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Erotic stimulus processing under amisulpride and reboxetine: a placebo-controlled fMRI study in healthy subjects.

Graf H, Wiegers M, Metzger CD, Walter M, Grön G, Abler B - Int. J. Neuropsychopharmacol. (2014)

Bottom Line: Impaired sexual function is increasingly recognized as a side effect of psychopharmacological treatment.Altered neural activations correlated with decreased sexual interest.In line with previous interpretations of the role of the caudate nucleus in the context of primary reward processing, attenuated caudate activation may reflect detrimental effects on motivational aspects of erotic stimulus processing under noradrenergic agents.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry III, Ulm University, Ulm, Germany (Drs Graf, Wiegers, Grön, and Abler); Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany (Drs Metzger and Walter); Leibniz Institute for Neurobiology, Magdeburg, Germany (Drs Metzger and Walter). heiko.graf@uni-ulm.de.

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Results of the multiple regression analysis of fMRI data and MGH-SFQ subscales as regressors within a mask comprising the voxels with a significant placebo-by-reboxetine interaction (actual cluster size: 565). A significant correlation (mean partial correlation coefficient r=0.709) was observed within the ventral part (head) of the right caudate nucleus for the subscale “sexual interest” under reboxetine relative to placebo. Statistical threshold was chosen at P<0.0025 with a critical cluster extent of 22 voxels to control for multiple testing within the reduced search volume. It is of note that the multiple regression was computed for exploratory purposes only to exploit the different information given by the 5 different subscales. Inference of the affected brain region had exclusively been based on the statistical comparisons on the categorical between-treatment differences.
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Figure 3: Results of the multiple regression analysis of fMRI data and MGH-SFQ subscales as regressors within a mask comprising the voxels with a significant placebo-by-reboxetine interaction (actual cluster size: 565). A significant correlation (mean partial correlation coefficient r=0.709) was observed within the ventral part (head) of the right caudate nucleus for the subscale “sexual interest” under reboxetine relative to placebo. Statistical threshold was chosen at P<0.0025 with a critical cluster extent of 22 voxels to control for multiple testing within the reduced search volume. It is of note that the multiple regression was computed for exploratory purposes only to exploit the different information given by the 5 different subscales. Inference of the affected brain region had exclusively been based on the statistical comparisons on the categorical between-treatment differences.

Mentions: A multiple regression analysis was computed to test for relations of subjectively experienced changes in sexual functioning and differential fMRI activations under the SNRI reboxetine against placebo. We revealed a significant partial correlation within the ventral part of the right caudate nucleus (mean partial correlation coefficient r= 0.709, P = 0.05 FWE corrected at cluster level; number of voxels: 22; peak Z-value: 3.10; x, y, z =10, 22, 4) with the MGH-SFQ subscale “sexual interest” indicating that decreased neural activation was accompanied by decreased sexual interest (Figure 3). None of the other MGH-SFQ subscales correlated significantly with fMRI activation differences.


Erotic stimulus processing under amisulpride and reboxetine: a placebo-controlled fMRI study in healthy subjects.

Graf H, Wiegers M, Metzger CD, Walter M, Grön G, Abler B - Int. J. Neuropsychopharmacol. (2014)

Results of the multiple regression analysis of fMRI data and MGH-SFQ subscales as regressors within a mask comprising the voxels with a significant placebo-by-reboxetine interaction (actual cluster size: 565). A significant correlation (mean partial correlation coefficient r=0.709) was observed within the ventral part (head) of the right caudate nucleus for the subscale “sexual interest” under reboxetine relative to placebo. Statistical threshold was chosen at P<0.0025 with a critical cluster extent of 22 voxels to control for multiple testing within the reduced search volume. It is of note that the multiple regression was computed for exploratory purposes only to exploit the different information given by the 5 different subscales. Inference of the affected brain region had exclusively been based on the statistical comparisons on the categorical between-treatment differences.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4368880&req=5

Figure 3: Results of the multiple regression analysis of fMRI data and MGH-SFQ subscales as regressors within a mask comprising the voxels with a significant placebo-by-reboxetine interaction (actual cluster size: 565). A significant correlation (mean partial correlation coefficient r=0.709) was observed within the ventral part (head) of the right caudate nucleus for the subscale “sexual interest” under reboxetine relative to placebo. Statistical threshold was chosen at P<0.0025 with a critical cluster extent of 22 voxels to control for multiple testing within the reduced search volume. It is of note that the multiple regression was computed for exploratory purposes only to exploit the different information given by the 5 different subscales. Inference of the affected brain region had exclusively been based on the statistical comparisons on the categorical between-treatment differences.
Mentions: A multiple regression analysis was computed to test for relations of subjectively experienced changes in sexual functioning and differential fMRI activations under the SNRI reboxetine against placebo. We revealed a significant partial correlation within the ventral part of the right caudate nucleus (mean partial correlation coefficient r= 0.709, P = 0.05 FWE corrected at cluster level; number of voxels: 22; peak Z-value: 3.10; x, y, z =10, 22, 4) with the MGH-SFQ subscale “sexual interest” indicating that decreased neural activation was accompanied by decreased sexual interest (Figure 3). None of the other MGH-SFQ subscales correlated significantly with fMRI activation differences.

Bottom Line: Impaired sexual function is increasingly recognized as a side effect of psychopharmacological treatment.Altered neural activations correlated with decreased sexual interest.In line with previous interpretations of the role of the caudate nucleus in the context of primary reward processing, attenuated caudate activation may reflect detrimental effects on motivational aspects of erotic stimulus processing under noradrenergic agents.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry III, Ulm University, Ulm, Germany (Drs Graf, Wiegers, Grön, and Abler); Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany (Drs Metzger and Walter); Leibniz Institute for Neurobiology, Magdeburg, Germany (Drs Metzger and Walter). heiko.graf@uni-ulm.de.

Show MeSH
Related in: MedlinePlus