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Detailed contact data and the dissemination of Staphylococcus aureus in hospitals.

Obadia T, Silhol R, Opatowski L, Temime L, Legrand J, Thiébaut AC, Herrmann JL, Fleury É, Guillemot D, Boëlle PY, I-Bird Study Gro - PLoS Comput. Biol. (2015)

Bottom Line: In the broad diversity of isolated S. aureus strains, 173 transmission events were observed between participants.Additional analyses revealed a higher dissemination risk between patients via healthcare workers than via other patients.In conclusion, S. aureus transmission was consistent with contacts defined by electronically collected CPIs, illustrating their potential as a tool to control hospital-acquired infections and help direct surveillance.

View Article: PubMed Central - PubMed

Affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France; INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France.

ABSTRACT
Close proximity interactions (CPIs) measured by wireless electronic devices are increasingly used in epidemiological models. However, no evidence supports that electronically collected CPIs inform on the contacts leading to transmission. Here, we analyzed Staphylococcus aureus carriage and CPIs recorded simultaneously in a long-term care facility for 4 months in 329 patients and 261 healthcare workers to test this hypothesis. In the broad diversity of isolated S. aureus strains, 173 transmission events were observed between participants. The joint analysis of carriage and CPIs showed that CPI paths linking incident cases to other individuals carrying the same strain (i.e. possible infectors) had fewer intermediaries than predicted by chance (P < 0.001), a feature that simulations showed to be the signature of transmission along CPIs. Additional analyses revealed a higher dissemination risk between patients via healthcare workers than via other patients. In conclusion, S. aureus transmission was consistent with contacts defined by electronically collected CPIs, illustrating their potential as a tool to control hospital-acquired infections and help direct surveillance.

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Related in: MedlinePlus

Mean daily numbers and durations of patients’ and HCWs’ CPIs.Bars illustrate CPIs with patients (black) and HCWs (white).
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pcbi.1004170.g002: Mean daily numbers and durations of patients’ and HCWs’ CPIs.Bars illustrate CPIs with patients (black) and HCWs (white).

Mentions: CPIs were recorded among 590 individuals (329 patients and 261 HCWs) during the 4-month period (Table 1), and yielded 85,025 daily CPIs. Each day, a CPI network was defined with study participants as nodes and CPIs as edges (Fig. 1). The collection of daily CPI networks defined the “dynamic CPI network”. While the numbers of CPIs were within the same range for patients and HCWs, the daily-cumulative durations of the CPIs were much longer for patients than HCWs, respectively: 12.2 (± 11.3) h (mean ± SD) vs. 3.7 (± 2.4) h (Fig. 2). Further description of the dynamic CPI network is provided in S2 Text.


Detailed contact data and the dissemination of Staphylococcus aureus in hospitals.

Obadia T, Silhol R, Opatowski L, Temime L, Legrand J, Thiébaut AC, Herrmann JL, Fleury É, Guillemot D, Boëlle PY, I-Bird Study Gro - PLoS Comput. Biol. (2015)

Mean daily numbers and durations of patients’ and HCWs’ CPIs.Bars illustrate CPIs with patients (black) and HCWs (white).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366219&req=5

pcbi.1004170.g002: Mean daily numbers and durations of patients’ and HCWs’ CPIs.Bars illustrate CPIs with patients (black) and HCWs (white).
Mentions: CPIs were recorded among 590 individuals (329 patients and 261 HCWs) during the 4-month period (Table 1), and yielded 85,025 daily CPIs. Each day, a CPI network was defined with study participants as nodes and CPIs as edges (Fig. 1). The collection of daily CPI networks defined the “dynamic CPI network”. While the numbers of CPIs were within the same range for patients and HCWs, the daily-cumulative durations of the CPIs were much longer for patients than HCWs, respectively: 12.2 (± 11.3) h (mean ± SD) vs. 3.7 (± 2.4) h (Fig. 2). Further description of the dynamic CPI network is provided in S2 Text.

Bottom Line: In the broad diversity of isolated S. aureus strains, 173 transmission events were observed between participants.Additional analyses revealed a higher dissemination risk between patients via healthcare workers than via other patients.In conclusion, S. aureus transmission was consistent with contacts defined by electronically collected CPIs, illustrating their potential as a tool to control hospital-acquired infections and help direct surveillance.

View Article: PubMed Central - PubMed

Affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France; INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, F-75013, Paris, France.

ABSTRACT
Close proximity interactions (CPIs) measured by wireless electronic devices are increasingly used in epidemiological models. However, no evidence supports that electronically collected CPIs inform on the contacts leading to transmission. Here, we analyzed Staphylococcus aureus carriage and CPIs recorded simultaneously in a long-term care facility for 4 months in 329 patients and 261 healthcare workers to test this hypothesis. In the broad diversity of isolated S. aureus strains, 173 transmission events were observed between participants. The joint analysis of carriage and CPIs showed that CPI paths linking incident cases to other individuals carrying the same strain (i.e. possible infectors) had fewer intermediaries than predicted by chance (P < 0.001), a feature that simulations showed to be the signature of transmission along CPIs. Additional analyses revealed a higher dissemination risk between patients via healthcare workers than via other patients. In conclusion, S. aureus transmission was consistent with contacts defined by electronically collected CPIs, illustrating their potential as a tool to control hospital-acquired infections and help direct surveillance.

Show MeSH
Related in: MedlinePlus