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The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease.

Alizade E, Avcı A, Açar G, Fidan S, Öcal L, Bulut M, Tellice M, Akçakoyun M, Pala S, Esen AM - Postepy Kardiol Interwencyjnej (2015)

Bottom Line: Patients with acute coronary syndrome and chronic immune disorders were excluded.Patients were divided into two groups.Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22.

View Article: PubMed Central - PubMed

Affiliation: Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey.

ABSTRACT

Introduction: The relation between serum rheumatoid factor levels and the extent, severity, and complexity of coronary artery disease has not been adequately studied.

Aim: Therefore, we assessed the relationship between the severity of coronary artery disease assessed by SYNTAX score and serum rheumatoid factor levels in patients with stable coronary artery disease.

Material and methods: We enrolled 268 consecutive patients who underwent coronary angiography. Patients with acute coronary syndrome and chronic immune disorders were excluded. Baseline serum rheumatoid factor levels were measured and the SYNTAX score was calculated from the study population.

Results: Patients were divided into two groups. Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22. Serum rheumatoid factor levels were significantly higher in the intermediate and high-SYNTAX score group than in the low-SYNTAX score group (16.4 ±9 IU/mlvs. 11.36 ±5 IU/ml, p < 0.001). Also, there was a significant correlation between rheumatoid factor and CRP levels with the SYNTAX score r = 0.411; p < 0.001 and r = 0.275; p < 0.001, respectively. On multivariate linear regression analysis, rheumatoid factor (β = 0.101, p < 0.001) was an independent risk factor for intermediate and high SYNTAX score in patients with stable coronary artery disease. In receiver operator characteristic curve analysis, optimal cut-off value of rheumatoid factor to predict high SYNTAX score was found to be 10.5 IU/ml, with 69% sensitivity and 61% specificity.

Conclusions: The rheumatoid factor level was independently associated with the extent, complexity, and severity of coronary artery disease assessed by SYNTAX score in patients with stable coronary artery diseases.

No MeSH data available.


Related in: MedlinePlus

Correlation plot from rheumatoid factor levels and SX score
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Figure 0001: Correlation plot from rheumatoid factor levels and SX score

Mentions: The RF levels were significantly higher in the intermediate to high SX score group than in the low SX score group (16.4 ±9 IU/ml vs. 11.36 ±5 IU/ml, p < 0.001). A positive RF was present in 12 (7%) in the low SX score group and 38 (40%) in the intermediate to high SX score group. Also, there was a significant correlation between RF and CRP levels with the SX score (r = 0.411; p < 0.001; (Figure 1) and r = 0.275; p < 0.001, respectively). Moreover, RF and CRP levels were found to be well correlated with each other (r = 0.353; p < 0.001).


The relationship between rheumatoid factor levels and coronary artery lesion complexity and severity in patients with stable coronary artery disease.

Alizade E, Avcı A, Açar G, Fidan S, Öcal L, Bulut M, Tellice M, Akçakoyun M, Pala S, Esen AM - Postepy Kardiol Interwencyjnej (2015)

Correlation plot from rheumatoid factor levels and SX score
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372628&req=5

Figure 0001: Correlation plot from rheumatoid factor levels and SX score
Mentions: The RF levels were significantly higher in the intermediate to high SX score group than in the low SX score group (16.4 ±9 IU/ml vs. 11.36 ±5 IU/ml, p < 0.001). A positive RF was present in 12 (7%) in the low SX score group and 38 (40%) in the intermediate to high SX score group. Also, there was a significant correlation between RF and CRP levels with the SX score (r = 0.411; p < 0.001; (Figure 1) and r = 0.275; p < 0.001, respectively). Moreover, RF and CRP levels were found to be well correlated with each other (r = 0.353; p < 0.001).

Bottom Line: Patients with acute coronary syndrome and chronic immune disorders were excluded.Patients were divided into two groups.Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22.

View Article: PubMed Central - PubMed

Affiliation: Kartal Kosuyolu Heart Training and Research Hospital, Istanbul, Turkey.

ABSTRACT

Introduction: The relation between serum rheumatoid factor levels and the extent, severity, and complexity of coronary artery disease has not been adequately studied.

Aim: Therefore, we assessed the relationship between the severity of coronary artery disease assessed by SYNTAX score and serum rheumatoid factor levels in patients with stable coronary artery disease.

Material and methods: We enrolled 268 consecutive patients who underwent coronary angiography. Patients with acute coronary syndrome and chronic immune disorders were excluded. Baseline serum rheumatoid factor levels were measured and the SYNTAX score was calculated from the study population.

Results: Patients were divided into two groups. Group 1 was defined as low SYNTAX score < 22, and group 2 was defined as intermediate and high SYNTAX score > 22. Serum rheumatoid factor levels were significantly higher in the intermediate and high-SYNTAX score group than in the low-SYNTAX score group (16.4 ±9 IU/mlvs. 11.36 ±5 IU/ml, p < 0.001). Also, there was a significant correlation between rheumatoid factor and CRP levels with the SYNTAX score r = 0.411; p < 0.001 and r = 0.275; p < 0.001, respectively. On multivariate linear regression analysis, rheumatoid factor (β = 0.101, p < 0.001) was an independent risk factor for intermediate and high SYNTAX score in patients with stable coronary artery disease. In receiver operator characteristic curve analysis, optimal cut-off value of rheumatoid factor to predict high SYNTAX score was found to be 10.5 IU/ml, with 69% sensitivity and 61% specificity.

Conclusions: The rheumatoid factor level was independently associated with the extent, complexity, and severity of coronary artery disease assessed by SYNTAX score in patients with stable coronary artery diseases.

No MeSH data available.


Related in: MedlinePlus