Limits...
Expression of cell adhesion molecules in canine choroid plexus tumors.

Hirose N, Uchida K, Matsunaga S, Chambers JK, Nakayama H - J. Vet. Med. Sci. (2014)

Bottom Line: The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin.The other cases were positive for the three molecules examined.These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo 113-8657, Japan.

ABSTRACT
Choroid plexus tumor (CPT) is a primary intracranial neoplasm of the choroid plexus epithelium in the central nervous system. In the current World Health Organization classification, CPT is classified into two categories; choroid plexus papilloma (CPP) and carcinoma (CPC). In the present study, we investigated immunohistochemical expressions of N-cadherin, E-cadherin and β-catenin in 5 canine CPT cases (1 disseminated CPC, 2 CPCs and 2 CPPs). One CPP case was positive for N-cadherin and β-catenin, but negative for E-cadherin. The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin. The other cases were positive for the three molecules examined. These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

Show MeSH

Related in: MedlinePlus

Magnetic resonance images. Case no. 1. A: T2WI, B: T1WI and C: T1WI contrasted with gadolinium. Multiple neoplastic lesions between the right and left temporal lobes (arrows).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4372612&req=5

fig_001: Magnetic resonance images. Case no. 1. A: T2WI, B: T1WI and C: T1WI contrasted with gadolinium. Multiple neoplastic lesions between the right and left temporal lobes (arrows).

Mentions: Case histories of the dogs were as follows. Case no. 1 showed the stumbling in rear limbs and 5 months later the opisthotonus and incomplete paralysis in forelimbs. The postural reflex in the both right limbs was lost, the patellar reflex in the right rear limb was enhanced, the menace response in the right eye was lost, the direct pupillary light reflex in the both eyes was weakened, the indirect pupillary light reflex in the both eyes was lost, and cervical muscles in both sides were atrophied. The results of magnetic resonance image (MRI) examination of case no. 1 revealed multiple lesions measuring 2 to 13 mm in diameter in the right ventral thalamus, right temporal lobes, right and left occipital lobes and left pons (Fig. 1A–CFig. 1.


Expression of cell adhesion molecules in canine choroid plexus tumors.

Hirose N, Uchida K, Matsunaga S, Chambers JK, Nakayama H - J. Vet. Med. Sci. (2014)

Magnetic resonance images. Case no. 1. A: T2WI, B: T1WI and C: T1WI contrasted with gadolinium. Multiple neoplastic lesions between the right and left temporal lobes (arrows).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4372612&req=5

fig_001: Magnetic resonance images. Case no. 1. A: T2WI, B: T1WI and C: T1WI contrasted with gadolinium. Multiple neoplastic lesions between the right and left temporal lobes (arrows).
Mentions: Case histories of the dogs were as follows. Case no. 1 showed the stumbling in rear limbs and 5 months later the opisthotonus and incomplete paralysis in forelimbs. The postural reflex in the both right limbs was lost, the patellar reflex in the right rear limb was enhanced, the menace response in the right eye was lost, the direct pupillary light reflex in the both eyes was weakened, the indirect pupillary light reflex in the both eyes was lost, and cervical muscles in both sides were atrophied. The results of magnetic resonance image (MRI) examination of case no. 1 revealed multiple lesions measuring 2 to 13 mm in diameter in the right ventral thalamus, right temporal lobes, right and left occipital lobes and left pons (Fig. 1A–CFig. 1.

Bottom Line: The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin.The other cases were positive for the three molecules examined.These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo 113-8657, Japan.

ABSTRACT
Choroid plexus tumor (CPT) is a primary intracranial neoplasm of the choroid plexus epithelium in the central nervous system. In the current World Health Organization classification, CPT is classified into two categories; choroid plexus papilloma (CPP) and carcinoma (CPC). In the present study, we investigated immunohistochemical expressions of N-cadherin, E-cadherin and β-catenin in 5 canine CPT cases (1 disseminated CPC, 2 CPCs and 2 CPPs). One CPP case was positive for N-cadherin and β-catenin, but negative for E-cadherin. The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin. The other cases were positive for the three molecules examined. These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

Show MeSH
Related in: MedlinePlus