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Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets.

Tareen SH, Ahmad J - PLoS ONE (2015)

Bottom Line: Recent studies have found that the circadian rhythms of several peripheral organs in mammals, such as the liver, are able to entrain their clocks to received signals independent of other system level clocks, in particular when responding to signals generated during feeding.These studies have found SIRT1, PARP1, and HSF1 proteins to be the major influencers of the core CLOCKBMAL1:PER-CRY circadian clock.The modelled feeding regimens suggest that the usual 3 meals/day and 2 meals/day feeding regimens are beneficial with any more or less meals/day negatively affecting the system.

View Article: PubMed Central - PubMed

Affiliation: Department of Computational Sciences, Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Islamabad, Pakistan.

ABSTRACT
Circadian rhythms are certain periodic behaviours exhibited by living organism at different levels, including cellular and system-wide scales. Recent studies have found that the circadian rhythms of several peripheral organs in mammals, such as the liver, are able to entrain their clocks to received signals independent of other system level clocks, in particular when responding to signals generated during feeding. These studies have found SIRT1, PARP1, and HSF1 proteins to be the major influencers of the core CLOCKBMAL1:PER-CRY circadian clock. These entities, along with abstracted feeding induced signals were modelled collectively in this study using Petri Nets. The properties of the model show that the circadian system itself is strongly robust, and is able to continually evolve. The modelled feeding regimens suggest that the usual 3 meals/day and 2 meals/day feeding regimens are beneficial with any more or less meals/day negatively affecting the system.

No MeSH data available.


Simulation results depicting the over feeding scenario with 5 meals/day.The meals were simulated on 0800 hrs, 1100 hrs, 1400 hrs, 1700 hrs, and 2000 hrs, along with the 12 hour overnight fast. The results indicate an over expression of PARP1, with suppressed expressions of almost all entities, other than HSF1.
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pone.0117519.g011: Simulation results depicting the over feeding scenario with 5 meals/day.The meals were simulated on 0800 hrs, 1100 hrs, 1400 hrs, 1700 hrs, and 2000 hrs, along with the 12 hour overnight fast. The results indicate an over expression of PARP1, with suppressed expressions of almost all entities, other than HSF1.

Mentions: Scenario 3: Modelling 5 meals/day entrainment. This scenario is the complete opposite of Scenario 2, and thus models the case of over feeding via the 5 meals/day regimen based on the timings 0800 hrs, 1100 hrs, 1400 hrs, 1700 hrs, and 2000 hrs, with a 12 hour overnight fast. The simulation results, shown in Fig. 11, indicate that over feeding suppresses the expression of the core circadian clock, and just about diminishes any expression of SIRT1.


Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets.

Tareen SH, Ahmad J - PLoS ONE (2015)

Simulation results depicting the over feeding scenario with 5 meals/day.The meals were simulated on 0800 hrs, 1100 hrs, 1400 hrs, 1700 hrs, and 2000 hrs, along with the 12 hour overnight fast. The results indicate an over expression of PARP1, with suppressed expressions of almost all entities, other than HSF1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366204&req=5

pone.0117519.g011: Simulation results depicting the over feeding scenario with 5 meals/day.The meals were simulated on 0800 hrs, 1100 hrs, 1400 hrs, 1700 hrs, and 2000 hrs, along with the 12 hour overnight fast. The results indicate an over expression of PARP1, with suppressed expressions of almost all entities, other than HSF1.
Mentions: Scenario 3: Modelling 5 meals/day entrainment. This scenario is the complete opposite of Scenario 2, and thus models the case of over feeding via the 5 meals/day regimen based on the timings 0800 hrs, 1100 hrs, 1400 hrs, 1700 hrs, and 2000 hrs, with a 12 hour overnight fast. The simulation results, shown in Fig. 11, indicate that over feeding suppresses the expression of the core circadian clock, and just about diminishes any expression of SIRT1.

Bottom Line: Recent studies have found that the circadian rhythms of several peripheral organs in mammals, such as the liver, are able to entrain their clocks to received signals independent of other system level clocks, in particular when responding to signals generated during feeding.These studies have found SIRT1, PARP1, and HSF1 proteins to be the major influencers of the core CLOCKBMAL1:PER-CRY circadian clock.The modelled feeding regimens suggest that the usual 3 meals/day and 2 meals/day feeding regimens are beneficial with any more or less meals/day negatively affecting the system.

View Article: PubMed Central - PubMed

Affiliation: Department of Computational Sciences, Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Islamabad, Pakistan.

ABSTRACT
Circadian rhythms are certain periodic behaviours exhibited by living organism at different levels, including cellular and system-wide scales. Recent studies have found that the circadian rhythms of several peripheral organs in mammals, such as the liver, are able to entrain their clocks to received signals independent of other system level clocks, in particular when responding to signals generated during feeding. These studies have found SIRT1, PARP1, and HSF1 proteins to be the major influencers of the core CLOCKBMAL1:PER-CRY circadian clock. These entities, along with abstracted feeding induced signals were modelled collectively in this study using Petri Nets. The properties of the model show that the circadian system itself is strongly robust, and is able to continually evolve. The modelled feeding regimens suggest that the usual 3 meals/day and 2 meals/day feeding regimens are beneficial with any more or less meals/day negatively affecting the system.

No MeSH data available.