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Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia.

Barnes SA, Sawiak SJ, Caprioli D, Jupp B, Buonincontri G, Mar AC, Harte MK, Fletcher PC, Robbins TW, Neill JC, Dalley JW - Int. J. Neuropsychopharmacol. (2014)

Bottom Line: In contrast, sub-chronic PCP had no significant effect on the attentional filtering of a pre-pulse auditory stimulus in an acoustic startle paradigm.Voxel-based morphometry revealed significantly reduced grey matter density bilaterally in the hippocampus, anterior cingulate cortex, ventral striatum, and amygdala.Furthermore, PCP exposure resulted in dissociable impairments in attentional function.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA (Dr Barnes); Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Downing St, Cambridge UK (Drs Sawiak, Caprioli, Jupp, Mar, Fletcher, Robbins, and Dalley); Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (Drs Sawiak and Buonincontri); Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (Drs Fletcher and Dalley); Manchester Pharmacy School, University of Manchester, UK (Drs Harte and Neill).

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Average voxel-based cortical thickness in rats treated with PCP. Scale bar in mm (A). Areas of significantly reduced cortical thickness in PCP-treated animals compared with saline-treated animals; the scale bar shows student’s t-score based on 14 degrees of freedom. Results surviving a cluster-extent correction for family-wise error p < 0.05 are shown (B). Coronal sections indicating reduced cortical thickness in the insular cortex, left somatosensory cortex (S1; C; panel 1), granular and dysgranular insular cortex (panel 2), granular, dysgranular insular cortex, and ectorhinal cortex (panel 3). Regions identified using Paxinos and Watson (1997).
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Figure 4: Average voxel-based cortical thickness in rats treated with PCP. Scale bar in mm (A). Areas of significantly reduced cortical thickness in PCP-treated animals compared with saline-treated animals; the scale bar shows student’s t-score based on 14 degrees of freedom. Results surviving a cluster-extent correction for family-wise error p < 0.05 are shown (B). Coronal sections indicating reduced cortical thickness in the insular cortex, left somatosensory cortex (S1; C; panel 1), granular and dysgranular insular cortex (panel 2), granular, dysgranular insular cortex, and ectorhinal cortex (panel 3). Regions identified using Paxinos and Watson (1997).

Mentions: The mean cortical thickness of control and PCP rats is shown in Figure 4. Significant clusters demonstrating a reduction in cortical thickness in PCP rats were found in the lateral somatosensory cortex and insula cortex anteriorly and posteriorly bordering the ectorhinal cortex (Figure 4B and C). Qualitatively similar differences were observed bilaterally, though the significance scores were lower on the right side and did not survive correction for multiple comparisons.


Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia.

Barnes SA, Sawiak SJ, Caprioli D, Jupp B, Buonincontri G, Mar AC, Harte MK, Fletcher PC, Robbins TW, Neill JC, Dalley JW - Int. J. Neuropsychopharmacol. (2014)

Average voxel-based cortical thickness in rats treated with PCP. Scale bar in mm (A). Areas of significantly reduced cortical thickness in PCP-treated animals compared with saline-treated animals; the scale bar shows student’s t-score based on 14 degrees of freedom. Results surviving a cluster-extent correction for family-wise error p < 0.05 are shown (B). Coronal sections indicating reduced cortical thickness in the insular cortex, left somatosensory cortex (S1; C; panel 1), granular and dysgranular insular cortex (panel 2), granular, dysgranular insular cortex, and ectorhinal cortex (panel 3). Regions identified using Paxinos and Watson (1997).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4368881&req=5

Figure 4: Average voxel-based cortical thickness in rats treated with PCP. Scale bar in mm (A). Areas of significantly reduced cortical thickness in PCP-treated animals compared with saline-treated animals; the scale bar shows student’s t-score based on 14 degrees of freedom. Results surviving a cluster-extent correction for family-wise error p < 0.05 are shown (B). Coronal sections indicating reduced cortical thickness in the insular cortex, left somatosensory cortex (S1; C; panel 1), granular and dysgranular insular cortex (panel 2), granular, dysgranular insular cortex, and ectorhinal cortex (panel 3). Regions identified using Paxinos and Watson (1997).
Mentions: The mean cortical thickness of control and PCP rats is shown in Figure 4. Significant clusters demonstrating a reduction in cortical thickness in PCP rats were found in the lateral somatosensory cortex and insula cortex anteriorly and posteriorly bordering the ectorhinal cortex (Figure 4B and C). Qualitatively similar differences were observed bilaterally, though the significance scores were lower on the right side and did not survive correction for multiple comparisons.

Bottom Line: In contrast, sub-chronic PCP had no significant effect on the attentional filtering of a pre-pulse auditory stimulus in an acoustic startle paradigm.Voxel-based morphometry revealed significantly reduced grey matter density bilaterally in the hippocampus, anterior cingulate cortex, ventral striatum, and amygdala.Furthermore, PCP exposure resulted in dissociable impairments in attentional function.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA (Dr Barnes); Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Downing St, Cambridge UK (Drs Sawiak, Caprioli, Jupp, Mar, Fletcher, Robbins, and Dalley); Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (Drs Sawiak and Buonincontri); Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK (Drs Fletcher and Dalley); Manchester Pharmacy School, University of Manchester, UK (Drs Harte and Neill).

Show MeSH
Related in: MedlinePlus