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Evaluation of shear wave velocity and human bone morphogenetic protein-7 for the diagnosis of diabetic kidney disease.

Yu N, Zhang YY, Niu XY, Xu Y, Ma RX, Zhang W, Jiang XB - PLoS ONE (2015)

Bottom Line: Correlations between groups as well as SWV and BMP-7 were analyzed.Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05).In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

ABSTRACT

Purpose: The aim of this study was to determine the diagnostic values of kidney shear wave velocity (SWV) and bone morphogenetic protein-7 (BMP-7), and their correlation in the diagnosis of early diabetic kidney disease.

Methods: A total of 150 patients with type 2 diabetes mellitus were divided into three equal groups based on the urinary albumin-creatinine ratio (ACR): normal albuminuria (normo- group, ACR < 30 mg/g creatinine, n = 50), microalbuminuria (micro- group, 30 ≤ ACR < 300 mg/g creatinine, n = 50), and macroalbuminuria (macro- group, ACR ≥ 300 mg/g creatinine and estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2, n = 50). Fifty healthy volunteers were recruited to serve as controls (control group). The levels of serum BMP-7 were detected, and virtual touch tissue quantification was used to detect the renal SWV value in all study subjects. Correlations between groups as well as SWV and BMP-7 were analyzed.

Results: Serum BMP-7 and SWV were significantly and progressively decreased and increased, respectively, during the development of renal disease, from the normo- to the micro- and to the macro- groups (all P < 0.01 between each other for BMP-7 and SWV). Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05). In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

Conclusion: The determination of SWV together with serum BMP-7 may play an important role in the diagnosis of diabetic kidney disease.

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Related in: MedlinePlus

Correlation between SWV and BMP-7 in DKD subjects.SWV, shear wave velocity; BMP-7, bone morphogenetic protein-7; r = -0.569; P < 0.05; linear regression equation: y = -38.127x + 159.641.
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pone.0119713.g003: Correlation between SWV and BMP-7 in DKD subjects.SWV, shear wave velocity; BMP-7, bone morphogenetic protein-7; r = -0.569; P < 0.05; linear regression equation: y = -38.127x + 159.641.

Mentions: The SWV values of all subjects were acquired successfully, and representative figure are depicted in Fig. 2 and summarized in Table 2. The mean SWV value of the macro- group was significantly greater than that of the micro- group, and that of the micro- group was significantly greater than that of the normo- group (P < 0.01). However, there was no significant difference between the normo- and the control groups (see Table 2 and Figs. 1 and 2). Next, we analyzed the correlation between the SWV and BMP-7 level; a significant and negative relationship was evident, with a correlation coefficient of-0.569 (P < 0.05, Fig. 3).


Evaluation of shear wave velocity and human bone morphogenetic protein-7 for the diagnosis of diabetic kidney disease.

Yu N, Zhang YY, Niu XY, Xu Y, Ma RX, Zhang W, Jiang XB - PLoS ONE (2015)

Correlation between SWV and BMP-7 in DKD subjects.SWV, shear wave velocity; BMP-7, bone morphogenetic protein-7; r = -0.569; P < 0.05; linear regression equation: y = -38.127x + 159.641.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366104&req=5

pone.0119713.g003: Correlation between SWV and BMP-7 in DKD subjects.SWV, shear wave velocity; BMP-7, bone morphogenetic protein-7; r = -0.569; P < 0.05; linear regression equation: y = -38.127x + 159.641.
Mentions: The SWV values of all subjects were acquired successfully, and representative figure are depicted in Fig. 2 and summarized in Table 2. The mean SWV value of the macro- group was significantly greater than that of the micro- group, and that of the micro- group was significantly greater than that of the normo- group (P < 0.01). However, there was no significant difference between the normo- and the control groups (see Table 2 and Figs. 1 and 2). Next, we analyzed the correlation between the SWV and BMP-7 level; a significant and negative relationship was evident, with a correlation coefficient of-0.569 (P < 0.05, Fig. 3).

Bottom Line: Correlations between groups as well as SWV and BMP-7 were analyzed.Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05).In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

ABSTRACT

Purpose: The aim of this study was to determine the diagnostic values of kidney shear wave velocity (SWV) and bone morphogenetic protein-7 (BMP-7), and their correlation in the diagnosis of early diabetic kidney disease.

Methods: A total of 150 patients with type 2 diabetes mellitus were divided into three equal groups based on the urinary albumin-creatinine ratio (ACR): normal albuminuria (normo- group, ACR < 30 mg/g creatinine, n = 50), microalbuminuria (micro- group, 30 ≤ ACR < 300 mg/g creatinine, n = 50), and macroalbuminuria (macro- group, ACR ≥ 300 mg/g creatinine and estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2, n = 50). Fifty healthy volunteers were recruited to serve as controls (control group). The levels of serum BMP-7 were detected, and virtual touch tissue quantification was used to detect the renal SWV value in all study subjects. Correlations between groups as well as SWV and BMP-7 were analyzed.

Results: Serum BMP-7 and SWV were significantly and progressively decreased and increased, respectively, during the development of renal disease, from the normo- to the micro- and to the macro- groups (all P < 0.01 between each other for BMP-7 and SWV). Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05). In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

Conclusion: The determination of SWV together with serum BMP-7 may play an important role in the diagnosis of diabetic kidney disease.

Show MeSH
Related in: MedlinePlus