Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs.
Bottom Line: Increasing the number of sensitisation injections from 2 to 3 did not alter the responses.Increasing the Ova sensitisation concentration from 100 to 150 μg significantly increased total cells, particularly eosinophils.It has also demonstrated an important dissociation between EAR, LAR, AHR and inflammation.
Affiliation: Cardiff School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Ave, Cardiff CF10 3NB, United Kingdom.Show MeSH
Related in: MedlinePlus
Mentions: Fig. 1 represents the mean time-course changes in sGaw over 24 h following Ova challenge in conscious guinea-pigs sensitised and challenged with saline or protocols 1–6.
Affiliation: Cardiff School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Ave, Cardiff CF10 3NB, United Kingdom.