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Dopamine supersensitivity psychosis and dopamine partial agonist: a retrospective survey of failure of switching to aripiprazole in schizophrenia.

Takase M, Kanahara N, Oda Y, Kimura H, Watanabe H, Iyo M - J. Psychopharmacol. (Oxford) (2015)

Bottom Line: We conducted a retrospective investigation for 264 patients whose treatment medication was switched to ARI from other antipsychotics.We divided the patients into the DSP(+) group with a history of DSP episode(s) (N = 70) and the DSP(-) group without such a history (N = 194), and then compared the clinical factors relevant to the success or failure of the switch to ARI between them.Our findings suggest that patients who receive high dosages of antipsychotic drugs form overt or covert DSP and such state is highly associated with psychotic worsening following ARI treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.

No MeSH data available.


Related in: MedlinePlus

Chlorpromazine-equivalent dose of antipsychotic(s) just prior to the aripiprazole initiation in each subgroup.
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fig3-0269881115570083: Chlorpromazine-equivalent dose of antipsychotic(s) just prior to the aripiprazole initiation in each subgroup.

Mentions: The chlorpromazine-equivalent dose (CPZeq-dose) just prior to the start of ARI adjunction in the DSP(+) group (762.4 ± 376.0 mg) was significantly higher than that in the DSP(–) group (473.5 ± 373.3 mg) (P < 0.01, Table 1). There were no significant differences in the dosages among the CON (734.3 ± 344.9 mg), D-OTH (807.6 ± 413.9 mg) and D-POS (673.9 ± 269.2 mg) patterns within the DSP(+) group (Figure 3). However, there was a significant difference among the CON (425.2 ± 340.1 mg), D-OTH (496.6 ± 411.8 mg) and D-POS (662.7 ± 294.9 mg) patterns within the DSP(–) group (P = 0.048), and a post hoc Tukey test revealed that the dose in the D-POS subgroup was significantly higher than that of the CON subgroup within the DSP(–) group (P = 0.048) (Figure 3).


Dopamine supersensitivity psychosis and dopamine partial agonist: a retrospective survey of failure of switching to aripiprazole in schizophrenia.

Takase M, Kanahara N, Oda Y, Kimura H, Watanabe H, Iyo M - J. Psychopharmacol. (Oxford) (2015)

Chlorpromazine-equivalent dose of antipsychotic(s) just prior to the aripiprazole initiation in each subgroup.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC4363127&req=5

fig3-0269881115570083: Chlorpromazine-equivalent dose of antipsychotic(s) just prior to the aripiprazole initiation in each subgroup.
Mentions: The chlorpromazine-equivalent dose (CPZeq-dose) just prior to the start of ARI adjunction in the DSP(+) group (762.4 ± 376.0 mg) was significantly higher than that in the DSP(–) group (473.5 ± 373.3 mg) (P < 0.01, Table 1). There were no significant differences in the dosages among the CON (734.3 ± 344.9 mg), D-OTH (807.6 ± 413.9 mg) and D-POS (673.9 ± 269.2 mg) patterns within the DSP(+) group (Figure 3). However, there was a significant difference among the CON (425.2 ± 340.1 mg), D-OTH (496.6 ± 411.8 mg) and D-POS (662.7 ± 294.9 mg) patterns within the DSP(–) group (P = 0.048), and a post hoc Tukey test revealed that the dose in the D-POS subgroup was significantly higher than that of the CON subgroup within the DSP(–) group (P = 0.048) (Figure 3).

Bottom Line: We conducted a retrospective investigation for 264 patients whose treatment medication was switched to ARI from other antipsychotics.We divided the patients into the DSP(+) group with a history of DSP episode(s) (N = 70) and the DSP(-) group without such a history (N = 194), and then compared the clinical factors relevant to the success or failure of the switch to ARI between them.Our findings suggest that patients who receive high dosages of antipsychotic drugs form overt or covert DSP and such state is highly associated with psychotic worsening following ARI treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.

No MeSH data available.


Related in: MedlinePlus