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Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs.

Escobar C, Pateira S, Lobo E, Lobo L, Teodosio R, Dias F, Fernandes N, Arez AP, Varandas L, Nogueira F - PLoS ONE (2015)

Bottom Line: The R471R mutation detected in Angola has already been reported in Africa (DR-Congo and Gabon).However, the mutations R575R (Angola) and V494I (Mozambique), have never been reported.V494I is adjacent to the known K13 resistance-associated mutation Y493H, although functional analysis did not predict a deleterious effect on protein function.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Pediatria, Hospital Prof. Doutor Fernando Fonseca EPE, Amadora, Portugal; Unidade de Ensino e Investigação de Clínica Tropical (UEICT), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.

ABSTRACT
We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem. Samples were collected before and after ACT introduction as first-line treatment. In each country 50 samples collected before and 50 after ACT introduction were analysed. A total of three different mutations (R471R and R575R in Angola and V494I in Mozambique) were identified in five samples, all collected after the introduction of ACT. The R471R mutation detected in Angola has already been reported in Africa (DR-Congo and Gabon). However, the mutations R575R (Angola) and V494I (Mozambique), have never been reported. V494I is adjacent to the known K13 resistance-associated mutation Y493H, although functional analysis did not predict a deleterious effect on protein function.

No MeSH data available.


Related in: MedlinePlus

P. falciparum K13-propeller polymorphisms prevalence and distribution in Angola and Mozambique.Panel 1) Proportion within each time period of wild type (wt) and mutant (mut) samples; Panel 2) Geographical location of sample collection (dark grey) and identified polymorphisms.
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pone.0119215.g001: P. falciparum K13-propeller polymorphisms prevalence and distribution in Angola and Mozambique.Panel 1) Proportion within each time period of wild type (wt) and mutant (mut) samples; Panel 2) Geographical location of sample collection (dark grey) and identified polymorphisms.

Mentions: A total of 3 different mutations (R471R, V494I, R575R) were found in 5 samples (2.5%). All mutations were found in samples collected after the introduction of ACTs as the official first-line treatment in each country. Fig. 1 shows geographical origin of the samples and time period, and Table 1 shows K13-propeller polymorphisms identified.


Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs.

Escobar C, Pateira S, Lobo E, Lobo L, Teodosio R, Dias F, Fernandes N, Arez AP, Varandas L, Nogueira F - PLoS ONE (2015)

P. falciparum K13-propeller polymorphisms prevalence and distribution in Angola and Mozambique.Panel 1) Proportion within each time period of wild type (wt) and mutant (mut) samples; Panel 2) Geographical location of sample collection (dark grey) and identified polymorphisms.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366227&req=5

pone.0119215.g001: P. falciparum K13-propeller polymorphisms prevalence and distribution in Angola and Mozambique.Panel 1) Proportion within each time period of wild type (wt) and mutant (mut) samples; Panel 2) Geographical location of sample collection (dark grey) and identified polymorphisms.
Mentions: A total of 3 different mutations (R471R, V494I, R575R) were found in 5 samples (2.5%). All mutations were found in samples collected after the introduction of ACTs as the official first-line treatment in each country. Fig. 1 shows geographical origin of the samples and time period, and Table 1 shows K13-propeller polymorphisms identified.

Bottom Line: The R471R mutation detected in Angola has already been reported in Africa (DR-Congo and Gabon).However, the mutations R575R (Angola) and V494I (Mozambique), have never been reported.V494I is adjacent to the known K13 resistance-associated mutation Y493H, although functional analysis did not predict a deleterious effect on protein function.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Pediatria, Hospital Prof. Doutor Fernando Fonseca EPE, Amadora, Portugal; Unidade de Ensino e Investigação de Clínica Tropical (UEICT), Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal.

ABSTRACT
We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem. Samples were collected before and after ACT introduction as first-line treatment. In each country 50 samples collected before and 50 after ACT introduction were analysed. A total of three different mutations (R471R and R575R in Angola and V494I in Mozambique) were identified in five samples, all collected after the introduction of ACT. The R471R mutation detected in Angola has already been reported in Africa (DR-Congo and Gabon). However, the mutations R575R (Angola) and V494I (Mozambique), have never been reported. V494I is adjacent to the known K13 resistance-associated mutation Y493H, although functional analysis did not predict a deleterious effect on protein function.

No MeSH data available.


Related in: MedlinePlus