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Elevation of IGF-2 receptor and the possible underlying implications in end-stage heart failure patients before and after heart transplantation.

Wei Y, Li J, Huang J, Zhang X, Zhao H, Cui C, Li Y, Hu S - J. Cell. Mol. Med. (2012)

Bottom Line: Cardiac IGF-2R levels increased in end-stage HF patients (n = 11) compared with non-failing control subjects.Leu27-IGF-2, an IGF-2 analogue to activate specially the IGF-2R, could induce apoptosis and reactive oxygen species production in neonatal rat ventricular myocytes.The serum IGF-2R levels were significantly higher in HF patients than those in non-failing control subjects.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. weiyingjiefw@126.com

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Histopathological analysis of IGF-2R. (A) Representative light microscopic findings in haematoxylin and eosin staining. The normal appearance of myocardial fibres with central nuclei is seen in non-failing control hearts (NF) and interstitial fibrosis replacement is found in DCM failing hearts (DCM-HF). (B) Representative light microscopic IGF-2R immunoreactivity using a monoclonal antibody, which recognizes IGF-2R. Few and weak immunoreactivity of IGF-2R is observed in non-failing control hearts (NF), but more and strong IGF-2R immunoreactivity can be seen in DCM failing hearts (DCM-HF). Arrows indicated the positive staining.
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fig02: Histopathological analysis of IGF-2R. (A) Representative light microscopic findings in haematoxylin and eosin staining. The normal appearance of myocardial fibres with central nuclei is seen in non-failing control hearts (NF) and interstitial fibrosis replacement is found in DCM failing hearts (DCM-HF). (B) Representative light microscopic IGF-2R immunoreactivity using a monoclonal antibody, which recognizes IGF-2R. Few and weak immunoreactivity of IGF-2R is observed in non-failing control hearts (NF), but more and strong IGF-2R immunoreactivity can be seen in DCM failing hearts (DCM-HF). Arrows indicated the positive staining.

Mentions: Interstitial fibrosis in DCM-HF was observed compared with NF in the HE staining (Fig. 2A). In the immunohistochemical staining, the control specimens from NF exhibited few and weak IGF-2R immunoreactivity. In contrast, more and strong IGF-2R immunoreactivity was observed in DCM-HF (Fig. 2B).


Elevation of IGF-2 receptor and the possible underlying implications in end-stage heart failure patients before and after heart transplantation.

Wei Y, Li J, Huang J, Zhang X, Zhao H, Cui C, Li Y, Hu S - J. Cell. Mol. Med. (2012)

Histopathological analysis of IGF-2R. (A) Representative light microscopic findings in haematoxylin and eosin staining. The normal appearance of myocardial fibres with central nuclei is seen in non-failing control hearts (NF) and interstitial fibrosis replacement is found in DCM failing hearts (DCM-HF). (B) Representative light microscopic IGF-2R immunoreactivity using a monoclonal antibody, which recognizes IGF-2R. Few and weak immunoreactivity of IGF-2R is observed in non-failing control hearts (NF), but more and strong IGF-2R immunoreactivity can be seen in DCM failing hearts (DCM-HF). Arrows indicated the positive staining.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4365882&req=5

fig02: Histopathological analysis of IGF-2R. (A) Representative light microscopic findings in haematoxylin and eosin staining. The normal appearance of myocardial fibres with central nuclei is seen in non-failing control hearts (NF) and interstitial fibrosis replacement is found in DCM failing hearts (DCM-HF). (B) Representative light microscopic IGF-2R immunoreactivity using a monoclonal antibody, which recognizes IGF-2R. Few and weak immunoreactivity of IGF-2R is observed in non-failing control hearts (NF), but more and strong IGF-2R immunoreactivity can be seen in DCM failing hearts (DCM-HF). Arrows indicated the positive staining.
Mentions: Interstitial fibrosis in DCM-HF was observed compared with NF in the HE staining (Fig. 2A). In the immunohistochemical staining, the control specimens from NF exhibited few and weak IGF-2R immunoreactivity. In contrast, more and strong IGF-2R immunoreactivity was observed in DCM-HF (Fig. 2B).

Bottom Line: Cardiac IGF-2R levels increased in end-stage HF patients (n = 11) compared with non-failing control subjects.Leu27-IGF-2, an IGF-2 analogue to activate specially the IGF-2R, could induce apoptosis and reactive oxygen species production in neonatal rat ventricular myocytes.The serum IGF-2R levels were significantly higher in HF patients than those in non-failing control subjects.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. weiyingjiefw@126.com

Show MeSH
Related in: MedlinePlus