Limits...
Tumor grade of clear cell renal cell carcinoma assessed by contrast-enhanced computed tomography.

Ishigami K, Leite LV, Pakalniskis MG, Lee DK, Holanda DG, Kuehn DM - Springerplus (2014)

Bottom Line: CT findings and Fuhrman grade were compared.Thirty-eight of 43 (88.4%) infiltrative ccRCC were high grade (Fuhrman grades 3-4).Cystic ccRCC tends to be low grade.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 USA.

ABSTRACT
The purpose of this study was to clarify the association between CT findings and Fuhrman grade of clear cell renal cell carcinoma (ccRCC). The study group consisted of 214 surgically proven ccRCC in 214 patients. Contrast-enhanced CT studies were retrospectively assessed for tumor size, cystic versus solid, calcification, heterogeneity of lesions, percentage of non-enhancing (necrotic) areas, and growth pattern. CT findings and Fuhrman grade were compared. Nineteen of 22 (86.4%) cystic ccRCC were low grade (Fuhrman grades 1-2). There was no significant correlation between tumor size and grade in cystic ccRCC (P = 0.43). In predominantly solid ccRCC, there was significant correlation between tumor size and grade (P < 0.0001). Thirty-eight of 43 (88.4%) infiltrative ccRCC were high grade (Fuhrman grades 3-4). Logistic regression showed tumor size and infiltrative growth were significantly associated with grades 3-4 (P = 0.00083 and P = 0.0059). Cystic ccRCC tends to be low grade. Infiltrative growth and larger tumor size may increase the likelihood of high grade ccRCC.

No MeSH data available.


Related in: MedlinePlus

Relationship between tumor size and Fuhrman grade in cystic ccRCC (a) and predominantly solid ccRCC (b). a: The X-axis is tumor size (cm), and the Y-axis is Fuhrman grade (1–4). The figure shows scatter graph and the fitted line. In cystic ccRCC, there is no significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was -0.179 (P =0.43). b: Scatter graph and the fitted line of predominantly solid ccRCC. There is significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was 0.51 (P <0.0001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4363222&req=5

Fig6: Relationship between tumor size and Fuhrman grade in cystic ccRCC (a) and predominantly solid ccRCC (b). a: The X-axis is tumor size (cm), and the Y-axis is Fuhrman grade (1–4). The figure shows scatter graph and the fitted line. In cystic ccRCC, there is no significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was -0.179 (P =0.43). b: Scatter graph and the fitted line of predominantly solid ccRCC. There is significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was 0.51 (P <0.0001).

Mentions: In cystic ccRCC, there was no significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was -0.179 (P = 0.43, Figure 6a). By contrast, in predominantly solid ccRCC, there was significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was 0.51 (P <0.0001, Figure 6b).Figure 6


Tumor grade of clear cell renal cell carcinoma assessed by contrast-enhanced computed tomography.

Ishigami K, Leite LV, Pakalniskis MG, Lee DK, Holanda DG, Kuehn DM - Springerplus (2014)

Relationship between tumor size and Fuhrman grade in cystic ccRCC (a) and predominantly solid ccRCC (b). a: The X-axis is tumor size (cm), and the Y-axis is Fuhrman grade (1–4). The figure shows scatter graph and the fitted line. In cystic ccRCC, there is no significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was -0.179 (P =0.43). b: Scatter graph and the fitted line of predominantly solid ccRCC. There is significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was 0.51 (P <0.0001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363222&req=5

Fig6: Relationship between tumor size and Fuhrman grade in cystic ccRCC (a) and predominantly solid ccRCC (b). a: The X-axis is tumor size (cm), and the Y-axis is Fuhrman grade (1–4). The figure shows scatter graph and the fitted line. In cystic ccRCC, there is no significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was -0.179 (P =0.43). b: Scatter graph and the fitted line of predominantly solid ccRCC. There is significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was 0.51 (P <0.0001).
Mentions: In cystic ccRCC, there was no significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was -0.179 (P = 0.43, Figure 6a). By contrast, in predominantly solid ccRCC, there was significant correlation between tumor size and Fuhrman grade. Spearman’s rank correlation Rho was 0.51 (P <0.0001, Figure 6b).Figure 6

Bottom Line: CT findings and Fuhrman grade were compared.Thirty-eight of 43 (88.4%) infiltrative ccRCC were high grade (Fuhrman grades 3-4).Cystic ccRCC tends to be low grade.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 USA.

ABSTRACT
The purpose of this study was to clarify the association between CT findings and Fuhrman grade of clear cell renal cell carcinoma (ccRCC). The study group consisted of 214 surgically proven ccRCC in 214 patients. Contrast-enhanced CT studies were retrospectively assessed for tumor size, cystic versus solid, calcification, heterogeneity of lesions, percentage of non-enhancing (necrotic) areas, and growth pattern. CT findings and Fuhrman grade were compared. Nineteen of 22 (86.4%) cystic ccRCC were low grade (Fuhrman grades 1-2). There was no significant correlation between tumor size and grade in cystic ccRCC (P = 0.43). In predominantly solid ccRCC, there was significant correlation between tumor size and grade (P < 0.0001). Thirty-eight of 43 (88.4%) infiltrative ccRCC were high grade (Fuhrman grades 3-4). Logistic regression showed tumor size and infiltrative growth were significantly associated with grades 3-4 (P = 0.00083 and P = 0.0059). Cystic ccRCC tends to be low grade. Infiltrative growth and larger tumor size may increase the likelihood of high grade ccRCC.

No MeSH data available.


Related in: MedlinePlus