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The association between metabolic syndrome or chronic kidney disease and hearing thresholds in Koreans: the Korean National Health and Nutrition Examination Survey 2009-2012.

Kang SH, Jung da J, Cho KH, Park JW, Yoon KW, Do JY - PLoS ONE (2015)

Bottom Line: The hearing thresholds for men were significantly higher than the hearing thresholds for women in all 3 threshold categories.Male and female subjects with MetS or CKD had higher hearing thresholds than the subjects that did not have these disorders.MetS is associated with hearing thresholds in women, and CKD is associated with hearing thresholds in men and women.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Republic of Korea.

ABSTRACT

Background: The aim of this study was to determine whether metabolic syndrome (MetS) or chronic kidney disease (CKD) is associated with hearing thresholds in the general Korean population.

Patients and methods: A total of 16,554 participants were included in this study. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III guidelines, and CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 or a dipstick proteinuria result of ≥1+. The hearing thresholds were measured at 0.5, 1, 2, 3, 4, and 6 kHz. Low-frequency (Freq) was defined as pure-tone averages at 0.5 and 1 kHz, while Mid-Freq and High-Freq were defined as the average thresholds at mid-frequency (2 and 3 kHz) and high frequency (4 and 6 kHz), respectively.

Results: In men, the hearing thresholds were 15.1 ± 14.5 dB, 22.2 ± 21.3 dB, and 37.3 ± 26.5 dB for Low-, Mid-, and High-Freq, respectively. In women, the hearing thresholds were 14.9 ± 15.3 dB, 16.6 ± 18.0 dB, and 26.1 ± 21.5 dB for Low-, Mid-, and High-Freq, respectively. The hearing thresholds for men were significantly higher than the hearing thresholds for women in all 3 threshold categories. Male and female subjects with MetS or CKD had higher hearing thresholds than the subjects that did not have these disorders. In the multivariate analysis, MetS was associated with increased hearing thresholds in women, and CKD was associated with increased hearing thresholds in men and women.

Conclusion: MetS is associated with hearing thresholds in women, and CKD is associated with hearing thresholds in men and women. Therefore, patients with MetS or CKD should be closely monitored for hearing impairment.

No MeSH data available.


Related in: MedlinePlus

Influence on hearing threshold according to the presence of metabolic syndrome (MetS) and/or chronic kidney disease (CKD).A. Men B. Women (*P < 0.05 compared to subjects with neither MetS nor CKD, #P < 0.05 compared to subjects with neither MetS nor CKD, and to subjects with only MetS). Abbreviations: CKD, chronic kidney disease; MetS, metabolic syndrome; PTA, pure tone audiometry; Low-Freq, low-frequency; Mid-Freq, mid-frequency; High-Freq, high-frequency; dB, decibel.
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pone.0120372.g003: Influence on hearing threshold according to the presence of metabolic syndrome (MetS) and/or chronic kidney disease (CKD).A. Men B. Women (*P < 0.05 compared to subjects with neither MetS nor CKD, #P < 0.05 compared to subjects with neither MetS nor CKD, and to subjects with only MetS). Abbreviations: CKD, chronic kidney disease; MetS, metabolic syndrome; PTA, pure tone audiometry; Low-Freq, low-frequency; Mid-Freq, mid-frequency; High-Freq, high-frequency; dB, decibel.

Mentions: The hearing thresholds were significantly higher in men with CKD than those in men without CKD (Low-Freq: 26.4 ± 19.1 dB vs. 14.5 ± 14.0 dB; Mid-Freq: 41.3 ± 24.3 dB vs. 21.2 ± 20.6 dB; High-Freq: 60.4 ± 25.0 dB vs. 36.1 ± 26.0 dB, respectively; P < 0.001) (Fig. 2A). Similarly, the hearing thresholds were significantly higher in women with CKD than those in women without CKD (Low-Freq: 27.4 ± 20.0 dB vs. 14.4 ± 14.9 dB; Mid-Freq: 33.5 ± 22.4 dB vs. 16 ± 17.6 dB; High-Freq: 47.4 ± 23.8 dB vs. 25.3 ± 21.0 dB, respectively; P < 0.001) (Fig. 2B). Among the male subjects, 4,661 subjects had neither MetS nor CKD, 1,743 had only MetS, 169 had only CKD, and 161 had both MetS and CKD. Among the female subjects, 6,967 subjects had neither MetS nor CKD, 2,508 had only MetS, 119 had only CKD, and 206 had both MetS and CKD. However, 7 men and 13 women were excluded due to a lack of data. Men and women with only MetS had higher hearing thresholds than the subjects with neither MetS nor CKD (Fig. 3A-B). Subjects with only CKD had higher hearing thresholds than those with neither MetS nor CKD. However, there were no significant differences in the hearing thresholds of subjects with only CKD and those with both MetS and CKD. These findings indicate that MetS does not have an additive effect among subjects with CKD.


