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Biologic-free remission of established rheumatoid arthritis after discontinuation of abatacept: a prospective, multicentre, observational study in Japan.

Takeuchi T, Matsubara T, Ohta S, Mukai M, Amano K, Tohma S, Tanaka Y, Yamanaka H, Miyasaka N - Rheumatology (Oxford) (2014)

Bottom Line: Clinical, functional and structural outcomes were compared between those who continued and those who discontinued abatacept.Those attaining DAS28-CRP < 2.3 or < 2.7 without abatacept at the endpoint had significantly lower HAQ-DI score and/or CRP at enrolment.Non-serious adverse events occurred in three patients who continued or resumed abatacept.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Department of Rheumatology, Matsubara Mayflower Hospital, Kato, Department of Rheumatology, Taga General Hospital, Hitachi, Division of Rheumatology and Clinical Immunology, Department of Medicine, Sapporo City General Hospital, Sapporo, Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Hospital, Kitakyushu, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo and Tokyo Medical and Dental University, Tokyo, Japan. tsutake@z5.keio.jp.

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Proportion of disease activity
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keu338-F2: Proportion of disease activity

Mentions: Fig. 2 shows the proportion of patients in each RA disease activity class at specified times. In the discontinuation group there was a tendency towards a decrease in the proportion of patients in DAS28-CRP remission and an increase in the proportion of those with HDA as follow-up progressed. At week 52 (LOCF), the proportion of patients in remission was 41.2% in the discontinuation group compared with 64.7% in the continuation group (P = 0.144). Sixteen of the 17 continuing patients (94.1%) experienced no disease flare (DAS28-CRP < 2.7), while 20 of the 34 discontinuing patients (58.8%) were in remission or maintained LDA. Compared with the 14 patients who failed to do so, these 20 patients had significantly lower baseline HAQ-DI scores and CRP (P = 0.036 and P = 0.048, respectively). Of the 19 patients who went without abatacept for 52 weeks, 7 were in remission at the endpoint and 12 were not. These two subgroups had comparable baseline characteristics, except that more patients in remission than not in remission at the endpoint were in functional remission (HAQ-DI ≤ 0.5) at enrolment (100% vs 41.7%, P = 0.016). The mean time-averaged DAS28-CRP (TA-DAS28-CRP) [19, 20] was 1.9 (s.d. 0.4) for those who maintained LDA compared with 3.0 (s.d. 0.7) for those who failed to do so (P < 0.0001).Fig. 2


Biologic-free remission of established rheumatoid arthritis after discontinuation of abatacept: a prospective, multicentre, observational study in Japan.

Takeuchi T, Matsubara T, Ohta S, Mukai M, Amano K, Tohma S, Tanaka Y, Yamanaka H, Miyasaka N - Rheumatology (Oxford) (2014)

Proportion of disease activity
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372674&req=5

keu338-F2: Proportion of disease activity
Mentions: Fig. 2 shows the proportion of patients in each RA disease activity class at specified times. In the discontinuation group there was a tendency towards a decrease in the proportion of patients in DAS28-CRP remission and an increase in the proportion of those with HDA as follow-up progressed. At week 52 (LOCF), the proportion of patients in remission was 41.2% in the discontinuation group compared with 64.7% in the continuation group (P = 0.144). Sixteen of the 17 continuing patients (94.1%) experienced no disease flare (DAS28-CRP < 2.7), while 20 of the 34 discontinuing patients (58.8%) were in remission or maintained LDA. Compared with the 14 patients who failed to do so, these 20 patients had significantly lower baseline HAQ-DI scores and CRP (P = 0.036 and P = 0.048, respectively). Of the 19 patients who went without abatacept for 52 weeks, 7 were in remission at the endpoint and 12 were not. These two subgroups had comparable baseline characteristics, except that more patients in remission than not in remission at the endpoint were in functional remission (HAQ-DI ≤ 0.5) at enrolment (100% vs 41.7%, P = 0.016). The mean time-averaged DAS28-CRP (TA-DAS28-CRP) [19, 20] was 1.9 (s.d. 0.4) for those who maintained LDA compared with 3.0 (s.d. 0.7) for those who failed to do so (P < 0.0001).Fig. 2

Bottom Line: Clinical, functional and structural outcomes were compared between those who continued and those who discontinued abatacept.Those attaining DAS28-CRP < 2.3 or < 2.7 without abatacept at the endpoint had significantly lower HAQ-DI score and/or CRP at enrolment.Non-serious adverse events occurred in three patients who continued or resumed abatacept.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Department of Rheumatology, Matsubara Mayflower Hospital, Kato, Department of Rheumatology, Taga General Hospital, Hitachi, Division of Rheumatology and Clinical Immunology, Department of Medicine, Sapporo City General Hospital, Sapporo, Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Hospital, Kitakyushu, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo and Tokyo Medical and Dental University, Tokyo, Japan. tsutake@z5.keio.jp.

Show MeSH
Related in: MedlinePlus