Limits...
Expression of cell adhesion molecules in canine choroid plexus tumors.

Hirose N, Uchida K, Matsunaga S, Chambers JK, Nakayama H - J. Vet. Med. Sci. (2014)

Bottom Line: The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin.The other cases were positive for the three molecules examined.These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo 113-8657, Japan.

ABSTRACT
Choroid plexus tumor (CPT) is a primary intracranial neoplasm of the choroid plexus epithelium in the central nervous system. In the current World Health Organization classification, CPT is classified into two categories; choroid plexus papilloma (CPP) and carcinoma (CPC). In the present study, we investigated immunohistochemical expressions of N-cadherin, E-cadherin and β-catenin in 5 canine CPT cases (1 disseminated CPC, 2 CPCs and 2 CPPs). One CPP case was positive for N-cadherin and β-catenin, but negative for E-cadherin. The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin. The other cases were positive for the three molecules examined. These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

Show MeSH

Related in: MedlinePlus

Immunohistochemistry. Case no. 1. Expression of E-cadherin in the tumor cells. Bar: 100 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4372612&req=5

fig_005: Immunohistochemistry. Case no. 1. Expression of E-cadherin in the tumor cells. Bar: 100 µm.

Mentions: CP, choroid plexus; dCPC, disseminated CPC.


Expression of cell adhesion molecules in canine choroid plexus tumors.

Hirose N, Uchida K, Matsunaga S, Chambers JK, Nakayama H - J. Vet. Med. Sci. (2014)

Immunohistochemistry. Case no. 1. Expression of E-cadherin in the tumor cells. Bar: 100 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372612&req=5

fig_005: Immunohistochemistry. Case no. 1. Expression of E-cadherin in the tumor cells. Bar: 100 µm.
Mentions: CP, choroid plexus; dCPC, disseminated CPC.

Bottom Line: The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin.The other cases were positive for the three molecules examined.These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo 113-8657, Japan.

ABSTRACT
Choroid plexus tumor (CPT) is a primary intracranial neoplasm of the choroid plexus epithelium in the central nervous system. In the current World Health Organization classification, CPT is classified into two categories; choroid plexus papilloma (CPP) and carcinoma (CPC). In the present study, we investigated immunohistochemical expressions of N-cadherin, E-cadherin and β-catenin in 5 canine CPT cases (1 disseminated CPC, 2 CPCs and 2 CPPs). One CPP case was positive for N-cadherin and β-catenin, but negative for E-cadherin. The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin. The other cases were positive for the three molecules examined. These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

Show MeSH
Related in: MedlinePlus