The association between metabolic syndrome or chronic kidney disease and hearing thresholds in Koreans: the Korean National Health and Nutrition Examination Survey 2009-2012.

Kang SH, Jung da J, Cho KH, Park JW, Yoon KW, Do JY - PLoS ONE (2015)

Influence on hearing threshold according to the presence of metabolic syndrome (MetS) and/or chronic kidney disease (CKD).A. Men B. Women (*P < 0.05 compared to subjects with neither MetS nor CKD, #P < 0.05 compared to subjects with neither MetS nor CKD, and to subjects with only MetS). Abbreviations: CKD, chronic kidney disease; MetS, metabolic syndrome; PTA, pure tone audiometry; Low-Freq, low-frequency; Mid-Freq, mid-frequency; High-Freq, high-frequency; dB, decibel.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4368756&req=5

pone.0120372.g003: Influence on hearing threshold according to the presence of metabolic syndrome (MetS) and/or chronic kidney disease (CKD).A. Men B. Women (*P < 0.05 compared to subjects with neither MetS nor CKD, #P < 0.05 compared to subjects with neither MetS nor CKD, and to subjects with only MetS). Abbreviations: CKD, chronic kidney disease; MetS, metabolic syndrome; PTA, pure tone audiometry; Low-Freq, low-frequency; Mid-Freq, mid-frequency; High-Freq, high-frequency; dB, decibel.
Mentions: The hearing thresholds were significantly higher in men with CKD than those in men without CKD (Low-Freq: 26.4 ± 19.1 dB vs. 14.5 ± 14.0 dB; Mid-Freq: 41.3 ± 24.3 dB vs. 21.2 ± 20.6 dB; High-Freq: 60.4 ± 25.0 dB vs. 36.1 ± 26.0 dB, respectively; P < 0.001) (Fig. 2A). Similarly, the hearing thresholds were significantly higher in women with CKD than those in women without CKD (Low-Freq: 27.4 ± 20.0 dB vs. 14.4 ± 14.9 dB; Mid-Freq: 33.5 ± 22.4 dB vs. 16 ± 17.6 dB; High-Freq: 47.4 ± 23.8 dB vs. 25.3 ± 21.0 dB, respectively; P < 0.001) (Fig. 2B). Among the male subjects, 4,661 subjects had neither MetS nor CKD, 1,743 had only MetS, 169 had only CKD, and 161 had both MetS and CKD. Among the female subjects, 6,967 subjects had neither MetS nor CKD, 2,508 had only MetS, 119 had only CKD, and 206 had both MetS and CKD. However, 7 men and 13 women were excluded due to a lack of data. Men and women with only MetS had higher hearing thresholds than the subjects with neither MetS nor CKD (Fig. 3A-B). Subjects with only CKD had higher hearing thresholds than those with neither MetS nor CKD. However, there were no significant differences in the hearing thresholds of subjects with only CKD and those with both MetS and CKD. These findings indicate that MetS does not have an additive effect among subjects with CKD.

Bottom Line: The hearing thresholds for men were significantly higher than the hearing thresholds for women in all 3 threshold categories.Male and female subjects with MetS or CKD had higher hearing thresholds than the subjects that did not have these disorders.MetS is associated with hearing thresholds in women, and CKD is associated with hearing thresholds in men and women.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Republic of Korea.

ABSTRACT

Background: The aim of this study was to determine whether metabolic syndrome (MetS) or chronic kidney disease (CKD) is associated with hearing thresholds in the general Korean population.

Patients and methods: A total of 16,554 participants were included in this study. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III guidelines, and CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 or a dipstick proteinuria result of ≥1+. The hearing thresholds were measured at 0.5, 1, 2, 3, 4, and 6 kHz. Low-frequency (Freq) was defined as pure-tone averages at 0.5 and 1 kHz, while Mid-Freq and High-Freq were defined as the average thresholds at mid-frequency (2 and 3 kHz) and high frequency (4 and 6 kHz), respectively.

Results: In men, the hearing thresholds were 15.1 ± 14.5 dB, 22.2 ± 21.3 dB, and 37.3 ± 26.5 dB for Low-, Mid-, and High-Freq, respectively. In women, the hearing thresholds were 14.9 ± 15.3 dB, 16.6 ± 18.0 dB, and 26.1 ± 21.5 dB for Low-, Mid-, and High-Freq, respectively. The hearing thresholds for men were significantly higher than the hearing thresholds for women in all 3 threshold categories. Male and female subjects with MetS or CKD had higher hearing thresholds than the subjects that did not have these disorders. In the multivariate analysis, MetS was associated with increased hearing thresholds in women, and CKD was associated with increased hearing thresholds in men and women.

Conclusion: MetS is associated with hearing thresholds in women, and CKD is associated with hearing thresholds in men and women. Therefore, patients with MetS or CKD should be closely monitored for hearing impairment.

No MeSH data available.


Related in: MedlinePlus