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Evaluation of shear wave velocity and human bone morphogenetic protein-7 for the diagnosis of diabetic kidney disease.

Yu N, Zhang YY, Niu XY, Xu Y, Ma RX, Zhang W, Jiang XB - PLoS ONE (2015)

Bottom Line: Correlations between groups as well as SWV and BMP-7 were analyzed.Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05).In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

ABSTRACT

Purpose: The aim of this study was to determine the diagnostic values of kidney shear wave velocity (SWV) and bone morphogenetic protein-7 (BMP-7), and their correlation in the diagnosis of early diabetic kidney disease.

Methods: A total of 150 patients with type 2 diabetes mellitus were divided into three equal groups based on the urinary albumin-creatinine ratio (ACR): normal albuminuria (normo- group, ACR < 30 mg/g creatinine, n = 50), microalbuminuria (micro- group, 30 ≤ ACR < 300 mg/g creatinine, n = 50), and macroalbuminuria (macro- group, ACR ≥ 300 mg/g creatinine and estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2, n = 50). Fifty healthy volunteers were recruited to serve as controls (control group). The levels of serum BMP-7 were detected, and virtual touch tissue quantification was used to detect the renal SWV value in all study subjects. Correlations between groups as well as SWV and BMP-7 were analyzed.

Results: Serum BMP-7 and SWV were significantly and progressively decreased and increased, respectively, during the development of renal disease, from the normo- to the micro- and to the macro- groups (all P < 0.01 between each other for BMP-7 and SWV). Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05). In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

Conclusion: The determination of SWV together with serum BMP-7 may play an important role in the diagnosis of diabetic kidney disease.

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Related in: MedlinePlus

Shear wave velocity measurements.A Siemens ACUSON S2000 US system (Siemens, Germany) equipped with a 3.5–5.5 MHz linear array transducer (4C1) was used for the measurements. After measuring the cortex and medulla thicknesses in the lower pole of the kidney (the perpendicular distance from the apex of the pyramid to the capsule of the kidney), an acoustic push pulse was transmitted immediately in the region of interest (box with fixed dimensions of 1 cm × 0.5 cm). Three valid measurements were obtained for each kidney at the same portion of the mid-pole, as parallel as possible to the radically arranged tubular system. The results are expressed as meters per second (m/sec).
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pone.0119713.g002: Shear wave velocity measurements.A Siemens ACUSON S2000 US system (Siemens, Germany) equipped with a 3.5–5.5 MHz linear array transducer (4C1) was used for the measurements. After measuring the cortex and medulla thicknesses in the lower pole of the kidney (the perpendicular distance from the apex of the pyramid to the capsule of the kidney), an acoustic push pulse was transmitted immediately in the region of interest (box with fixed dimensions of 1 cm × 0.5 cm). Three valid measurements were obtained for each kidney at the same portion of the mid-pole, as parallel as possible to the radically arranged tubular system. The results are expressed as meters per second (m/sec).

Mentions: The SWV values of all subjects were acquired successfully, and representative figure are depicted in Fig. 2 and summarized in Table 2. The mean SWV value of the macro- group was significantly greater than that of the micro- group, and that of the micro- group was significantly greater than that of the normo- group (P < 0.01). However, there was no significant difference between the normo- and the control groups (see Table 2 and Figs. 1 and 2). Next, we analyzed the correlation between the SWV and BMP-7 level; a significant and negative relationship was evident, with a correlation coefficient of-0.569 (P < 0.05, Fig. 3).


Evaluation of shear wave velocity and human bone morphogenetic protein-7 for the diagnosis of diabetic kidney disease.

Yu N, Zhang YY, Niu XY, Xu Y, Ma RX, Zhang W, Jiang XB - PLoS ONE (2015)

Shear wave velocity measurements.A Siemens ACUSON S2000 US system (Siemens, Germany) equipped with a 3.5–5.5 MHz linear array transducer (4C1) was used for the measurements. After measuring the cortex and medulla thicknesses in the lower pole of the kidney (the perpendicular distance from the apex of the pyramid to the capsule of the kidney), an acoustic push pulse was transmitted immediately in the region of interest (box with fixed dimensions of 1 cm × 0.5 cm). Three valid measurements were obtained for each kidney at the same portion of the mid-pole, as parallel as possible to the radically arranged tubular system. The results are expressed as meters per second (m/sec).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366104&req=5

pone.0119713.g002: Shear wave velocity measurements.A Siemens ACUSON S2000 US system (Siemens, Germany) equipped with a 3.5–5.5 MHz linear array transducer (4C1) was used for the measurements. After measuring the cortex and medulla thicknesses in the lower pole of the kidney (the perpendicular distance from the apex of the pyramid to the capsule of the kidney), an acoustic push pulse was transmitted immediately in the region of interest (box with fixed dimensions of 1 cm × 0.5 cm). Three valid measurements were obtained for each kidney at the same portion of the mid-pole, as parallel as possible to the radically arranged tubular system. The results are expressed as meters per second (m/sec).
Mentions: The SWV values of all subjects were acquired successfully, and representative figure are depicted in Fig. 2 and summarized in Table 2. The mean SWV value of the macro- group was significantly greater than that of the micro- group, and that of the micro- group was significantly greater than that of the normo- group (P < 0.01). However, there was no significant difference between the normo- and the control groups (see Table 2 and Figs. 1 and 2). Next, we analyzed the correlation between the SWV and BMP-7 level; a significant and negative relationship was evident, with a correlation coefficient of-0.569 (P < 0.05, Fig. 3).

Bottom Line: Correlations between groups as well as SWV and BMP-7 were analyzed.Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05).In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

ABSTRACT

Purpose: The aim of this study was to determine the diagnostic values of kidney shear wave velocity (SWV) and bone morphogenetic protein-7 (BMP-7), and their correlation in the diagnosis of early diabetic kidney disease.

Methods: A total of 150 patients with type 2 diabetes mellitus were divided into three equal groups based on the urinary albumin-creatinine ratio (ACR): normal albuminuria (normo- group, ACR < 30 mg/g creatinine, n = 50), microalbuminuria (micro- group, 30 ≤ ACR < 300 mg/g creatinine, n = 50), and macroalbuminuria (macro- group, ACR ≥ 300 mg/g creatinine and estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2, n = 50). Fifty healthy volunteers were recruited to serve as controls (control group). The levels of serum BMP-7 were detected, and virtual touch tissue quantification was used to detect the renal SWV value in all study subjects. Correlations between groups as well as SWV and BMP-7 were analyzed.

Results: Serum BMP-7 and SWV were significantly and progressively decreased and increased, respectively, during the development of renal disease, from the normo- to the micro- and to the macro- groups (all P < 0.01 between each other for BMP-7 and SWV). Moreover, no significant differences between the normo- and control groups were observed for either BMP-7 or SWV (both P > 0.05). In addition, a significant correlation was found between SWV and BMP-7, with a coefficient of -0.569 (P < 0.05).

Conclusion: The determination of SWV together with serum BMP-7 may play an important role in the diagnosis of diabetic kidney disease.

Show MeSH
Related in: MedlinePlus