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A genome-wide association study in large white and landrace pig populations for number piglets born alive.

Bergfelder-Drüing S, Grosse-Brinkhaus C, Lind B, Erbe M, Schellander K, Simianer H, Tholen E - PLoS ONE (2015)

Bottom Line: It is difficult to improve NBA because the heritability of the trait is low and it is governed by a high number of loci with low to moderate effects.In total, 17 different significant markers affecting NBA were found in regions with known effects on female reproduction.No overlapping significant chromosome areas or QTL between Large White and Landrace breed were detected.

View Article: PubMed Central - PubMed

Affiliation: Institute of Animal Science, Department of Animal Genetics, University of Bonn, Bonn, Germany.

ABSTRACT
The number of piglets born alive (NBA) per litter is one of the most important traits in pig breeding due to its influence on production efficiency. It is difficult to improve NBA because the heritability of the trait is low and it is governed by a high number of loci with low to moderate effects. To clarify the biological and genetic background of NBA, genome-wide association studies (GWAS) were performed using 4,012 Large White and Landrace pigs from herdbook and commercial breeding companies in Germany (3), Austria (1) and Switzerland (1). The animals were genotyped with the Illumina PorcineSNP60 BeadChip. Because of population stratifications within and between breeds, clusters were formed using the genetic distances between the populations. Five clusters for each breed were formed and analysed by GWAS approaches. In total, 17 different significant markers affecting NBA were found in regions with known effects on female reproduction. No overlapping significant chromosome areas or QTL between Large White and Landrace breed were detected.

No MeSH data available.


MDS Plot of Landrace population of 5 European breeding companies, circles indicate different clusters.
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pone.0117468.g004: MDS Plot of Landrace population of 5 European breeding companies, circles indicate different clusters.

Mentions: MDS plots were used to visualize the genomic distances between the animals (Figs. 2, 3, and 4). Fig. 2 revealed that the breeds LW and LR had a large genetic distance and should be regarded as more or less genetically disconnected. Each breed was analysed separately because of distinct genetic differences between LW and LR. Additionally performed visual inspections of the breed specific MDS plots of LW and LR populations led to various cluster definitions (Figs. 3, 4).


A genome-wide association study in large white and landrace pig populations for number piglets born alive.

Bergfelder-Drüing S, Grosse-Brinkhaus C, Lind B, Erbe M, Schellander K, Simianer H, Tholen E - PLoS ONE (2015)

MDS Plot of Landrace population of 5 European breeding companies, circles indicate different clusters.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363374&req=5

pone.0117468.g004: MDS Plot of Landrace population of 5 European breeding companies, circles indicate different clusters.
Mentions: MDS plots were used to visualize the genomic distances between the animals (Figs. 2, 3, and 4). Fig. 2 revealed that the breeds LW and LR had a large genetic distance and should be regarded as more or less genetically disconnected. Each breed was analysed separately because of distinct genetic differences between LW and LR. Additionally performed visual inspections of the breed specific MDS plots of LW and LR populations led to various cluster definitions (Figs. 3, 4).

Bottom Line: It is difficult to improve NBA because the heritability of the trait is low and it is governed by a high number of loci with low to moderate effects.In total, 17 different significant markers affecting NBA were found in regions with known effects on female reproduction.No overlapping significant chromosome areas or QTL between Large White and Landrace breed were detected.

View Article: PubMed Central - PubMed

Affiliation: Institute of Animal Science, Department of Animal Genetics, University of Bonn, Bonn, Germany.

ABSTRACT
The number of piglets born alive (NBA) per litter is one of the most important traits in pig breeding due to its influence on production efficiency. It is difficult to improve NBA because the heritability of the trait is low and it is governed by a high number of loci with low to moderate effects. To clarify the biological and genetic background of NBA, genome-wide association studies (GWAS) were performed using 4,012 Large White and Landrace pigs from herdbook and commercial breeding companies in Germany (3), Austria (1) and Switzerland (1). The animals were genotyped with the Illumina PorcineSNP60 BeadChip. Because of population stratifications within and between breeds, clusters were formed using the genetic distances between the populations. Five clusters for each breed were formed and analysed by GWAS approaches. In total, 17 different significant markers affecting NBA were found in regions with known effects on female reproduction. No overlapping significant chromosome areas or QTL between Large White and Landrace breed were detected.

No MeSH data available.