Limits...
Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications.

González-Sánchez MI, Perni S, Tommasi G, Morris NG, Hawkins K, López-Cabarcos E, Prokopovich P - Mater Sci Eng C Mater Biol Appl (2015)

Bottom Line: In the present paper, we describe the integration of silver nanoparticles in the polymeric mineralized biomaterial to provide non-antibiotic antibacterial activity against Staphylococcus epidermidis and Methicillin-resistant Staphylococcus aureus.Two different crosslinking degrees were tested and the silver nanoparticles were integrated into the composite matrix by means of three different methods: entrapment in the polymeric hydrogel before the mineralization; diffusion during the process of calcium phosphate crystallization and adsorption post-mineralization.The latter being generally the most effective method of encapsulation; however, the adsorption of silver nanoparticles inside the pores of the biomaterial led to a decreasing antibacterial activity for adsorption time longer than 2 days.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Chemistry, School of Industrial Engineering, Castilla-La Mancha University, Albacete, Spain; Department of Physical Chemistry II, Complutense University of Madrid, Madrid, Spain; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.

Show MeSH

Related in: MedlinePlus

(a) Storage (G′) and (b) loss modulus (G″) of hydrogels with 7% (filled symbols) and 2.5% (empty symbols) of crosslinker after immersion in a solution silver nanoparticles (1 mM).● after 1 day, ▼ after 2 days.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4368440&req=5

f0040: (a) Storage (G′) and (b) loss modulus (G″) of hydrogels with 7% (filled symbols) and 2.5% (empty symbols) of crosslinker after immersion in a solution silver nanoparticles (1 mM).● after 1 day, ▼ after 2 days.


Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications.

González-Sánchez MI, Perni S, Tommasi G, Morris NG, Hawkins K, López-Cabarcos E, Prokopovich P - Mater Sci Eng C Mater Biol Appl (2015)

(a) Storage (G′) and (b) loss modulus (G″) of hydrogels with 7% (filled symbols) and 2.5% (empty symbols) of crosslinker after immersion in a solution silver nanoparticles (1 mM).● after 1 day, ▼ after 2 days.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4368440&req=5

f0040: (a) Storage (G′) and (b) loss modulus (G″) of hydrogels with 7% (filled symbols) and 2.5% (empty symbols) of crosslinker after immersion in a solution silver nanoparticles (1 mM).● after 1 day, ▼ after 2 days.
Bottom Line: In the present paper, we describe the integration of silver nanoparticles in the polymeric mineralized biomaterial to provide non-antibiotic antibacterial activity against Staphylococcus epidermidis and Methicillin-resistant Staphylococcus aureus.Two different crosslinking degrees were tested and the silver nanoparticles were integrated into the composite matrix by means of three different methods: entrapment in the polymeric hydrogel before the mineralization; diffusion during the process of calcium phosphate crystallization and adsorption post-mineralization.The latter being generally the most effective method of encapsulation; however, the adsorption of silver nanoparticles inside the pores of the biomaterial led to a decreasing antibacterial activity for adsorption time longer than 2 days.

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Chemistry, School of Industrial Engineering, Castilla-La Mancha University, Albacete, Spain; Department of Physical Chemistry II, Complutense University of Madrid, Madrid, Spain; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.

Show MeSH
Related in: MedlinePlus