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α-2-macroglobulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus.

Aitken JP, Ortiz C, Morales-Bozo I, Rojas-Alcayaga G, Baeza M, Beltran C, Escobar A - Dis. Markers (2015)

Bottom Line: Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients. 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group).Area under the receivers operating characteristic (ROC) curve of α-2-macroglobulin indicated a positive discrimination threshold of α-2-macroglobulin (AUC = 0.903, CI 95%: 0.847-0.959, P < 0.0001) to diagnose glycemic control.Our data strongly suggest that the level of saliva α-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile.

ABSTRACT

Background: Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients.

Methods: 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between α-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated.

Results: We found a positive correlation between α-2-macroglobulin and HbA1c (r = 0.778 and P < 0.0001). Area under the receivers operating characteristic (ROC) curve of α-2-macroglobulin indicated a positive discrimination threshold of α-2-macroglobulin (AUC = 0.903, CI 95%: 0.847-0.959, P < 0.0001) to diagnose glycemic control.

Conclusions: Our data strongly suggest that the level of saliva α-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.

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Scatter diagram showing the association between HbA1 percentage and saliva levels of A2MG based on Pearson's correlation analysis.
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fig2: Scatter diagram showing the association between HbA1 percentage and saliva levels of A2MG based on Pearson's correlation analysis.

Mentions: Using Spearman correlation analysis we found a correlation between saliva levels of A2MG and HbA1c percentage (r = 0.7748 and  P < 0.0001) in patients with DM2 (Figure 2).


α-2-macroglobulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus.

Aitken JP, Ortiz C, Morales-Bozo I, Rojas-Alcayaga G, Baeza M, Beltran C, Escobar A - Dis. Markers (2015)

Scatter diagram showing the association between HbA1 percentage and saliva levels of A2MG based on Pearson's correlation analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4363888&req=5

fig2: Scatter diagram showing the association between HbA1 percentage and saliva levels of A2MG based on Pearson's correlation analysis.
Mentions: Using Spearman correlation analysis we found a correlation between saliva levels of A2MG and HbA1c percentage (r = 0.7748 and  P < 0.0001) in patients with DM2 (Figure 2).

Bottom Line: Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients. 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group).Area under the receivers operating characteristic (ROC) curve of α-2-macroglobulin indicated a positive discrimination threshold of α-2-macroglobulin (AUC = 0.903, CI 95%: 0.847-0.959, P < 0.0001) to diagnose glycemic control.Our data strongly suggest that the level of saliva α-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Patología y Medicina oral, Facultad de Odontología, Universidad de Chile, 8380492 Santiago, Chile.

ABSTRACT

Background: Subjects with type 2 diabetes mellitus (DM2) require an adequate glycemic control to avoid diabetic complications. Currently, saliva biomarkers are used as a diagnostic tool and can be indicative of the degree of progression and control of various diseases. Several studies indicate that α-2-macroglobulin levels are elevated in diabetic patients.

Methods: 120 subjects with DM2 were enrolled and classified into two groups according to their glycemic control (percentage of glycated hemoglobin-A1c (HbA1c), <7% adequate glycemic control group; >7% inadequate glycemic control group). The relationship between α-2-macroglobulin levels from saliva samples and HbA1c was subsequently evaluated.

Results: We found a positive correlation between α-2-macroglobulin and HbA1c (r = 0.778 and P < 0.0001). Area under the receivers operating characteristic (ROC) curve of α-2-macroglobulin indicated a positive discrimination threshold of α-2-macroglobulin (AUC = 0.903, CI 95%: 0.847-0.959, P < 0.0001) to diagnose glycemic control.

Conclusions: Our data strongly suggest that the level of saliva α-2-macroglobulin is an indicator for the degree of glycemic control in diabetic patients and represents a promising alternative method to evaluate this parameter.

Show MeSH
Related in: MedlinePlus