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The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.

Zhang Y, Zhao PW, Feng G, Xie G, Wang AQ, Yang YH, Wang D, Du XB - PLoS ONE (2015)

Bottom Line: The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively.Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively).Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, MianYang Central Hospital, MianYang, People's Republic of China; Department of Surgery, LuZhou Medical College, LuZhou, People's Republic of China.

ABSTRACT
The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis. The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively. Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively). Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.

No MeSH data available.


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Immunohistochemical detection of Y-box binding protein-1 expression in rectal cancer tissue (200×).
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pone.0119385.g003: Immunohistochemical detection of Y-box binding protein-1 expression in rectal cancer tissue (200×).

Mentions: Rectal cancer cells exhibited diffuse YB-1 staining in the cytoplasm (Figs. 1–3). In non-cancerous rectal tissue, only weak YB-1 staining was observed. Nuclear staining was rarely observed in any of the tissue samples. The mean YB-1 HSCOREs for rectal cancer, tubular adenoma, and rectitis tissue samples were 205.5, 164.3, and 137.7, respectively. YB-1 expression levels were higher in tissue from patients with rectal cancer than in non-neoplastic rectal tissue (P = 0.000; Table 1). However, YB-1 expression did not display any obvious correlation with patient age (P = 0.153), sex (P = 0.657), cancer stage (P = 0.245), or adjuvant chemoradiotherapy (P = 0.761). The clinical features of these patients are shown in Table 2.


The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.

Zhang Y, Zhao PW, Feng G, Xie G, Wang AQ, Yang YH, Wang D, Du XB - PLoS ONE (2015)

Immunohistochemical detection of Y-box binding protein-1 expression in rectal cancer tissue (200×).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366156&req=5

pone.0119385.g003: Immunohistochemical detection of Y-box binding protein-1 expression in rectal cancer tissue (200×).
Mentions: Rectal cancer cells exhibited diffuse YB-1 staining in the cytoplasm (Figs. 1–3). In non-cancerous rectal tissue, only weak YB-1 staining was observed. Nuclear staining was rarely observed in any of the tissue samples. The mean YB-1 HSCOREs for rectal cancer, tubular adenoma, and rectitis tissue samples were 205.5, 164.3, and 137.7, respectively. YB-1 expression levels were higher in tissue from patients with rectal cancer than in non-neoplastic rectal tissue (P = 0.000; Table 1). However, YB-1 expression did not display any obvious correlation with patient age (P = 0.153), sex (P = 0.657), cancer stage (P = 0.245), or adjuvant chemoradiotherapy (P = 0.761). The clinical features of these patients are shown in Table 2.

Bottom Line: The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively.Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively).Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, MianYang Central Hospital, MianYang, People's Republic of China; Department of Surgery, LuZhou Medical College, LuZhou, People's Republic of China.

ABSTRACT
The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis. The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively. Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively). Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.

No MeSH data available.


Related in: MedlinePlus