Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications.
Bottom Line: In the present paper, we describe the integration of silver nanoparticles in the polymeric mineralized biomaterial to provide non-antibiotic antibacterial activity against Staphylococcus epidermidis and Methicillin-resistant Staphylococcus aureus.Two different crosslinking degrees were tested and the silver nanoparticles were integrated into the composite matrix by means of three different methods: entrapment in the polymeric hydrogel before the mineralization; diffusion during the process of calcium phosphate crystallization and adsorption post-mineralization.The latter being generally the most effective method of encapsulation; however, the adsorption of silver nanoparticles inside the pores of the biomaterial led to a decreasing antibacterial activity for adsorption time longer than 2 days.
Affiliation: Department of Physical Chemistry, School of Industrial Engineering, Castilla-La Mancha University, Albacete, Spain; Department of Physical Chemistry II, Complutense University of Madrid, Madrid, Spain; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.Show MeSH
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Mentions: It is possible that the citrate ions present in the silvernanoparticle solution interfere with the polymerization reaction acting as radicalscavenger as citrate ions are known antioxidant . This activity would increase the level ofun-reacted monomers and thus reduce the length of the polymer chains. Suchphenomenon would explain the lower mechanical properties of the hydrogels whennanoparticles are present, instead of their enhancement as in a normalnanocomposite material. No particular impact on both G’ and G” was noticed whensilver nanoparticles were embedded through adsorption post hydrogelsmineralization (Fig. 8, Fig. 9) independently from the length of the adsorption.
Affiliation: Department of Physical Chemistry, School of Industrial Engineering, Castilla-La Mancha University, Albacete, Spain; Department of Physical Chemistry II, Complutense University of Madrid, Madrid, Spain; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.