, and the parahilar region.

Results: Whole-liver stiffness ranged from 1.56 to 2.75 kPa. Mean segmental stiffness differed significantly between the tested regions (range from 1.55 ± 0.28 to 2.37 ± 0.32 kPa; P < 0.0001, ANOVA). Within-method variability of measurements ranged from 14 % for whole liver and segment 8-26 % for segment 7. Within-subject variability ranged from 13 to 31 %. Results of measurement within segment 8 were closest to the whole-liver method (ICC, 0.84).

Conclusions: Stiffness of the liver presented significant variability depending on the region of measurement. The most reproducible method is averaging of cross sections of the whole liver. There was significant variability between stiffness in subjects considered healthy, which requires further investigation.

Show MeSH
Related in: MedlinePlus