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The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.

Zhang Y, Zhao PW, Feng G, Xie G, Wang AQ, Yang YH, Wang D, Du XB - PLoS ONE (2015)

Bottom Line: The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively.Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively).Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, MianYang Central Hospital, MianYang, People's Republic of China; Department of Surgery, LuZhou Medical College, LuZhou, People's Republic of China.

ABSTRACT
The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis. The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively. Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively). Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.

No MeSH data available.


Related in: MedlinePlus

Kaplan—Meier curves of disease-free survival of the Y-box binding protein-1 expression status for patients with rectal cancer.
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pone.0119385.g004: Kaplan—Meier curves of disease-free survival of the Y-box binding protein-1 expression status for patients with rectal cancer.

Mentions: Higher YB-1 expression (HSCORE ≥ 200) was associated with poor disease-free survival (DFS) and overall survival (OS) (Figs. 4–5). The mean DFS was 38.2 months in 50/72 patients with rectal cancer, which was shorter than that of patients with lower YB-1 expression (HSCORE < 200). The mean DFS of patients with lower YB-1 expression was 52.4 months (P = 0.013). An analysis of OS revealed similar results. The mean OS time of patients with higher YB-1 expression (HSCORE ≥ 200) was 44.4 months, versus 57.3 months (P = 0.008) for patients with lower YB-1 expression (YB-1 HSCORE < 200).


The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.

Zhang Y, Zhao PW, Feng G, Xie G, Wang AQ, Yang YH, Wang D, Du XB - PLoS ONE (2015)

Kaplan—Meier curves of disease-free survival of the Y-box binding protein-1 expression status for patients with rectal cancer.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366156&req=5

pone.0119385.g004: Kaplan—Meier curves of disease-free survival of the Y-box binding protein-1 expression status for patients with rectal cancer.
Mentions: Higher YB-1 expression (HSCORE ≥ 200) was associated with poor disease-free survival (DFS) and overall survival (OS) (Figs. 4–5). The mean DFS was 38.2 months in 50/72 patients with rectal cancer, which was shorter than that of patients with lower YB-1 expression (HSCORE < 200). The mean DFS of patients with lower YB-1 expression was 52.4 months (P = 0.013). An analysis of OS revealed similar results. The mean OS time of patients with higher YB-1 expression (HSCORE ≥ 200) was 44.4 months, versus 57.3 months (P = 0.008) for patients with lower YB-1 expression (YB-1 HSCORE < 200).

Bottom Line: The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively.Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively).Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, MianYang Central Hospital, MianYang, People's Republic of China; Department of Surgery, LuZhou Medical College, LuZhou, People's Republic of China.

ABSTRACT
The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis. The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively. Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively). Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.

No MeSH data available.


Related in: MedlinePlus