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Effect of da-cheng-qi decoction on pancreatitis-associated intestinal dysmotility in patients and in rat models.

Zhao J, Zhong C, He Z, Chen G, Tang W - Evid Based Complement Alternat Med (2015)

Bottom Line: We also experimentally examined plasma inflammatory cytokines in rat serum and carried the morphometric studies of the gut.Though DCQD did not affect the overall incidence of organ failure, it shortened the average time of paralytic intestinal obstruction and decreased the morbidity of infectious complications in patients with SAP.In conclusion, DCQD has good effect on pancreatitis-associated intestinal dysmotility in patients and in rat models.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, School of Preclinical and Forensic Medicine, West China Medical Center, Sichuan University, Chengdu 610041, China.

ABSTRACT
The impairment of intestinal motility and related infectious complications are the predominant clinical phenomenon in patients with severe acute pancreatitis (SAP). We aimed to investigate the effects of Da-Cheng-Qi decoction (DCQD) on the gastrointestinal injury in SAP patients and the potential mechanism involved in rats. DCQD was enema administered to 70 patients for 7 days in West China Hospital. Mortality and organ failure during admission were observed and blood samples for laboratory analysis were collected. We also experimentally examined plasma inflammatory cytokines in rat serum and carried the morphometric studies of the gut. Intestinal propulsion index and serum and tissue vasoactive intestinal peptide (VIP) were also detected. Though DCQD did not affect the overall incidence of organ failure, it shortened the average time of paralytic intestinal obstruction and decreased the morbidity of infectious complications in patients with SAP. Compared with untreated rats, the DCQD lowered the levels of proinflammatory cytokine and decreased the mean pathological intestinal lesion scores. The VIP level in intestinal tissue or serum in DCQD group was obviously lowered and intestinal propulsion index was significantly improved. In conclusion, DCQD has good effect on pancreatitis-associated intestinal dysmotility in patients and in rat models.

No MeSH data available.


Related in: MedlinePlus

Effect of Da-Cheng-Qi decoction (DCQD) treatment on the mean duration of gastrointestinal failure in severe acute pancreatitis patients. *P < 0.05 versus control group (n = 70/DCQD group).
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fig3: Effect of Da-Cheng-Qi decoction (DCQD) treatment on the mean duration of gastrointestinal failure in severe acute pancreatitis patients. *P < 0.05 versus control group (n = 70/DCQD group).

Mentions: Although DCQD at the dose used in this study did not affect the overall percentage of patients with gastrointestinal failure (81% in DCQD group, compared with 69% in controls P > 0.05), it did shorten the average time of the gastrointestinal failure and paralytic intestinal obstruction: the mean duration of gastrointestinal failure in DCQD patients was 9.91 ± 4.59, compared with a mean duration of 13.67 ± 9.65 in controls (P < 0.05) (Figure 3).


Effect of da-cheng-qi decoction on pancreatitis-associated intestinal dysmotility in patients and in rat models.

Zhao J, Zhong C, He Z, Chen G, Tang W - Evid Based Complement Alternat Med (2015)

Effect of Da-Cheng-Qi decoction (DCQD) treatment on the mean duration of gastrointestinal failure in severe acute pancreatitis patients. *P < 0.05 versus control group (n = 70/DCQD group).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4363702&req=5

fig3: Effect of Da-Cheng-Qi decoction (DCQD) treatment on the mean duration of gastrointestinal failure in severe acute pancreatitis patients. *P < 0.05 versus control group (n = 70/DCQD group).
Mentions: Although DCQD at the dose used in this study did not affect the overall percentage of patients with gastrointestinal failure (81% in DCQD group, compared with 69% in controls P > 0.05), it did shorten the average time of the gastrointestinal failure and paralytic intestinal obstruction: the mean duration of gastrointestinal failure in DCQD patients was 9.91 ± 4.59, compared with a mean duration of 13.67 ± 9.65 in controls (P < 0.05) (Figure 3).

Bottom Line: We also experimentally examined plasma inflammatory cytokines in rat serum and carried the morphometric studies of the gut.Though DCQD did not affect the overall incidence of organ failure, it shortened the average time of paralytic intestinal obstruction and decreased the morbidity of infectious complications in patients with SAP.In conclusion, DCQD has good effect on pancreatitis-associated intestinal dysmotility in patients and in rat models.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, School of Preclinical and Forensic Medicine, West China Medical Center, Sichuan University, Chengdu 610041, China.

ABSTRACT
The impairment of intestinal motility and related infectious complications are the predominant clinical phenomenon in patients with severe acute pancreatitis (SAP). We aimed to investigate the effects of Da-Cheng-Qi decoction (DCQD) on the gastrointestinal injury in SAP patients and the potential mechanism involved in rats. DCQD was enema administered to 70 patients for 7 days in West China Hospital. Mortality and organ failure during admission were observed and blood samples for laboratory analysis were collected. We also experimentally examined plasma inflammatory cytokines in rat serum and carried the morphometric studies of the gut. Intestinal propulsion index and serum and tissue vasoactive intestinal peptide (VIP) were also detected. Though DCQD did not affect the overall incidence of organ failure, it shortened the average time of paralytic intestinal obstruction and decreased the morbidity of infectious complications in patients with SAP. Compared with untreated rats, the DCQD lowered the levels of proinflammatory cytokine and decreased the mean pathological intestinal lesion scores. The VIP level in intestinal tissue or serum in DCQD group was obviously lowered and intestinal propulsion index was significantly improved. In conclusion, DCQD has good effect on pancreatitis-associated intestinal dysmotility in patients and in rat models.

No MeSH data available.


Related in: MedlinePlus