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The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease.

Alizade E, Avcı A, Açar G, Fidan S, Öcal L, Bulut M, Tellice M, Akçakoyun M, Pala S, Esen AM - Postepy Kardiol Interwencyjnej (2015)

Bottom Line: Patients with acute coronary syndrome and chronic immune disorders were excluded.Patients were divided into two groups.Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22.

View Article: PubMed Central - PubMed

Affiliation: Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey.

ABSTRACT

Introduction: The relation between serum rheumatoid factor levels and the extent, severity, and complexity of coronary artery disease has not been adequately studied.

Aim: Therefore, we assessed the relationship between the severity of coronary artery disease assessed by SYNTAX score and serum rheumatoid factor levels in patients with stable coronary artery disease.

Material and methods: We enrolled 268 consecutive patients who underwent coronary angiography. Patients with acute coronary syndrome and chronic immune disorders were excluded. Baseline serum rheumatoid factor levels were measured and the SYNTAX score was calculated from the study population.

Results: Patients were divided into two groups. Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22. Serum rheumatoid factor levels were significantly higher in the intermediate and high-SYNTAX score group than in the low-SYNTAX score group (16.4 ±9 IU/mlvs. 11.36 ±5 IU/ml, p < 0.001). Also, there was a significant correlation between rheumatoid factor and CRP levels with the SYNTAX score r = 0.411; p < 0.001 and r = 0.275; p < 0.001, respectively. On multivariate linear regression analysis, rheumatoid factor (β = 0.101, p < 0.001) was an independent risk factor for intermediate and high SYNTAX score in patients with stable coronary artery disease. In receiver operator characteristic curve analysis, optimal cut-off value of rheumatoid factor to predict high SYNTAX score was found to be 10.5 IU/ml, with 69% sensitivity and 61% specificity.

Conclusions: The rheumatoid factor level was independently associated with the extent, complexity, and severity of coronary artery disease assessed by SYNTAX score in patients with stable coronary artery diseases.

No MeSH data available.


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Receiver-operating characteristic curves of CRP for the identification of patients with intermediate to high SX score
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Figure 0003: Receiver-operating characteristic curves of CRP for the identification of patients with intermediate to high SX score

Mentions: The effects of multiple variables on the intermediate to high SX score were analysed with univariate and multivariate linear regression analyses. The parameters which had shown significance in the univariate analysis (age, male sex, RF, LDL, CrCl, DM, HT, family history of CAD, CRP, fasting blood glucose, and smoking) were evaluated by multivariate linear regression analysis in order to determine the independent predictors of intermediate to high SX score. Thus, serum RF, diabetes mellitus, hypertension, LDL-cholesterol, CRP, and smoking were found to be independent predictors of intermediate to high SX score (Table II). The ROC analysis yielded a cut-off value of 10.5 IU/ml for RF to predict intermediate to high SX score with 69% sensitivity and 61% specificity, with the area under the ROC curve being 0.727 (95% CI: 0.658–0.795, p < 0.001) (Figure 2). The ROC analysis yielded a cut off value of 0.432 mg/dl for CRP to predict high SX score with 67% sensitivity and 56% specificity, with the area under the ROC curve being 0.669 (95% CI: 0.595–0.744, p < 0.001) (Figure 3).


The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease.

Alizade E, Avcı A, Açar G, Fidan S, Öcal L, Bulut M, Tellice M, Akçakoyun M, Pala S, Esen AM - Postepy Kardiol Interwencyjnej (2015)

Receiver-operating characteristic curves of CRP for the identification of patients with intermediate to high SX score
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372628&req=5

Figure 0003: Receiver-operating characteristic curves of CRP for the identification of patients with intermediate to high SX score
Mentions: The effects of multiple variables on the intermediate to high SX score were analysed with univariate and multivariate linear regression analyses. The parameters which had shown significance in the univariate analysis (age, male sex, RF, LDL, CrCl, DM, HT, family history of CAD, CRP, fasting blood glucose, and smoking) were evaluated by multivariate linear regression analysis in order to determine the independent predictors of intermediate to high SX score. Thus, serum RF, diabetes mellitus, hypertension, LDL-cholesterol, CRP, and smoking were found to be independent predictors of intermediate to high SX score (Table II). The ROC analysis yielded a cut-off value of 10.5 IU/ml for RF to predict intermediate to high SX score with 69% sensitivity and 61% specificity, with the area under the ROC curve being 0.727 (95% CI: 0.658–0.795, p < 0.001) (Figure 2). The ROC analysis yielded a cut off value of 0.432 mg/dl for CRP to predict high SX score with 67% sensitivity and 56% specificity, with the area under the ROC curve being 0.669 (95% CI: 0.595–0.744, p < 0.001) (Figure 3).

Bottom Line: Patients with acute coronary syndrome and chronic immune disorders were excluded.Patients were divided into two groups.Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22.

View Article: PubMed Central - PubMed

Affiliation: Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey.

ABSTRACT

Introduction: The relation between serum rheumatoid factor levels and the extent, severity, and complexity of coronary artery disease has not been adequately studied.

Aim: Therefore, we assessed the relationship between the severity of coronary artery disease assessed by SYNTAX score and serum rheumatoid factor levels in patients with stable coronary artery disease.

Material and methods: We enrolled 268 consecutive patients who underwent coronary angiography. Patients with acute coronary syndrome and chronic immune disorders were excluded. Baseline serum rheumatoid factor levels were measured and the SYNTAX score was calculated from the study population.

Results: Patients were divided into two groups. Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22. Serum rheumatoid factor levels were significantly higher in the intermediate and high-SYNTAX score group than in the low-SYNTAX score group (16.4 ±9 IU/mlvs. 11.36 ±5 IU/ml, p < 0.001). Also, there was a significant correlation between rheumatoid factor and CRP levels with the SYNTAX score r = 0.411; p < 0.001 and r = 0.275; p < 0.001, respectively. On multivariate linear regression analysis, rheumatoid factor (β = 0.101, p < 0.001) was an independent risk factor for intermediate and high SYNTAX score in patients with stable coronary artery disease. In receiver operator characteristic curve analysis, optimal cut-off value of rheumatoid factor to predict high SYNTAX score was found to be 10.5 IU/ml, with 69% sensitivity and 61% specificity.

Conclusions: The rheumatoid factor level was independently associated with the extent, complexity, and severity of coronary artery disease assessed by SYNTAX score in patients with stable coronary artery diseases.

No MeSH data available.


Related in: MedlinePlus