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Optimization of imaging parameters for SPECT scans of [99mTc]TRODAT-1 using Taguchi analysis.

Huang CK, Wu J, Cheng KY, Pan LK - PLoS ONE (2015)

Bottom Line: Strong cross interactions existed between the injection activity/uptake duration and injection activity/time per projection.Therefore, under the consideration of as low as reasonably achievable (ALARA) for radiation protection, we can decrease the injection activity to 740 MBq.The image quality remains almost the same for clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.

ABSTRACT
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the basal ganglia. Single photon emission computed tomography (SPECT) scans using [99mTc]TRODAT-1 can image dopamine transporters and provide valuable diagnostic information of PD. In this study, we optimized the scanning parameters for [99mTc]TRODAT-1/SPECT using the Taguchi analysis to improve image quality. SPECT scans were performed on forty-five healthy volunteers according to an L9 orthogonal array. Three parameters were considered, including the injection activity, uptake duration, and acquisition time per projection. The signal-to-noise ratio (SNR) was calculated from the striatum/occipital activity ratio as an image quality index. Ten healthy subjects and fifteen PD patients were used to verify the optimal parameters. The estimated optimal parameters were 962 MBq for [99mTc]TRODAT-1 injection, 260 min for uptake duration, and 60 s/projection for data acquisition. The uptake duration and time per projection were the two dominant factors which had an F-value of 18.638 (38%) and 25.933 (53%), respectively. Strong cross interactions existed between the injection activity/uptake duration and injection activity/time per projection. Therefore, under the consideration of as low as reasonably achievable (ALARA) for radiation protection, we can decrease the injection activity to 740 MBq. The image quality remains almost the same for clinical applications.

No MeSH data available.


Related in: MedlinePlus

Isopreference curves through the level space for (A) uptake duration and time per projection, (B) injection activity and time per projection, and (C) injection activity and uptake duration.The number on the curve indicates the percentage of image quality.
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pone.0113817.g005: Isopreference curves through the level space for (A) uptake duration and time per projection, (B) injection activity and time per projection, and (C) injection activity and uptake duration.The number on the curve indicates the percentage of image quality.

Mentions: By fixing one of the parameters, isopreference curves through the level space defined by the other two parameters are drawn in Fig. 5. Points lying on the curve correspond to the levels achieving the same image quality. The isopreference curves shifted upper right to level 3. With this flexibility, the scanning protocol can be adjusted based on the patient condition, such as the ability to remain still for a longer acquisition time or the reduction of radiation doses by injecting less radioactivity and adjusting the other two variables.


Optimization of imaging parameters for SPECT scans of [99mTc]TRODAT-1 using Taguchi analysis.

Huang CK, Wu J, Cheng KY, Pan LK - PLoS ONE (2015)

Isopreference curves through the level space for (A) uptake duration and time per projection, (B) injection activity and time per projection, and (C) injection activity and uptake duration.The number on the curve indicates the percentage of image quality.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4366084&req=5

pone.0113817.g005: Isopreference curves through the level space for (A) uptake duration and time per projection, (B) injection activity and time per projection, and (C) injection activity and uptake duration.The number on the curve indicates the percentage of image quality.
Mentions: By fixing one of the parameters, isopreference curves through the level space defined by the other two parameters are drawn in Fig. 5. Points lying on the curve correspond to the levels achieving the same image quality. The isopreference curves shifted upper right to level 3. With this flexibility, the scanning protocol can be adjusted based on the patient condition, such as the ability to remain still for a longer acquisition time or the reduction of radiation doses by injecting less radioactivity and adjusting the other two variables.

Bottom Line: Strong cross interactions existed between the injection activity/uptake duration and injection activity/time per projection.Therefore, under the consideration of as low as reasonably achievable (ALARA) for radiation protection, we can decrease the injection activity to 740 MBq.The image quality remains almost the same for clinical applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.

ABSTRACT
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the basal ganglia. Single photon emission computed tomography (SPECT) scans using [99mTc]TRODAT-1 can image dopamine transporters and provide valuable diagnostic information of PD. In this study, we optimized the scanning parameters for [99mTc]TRODAT-1/SPECT using the Taguchi analysis to improve image quality. SPECT scans were performed on forty-five healthy volunteers according to an L9 orthogonal array. Three parameters were considered, including the injection activity, uptake duration, and acquisition time per projection. The signal-to-noise ratio (SNR) was calculated from the striatum/occipital activity ratio as an image quality index. Ten healthy subjects and fifteen PD patients were used to verify the optimal parameters. The estimated optimal parameters were 962 MBq for [99mTc]TRODAT-1 injection, 260 min for uptake duration, and 60 s/projection for data acquisition. The uptake duration and time per projection were the two dominant factors which had an F-value of 18.638 (38%) and 25.933 (53%), respectively. Strong cross interactions existed between the injection activity/uptake duration and injection activity/time per projection. Therefore, under the consideration of as low as reasonably achievable (ALARA) for radiation protection, we can decrease the injection activity to 740 MBq. The image quality remains almost the same for clinical applications.

No MeSH data available.


Related in: MedlinePlus