Limits...
The value of MRI in the diagnosis of primary biliary cirrhosis and assessment of liver fibrosis.

Meng Y, Liang Y, Liu M - PLoS ONE (2015)

Bottom Line: There were significant differences among the four histological stages based on the periportal halo sign (P=0.034), and the grading of the periportal halo sign was found to be significantly correlated with the histological stage (P<0.001).Grading of the periportal halo sign was significantly different at stage II versus III, and stage III versus IV; no significant difference was found between stages I and II.There were also no significant differences among the four histological states in the occurrence and size of enlarged lymph nodes (P=0.674 and P=0.394).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

ABSTRACT

Objectives: To evaluate MRI findings in patients with primary biliary cirrhosis (PBC) and to determine the value of MRI in the diagnosis of PBC and assessment of liver fibrosis.

Materials and methods: This study reviewed the prevalence of MRI abnormalities seen in 45 PBC patients in the past four years, including 33 patients who underwent liver biopsy. Correlation between the MRI findings and the pathological stage was determined.

Results: There were 33 patients who underwent liver biopsy. Twenty-five patients (75.8%) had non-homogeneous changes in the liver signal intensity, 25 (75.8%) had a periportal halo sign, and 29 (87.9%) had lymphadenopathy. The short axis of the enlarged lymph nodes was a mean of 1.2±0.3 cm. A strong positive correlation was observed between histological stage and the inhomogeneity of liver signal intensity (P<0.001). There were significant differences among the four histological stages based on the periportal halo sign (P=0.034), and the grading of the periportal halo sign was found to be significantly correlated with the histological stage (P<0.001). Grading of the periportal halo sign was significantly different at stage II versus III, and stage III versus IV; no significant difference was found between stages I and II. There were also no significant differences among the four histological states in the occurrence and size of enlarged lymph nodes (P=0.674 and P=0.394).

Conclusion: MRI is valuable in the diagnosis of PBC, and the periportal halo sign and liver signal intensity help to evaluate the degree of liver fibrosis.

Show MeSH

Related in: MedlinePlus

Halo sign grade at different histological stages.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4363325&req=5

pone.0120110.g010: Halo sign grade at different histological stages.

Mentions: The degree of the periportal halo signs was assessed and observed in 25 patients (75.8%). Eight patients (24.2%) were grade 0, with 3 at stage I and 5 at stage II. Patients at stage I and II mainly showed halo sign grade 0 and 1, patients at stage III mainly showed grade 2, and patients at stage IV all showed grade 3. There were significant differences among the four histological stages based on the periportal halo sign (P = 0.034), and the periportal halo sign grading was found to be significantly correlated with histological stages (r = 0.687, P<0.001)(Fig. 10). The periportal halo sign grading was significantly different at stage II versus III, and stage III versus IV. No significant difference was found between stages I and II.


The value of MRI in the diagnosis of primary biliary cirrhosis and assessment of liver fibrosis.

Meng Y, Liang Y, Liu M - PLoS ONE (2015)

Halo sign grade at different histological stages.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363325&req=5

pone.0120110.g010: Halo sign grade at different histological stages.
Mentions: The degree of the periportal halo signs was assessed and observed in 25 patients (75.8%). Eight patients (24.2%) were grade 0, with 3 at stage I and 5 at stage II. Patients at stage I and II mainly showed halo sign grade 0 and 1, patients at stage III mainly showed grade 2, and patients at stage IV all showed grade 3. There were significant differences among the four histological stages based on the periportal halo sign (P = 0.034), and the periportal halo sign grading was found to be significantly correlated with histological stages (r = 0.687, P<0.001)(Fig. 10). The periportal halo sign grading was significantly different at stage II versus III, and stage III versus IV. No significant difference was found between stages I and II.

Bottom Line: There were significant differences among the four histological stages based on the periportal halo sign (P=0.034), and the grading of the periportal halo sign was found to be significantly correlated with the histological stage (P<0.001).Grading of the periportal halo sign was significantly different at stage II versus III, and stage III versus IV; no significant difference was found between stages I and II.There were also no significant differences among the four histological states in the occurrence and size of enlarged lymph nodes (P=0.674 and P=0.394).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

ABSTRACT

Objectives: To evaluate MRI findings in patients with primary biliary cirrhosis (PBC) and to determine the value of MRI in the diagnosis of PBC and assessment of liver fibrosis.

Materials and methods: This study reviewed the prevalence of MRI abnormalities seen in 45 PBC patients in the past four years, including 33 patients who underwent liver biopsy. Correlation between the MRI findings and the pathological stage was determined.

Results: There were 33 patients who underwent liver biopsy. Twenty-five patients (75.8%) had non-homogeneous changes in the liver signal intensity, 25 (75.8%) had a periportal halo sign, and 29 (87.9%) had lymphadenopathy. The short axis of the enlarged lymph nodes was a mean of 1.2±0.3 cm. A strong positive correlation was observed between histological stage and the inhomogeneity of liver signal intensity (P<0.001). There were significant differences among the four histological stages based on the periportal halo sign (P=0.034), and the grading of the periportal halo sign was found to be significantly correlated with the histological stage (P<0.001). Grading of the periportal halo sign was significantly different at stage II versus III, and stage III versus IV; no significant difference was found between stages I and II. There were also no significant differences among the four histological states in the occurrence and size of enlarged lymph nodes (P=0.674 and P=0.394).

Conclusion: MRI is valuable in the diagnosis of PBC, and the periportal halo sign and liver signal intensity help to evaluate the degree of liver fibrosis.

Show MeSH
Related in: MedlinePlus