Limits...
A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in China.

Tan Y, Fu J, Li X, Yang J, Jiang M, Ding K, Xu J, Li J, Yuan Y - PLoS ONE (2015)

Bottom Line: A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied.Patients with a component of signet-ring cells, regardless of the extent, had poor prognoses.Therefore, in clinical practice, patients with a component of signet-ring cells, regardless of the extent, should be given significant clinical attention.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Medical Oncology, 2nd Hospital of Zhejiang University School of Medicine, Hangzhou, P.R. China.

ABSTRACT

Background: We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass.

Methods: A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied. The patients were divided into five groups according to type of cancer: signet-ring cell carcinoma (with > 50% signet-ring cell, n = 36), partial signet-ring cell carcinoma (with < 50% signet-ring cell, n = 28), mucinous adenocarcinoma (with > 50% mucin lacking signet-ring cell, n = 267), partial mucinous adenocarcinoma (with < 50% mucin lacking signet-ring cell, n = 145), and classic adenocarcinoma (with absence of either mucin or signet-ring cell, n = 1978).

Results: Patients with > 50% or < 50% signet-ring cell had the lowest 5-year survival rates (35.5% and 29.7%, respectively), followed by patients with > 50% mucin (48.8%). Patients who had partial mucinous adenocarcinoma with < 50% mucin and classic adenocarcinoma patients had the highest 5-year survival rates (64.8% and 65.3%, respectively). Stratified and multivariate analysis showed that signet-ring cell carcinoma, partial signet-ring cell carcinoma and mucinous adenocarcinoma were independent predictors of decreased survival (hazard ratio 1.699, P = 0.016; hazard ratio 2.182, P = 0.005; hazard ratio 1.532, P < 0.001; respectively), and partial mucinous adenocarcinoma was not (hazard ratio 1.137, P = 0.431).

Conclusions: Patients with a component of signet-ring cells, regardless of the extent, had poor prognoses. Patients with mucinous adenocarcinoma containing >50% mucin had poor prognoses as well, whereas those with < 50% mucin had survival rates similar to those of classic adenocarcinoma patients. Therefore, in clinical practice, patients with a component of signet-ring cells, regardless of the extent, should be given significant clinical attention.

No MeSH data available.


Related in: MedlinePlus

The overall survival of patients in the five groups.SRCC, signet-ring cell carcinoma; PSRCC, partial signet-ring cell carcinoma; MAC, mucinous adenocarcinoma; PMAC, partial mucinous adenocarcinoma; AC, classic adenocarcinoma.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4366148&req=5

pone.0121944.g002: The overall survival of patients in the five groups.SRCC, signet-ring cell carcinoma; PSRCC, partial signet-ring cell carcinoma; MAC, mucinous adenocarcinoma; PMAC, partial mucinous adenocarcinoma; AC, classic adenocarcinoma.

Mentions: The follow-up period lasted 1–302 months (median 32.7 months). The 5-year CSS and 10-year CSS of the overall population were 62.6% and 55.6%, respectively, as shown in Table 2. The Kaplan-Meier survival curves for these five groups are shown in Fig. 2. The 5-year CSS of SRCC and PSRCC patients were 35.5% and 29.7%, respectively, which were the worst prognoses among the five groups. Next were the MAC patients, with a 5-year CSS of 48.8%. The CSS of SRCC, PSRCC and MAC were all significantly lower than that of AC, and the P values were all <0.001. However, the difference in 5-year CSS between PMAC and AC was not significant (P = 0.621). A similar situation was observed for 10-year CSS.


A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in China.

Tan Y, Fu J, Li X, Yang J, Jiang M, Ding K, Xu J, Li J, Yuan Y - PLoS ONE (2015)

The overall survival of patients in the five groups.SRCC, signet-ring cell carcinoma; PSRCC, partial signet-ring cell carcinoma; MAC, mucinous adenocarcinoma; PMAC, partial mucinous adenocarcinoma; AC, classic adenocarcinoma.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366148&req=5

pone.0121944.g002: The overall survival of patients in the five groups.SRCC, signet-ring cell carcinoma; PSRCC, partial signet-ring cell carcinoma; MAC, mucinous adenocarcinoma; PMAC, partial mucinous adenocarcinoma; AC, classic adenocarcinoma.
Mentions: The follow-up period lasted 1–302 months (median 32.7 months). The 5-year CSS and 10-year CSS of the overall population were 62.6% and 55.6%, respectively, as shown in Table 2. The Kaplan-Meier survival curves for these five groups are shown in Fig. 2. The 5-year CSS of SRCC and PSRCC patients were 35.5% and 29.7%, respectively, which were the worst prognoses among the five groups. Next were the MAC patients, with a 5-year CSS of 48.8%. The CSS of SRCC, PSRCC and MAC were all significantly lower than that of AC, and the P values were all <0.001. However, the difference in 5-year CSS between PMAC and AC was not significant (P = 0.621). A similar situation was observed for 10-year CSS.

Bottom Line: A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied.Patients with a component of signet-ring cells, regardless of the extent, had poor prognoses.Therefore, in clinical practice, patients with a component of signet-ring cells, regardless of the extent, should be given significant clinical attention.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Medical Oncology, 2nd Hospital of Zhejiang University School of Medicine, Hangzhou, P.R. China.

ABSTRACT

Background: We performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass.

Methods: A total of 2454 patients seen in our hospital from 1985 to 2011 were retrospectively studied. The patients were divided into five groups according to type of cancer: signet-ring cell carcinoma (with > 50% signet-ring cell, n = 36), partial signet-ring cell carcinoma (with < 50% signet-ring cell, n = 28), mucinous adenocarcinoma (with > 50% mucin lacking signet-ring cell, n = 267), partial mucinous adenocarcinoma (with < 50% mucin lacking signet-ring cell, n = 145), and classic adenocarcinoma (with absence of either mucin or signet-ring cell, n = 1978).

Results: Patients with > 50% or < 50% signet-ring cell had the lowest 5-year survival rates (35.5% and 29.7%, respectively), followed by patients with > 50% mucin (48.8%). Patients who had partial mucinous adenocarcinoma with < 50% mucin and classic adenocarcinoma patients had the highest 5-year survival rates (64.8% and 65.3%, respectively). Stratified and multivariate analysis showed that signet-ring cell carcinoma, partial signet-ring cell carcinoma and mucinous adenocarcinoma were independent predictors of decreased survival (hazard ratio 1.699, P = 0.016; hazard ratio 2.182, P = 0.005; hazard ratio 1.532, P < 0.001; respectively), and partial mucinous adenocarcinoma was not (hazard ratio 1.137, P = 0.431).

Conclusions: Patients with a component of signet-ring cells, regardless of the extent, had poor prognoses. Patients with mucinous adenocarcinoma containing >50% mucin had poor prognoses as well, whereas those with < 50% mucin had survival rates similar to those of classic adenocarcinoma patients. Therefore, in clinical practice, patients with a component of signet-ring cells, regardless of the extent, should be given significant clinical attention.

No MeSH data available.


Related in: MedlinePlus