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Adult onset asynchronous multifocal eosinophilic granuloma of bone: an 11-year follow-up.

Dallaudière B, Kerger J, Malghem J, Galant C, Lecouvet FE - Acta Radiol Open (2015)

Bottom Line: Multifocal eosinophilic granuloma (EG) is a rare observation within the spectrum of histiocytosis X, generally described in children.We report the case of a 33-year-old man with multifocal EG showing an asynchronous evolution of bone lesions during a follow-up of 11 years.We also present the therapeutic approach chosen for this patient and the repeated magnetic resonance imaging (MRI) examinations used to monitor the disease with a final favorable outcome.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Centre du Cancer et Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.

ABSTRACT
Multifocal eosinophilic granuloma (EG) is a rare observation within the spectrum of histiocytosis X, generally described in children. We report the case of a 33-year-old man with multifocal EG showing an asynchronous evolution of bone lesions during a follow-up of 11 years. We also present the therapeutic approach chosen for this patient and the repeated magnetic resonance imaging (MRI) examinations used to monitor the disease with a final favorable outcome.

No MeSH data available.


Related in: MedlinePlus

(a, b) Sagittal T1W MRI sequence shows bone marrow replacement and in T3, with small vertebral deformity (arrow in a) and in the L5 vertebral body (arrow head in b).
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fig4-2047981614552217: (a, b) Sagittal T1W MRI sequence shows bone marrow replacement and in T3, with small vertebral deformity (arrow in a) and in the L5 vertebral body (arrow head in b).

Mentions: Initial imaging work-up included Technetium99 m bone scintigraphy (BS) and radiographs of the thoracic girdle. The BS showed increased uptake in the mid-portion of the eighth right rib and in the posterior aspect of the eighth left rib with no abnormalities in the cervical spine. Radiographs confirmed these lesions and revealed a recent pathological fracture of the eighth left rib and also an older fracture of the eighth right rib with osteosclerosis and periosteal reactions (Fig. 1a–c). A computed tomography (CT) scan showed a healing process in the eighth right rib, large osteolysis in the eighth left rib, but also an incidental asymptomatic osteolysis in the posterior arch of seventh cervical vertebra (C7), in the manubrium sterni and in the left iliac bone (Fig. 2a–c). MRI was performed to characterize these lesions, which consisted of bone marrow replacement with decreased signal intensity on T1-weighted (T1W) images and increased signal intensity on T2-weighted (T2W) images. MRI also revealed asymptomatic foci of marrow replacement in the T3, T11, and L5 vertebral bodies and in the right femoral neck (Figs. 3 and 4).Fig. 1.


Adult onset asynchronous multifocal eosinophilic granuloma of bone: an 11-year follow-up.

Dallaudière B, Kerger J, Malghem J, Galant C, Lecouvet FE - Acta Radiol Open (2015)

(a, b) Sagittal T1W MRI sequence shows bone marrow replacement and in T3, with small vertebral deformity (arrow in a) and in the L5 vertebral body (arrow head in b).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4364399&req=5

fig4-2047981614552217: (a, b) Sagittal T1W MRI sequence shows bone marrow replacement and in T3, with small vertebral deformity (arrow in a) and in the L5 vertebral body (arrow head in b).
Mentions: Initial imaging work-up included Technetium99 m bone scintigraphy (BS) and radiographs of the thoracic girdle. The BS showed increased uptake in the mid-portion of the eighth right rib and in the posterior aspect of the eighth left rib with no abnormalities in the cervical spine. Radiographs confirmed these lesions and revealed a recent pathological fracture of the eighth left rib and also an older fracture of the eighth right rib with osteosclerosis and periosteal reactions (Fig. 1a–c). A computed tomography (CT) scan showed a healing process in the eighth right rib, large osteolysis in the eighth left rib, but also an incidental asymptomatic osteolysis in the posterior arch of seventh cervical vertebra (C7), in the manubrium sterni and in the left iliac bone (Fig. 2a–c). MRI was performed to characterize these lesions, which consisted of bone marrow replacement with decreased signal intensity on T1-weighted (T1W) images and increased signal intensity on T2-weighted (T2W) images. MRI also revealed asymptomatic foci of marrow replacement in the T3, T11, and L5 vertebral bodies and in the right femoral neck (Figs. 3 and 4).Fig. 1.

Bottom Line: Multifocal eosinophilic granuloma (EG) is a rare observation within the spectrum of histiocytosis X, generally described in children.We report the case of a 33-year-old man with multifocal EG showing an asynchronous evolution of bone lesions during a follow-up of 11 years.We also present the therapeutic approach chosen for this patient and the repeated magnetic resonance imaging (MRI) examinations used to monitor the disease with a final favorable outcome.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Centre du Cancer et Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.

ABSTRACT
Multifocal eosinophilic granuloma (EG) is a rare observation within the spectrum of histiocytosis X, generally described in children. We report the case of a 33-year-old man with multifocal EG showing an asynchronous evolution of bone lesions during a follow-up of 11 years. We also present the therapeutic approach chosen for this patient and the repeated magnetic resonance imaging (MRI) examinations used to monitor the disease with a final favorable outcome.

No MeSH data available.


Related in: MedlinePlus