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Pharmacokinetics of metoclopramide in calves with renal dysfunction.

Takayasu M, Hamamoto K, Satoh H, Ichijo T, Takahashi T, Furuhama K - J. Vet. Med. Sci. (2014)

Bottom Line: Plasma MCP concentration, glomerular filtration rate (GFR) and plasma prolactin level were measured by liquid chromatography-tandem mass spectrometry, simplified equation using iodixanol and enzyme-linked immunosorbent assay, respectively.A tendency to increase in plasma PRL concentration was noted also in these calves.In conclusions, plasma MCP concentrations depend on the GFR mode in calves, and its critical GFR value was estimated.

View Article: PubMed Central - PubMed

Affiliation: Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan.

ABSTRACT
To clarify the effect of renal dysfunction on pharmacokinetics of the prokinetic agent metoclopramide (MCP), we administered intravenously 0.4 mg/kg MCP to healthy calves and calves subjected to right kidney vessel ligation (ligation) without or with a subsequent left nephrectomy (ligation plus removal). Plasma MCP concentration, glomerular filtration rate (GFR) and plasma prolactin level were measured by liquid chromatography-tandem mass spectrometry, simplified equation using iodixanol and enzyme-linked immunosorbent assay, respectively. Only in calves with ligation plus removal, plasma MCP concentrations were increased significantly 6, 8 and 12 hr after injection, showing that a negative correlation was observed between the plasma MCP concentrations and GFR value. A tendency to increase in plasma PRL concentration was noted also in these calves. In conclusions, plasma MCP concentrations depend on the GFR mode in calves, and its critical GFR value was estimated.

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Related in: MedlinePlus

Plots between plasma metoclopramide (MCP) concentration and glomerular filtration rate (GFR) in healthy calves (open circles) and calves subjected to right kidney vessel ligation (ligation, closed circles) without or with a subsequent left nephrectomy (ligation plus removal, closed squares). Plasma MCP concentrations 6, 8 and 12 hr after MCP injection were used, and the GFR was estimated before MCP injection. One calf with ligation plus removal was deleted from the analysis, because of an iodixanol injection error (sample number: 11, where the number elicits the sum of the individual data collected from different models on different days).
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fig_001: Plots between plasma metoclopramide (MCP) concentration and glomerular filtration rate (GFR) in healthy calves (open circles) and calves subjected to right kidney vessel ligation (ligation, closed circles) without or with a subsequent left nephrectomy (ligation plus removal, closed squares). Plasma MCP concentrations 6, 8 and 12 hr after MCP injection were used, and the GFR was estimated before MCP injection. One calf with ligation plus removal was deleted from the analysis, because of an iodixanol injection error (sample number: 11, where the number elicits the sum of the individual data collected from different models on different days).

Mentions: Data represent the mean ± SD, *P<0.05, **P<0.01 vs. healthy control.


Pharmacokinetics of metoclopramide in calves with renal dysfunction.

Takayasu M, Hamamoto K, Satoh H, Ichijo T, Takahashi T, Furuhama K - J. Vet. Med. Sci. (2014)

Plots between plasma metoclopramide (MCP) concentration and glomerular filtration rate (GFR) in healthy calves (open circles) and calves subjected to right kidney vessel ligation (ligation, closed circles) without or with a subsequent left nephrectomy (ligation plus removal, closed squares). Plasma MCP concentrations 6, 8 and 12 hr after MCP injection were used, and the GFR was estimated before MCP injection. One calf with ligation plus removal was deleted from the analysis, because of an iodixanol injection error (sample number: 11, where the number elicits the sum of the individual data collected from different models on different days).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363034&req=5

fig_001: Plots between plasma metoclopramide (MCP) concentration and glomerular filtration rate (GFR) in healthy calves (open circles) and calves subjected to right kidney vessel ligation (ligation, closed circles) without or with a subsequent left nephrectomy (ligation plus removal, closed squares). Plasma MCP concentrations 6, 8 and 12 hr after MCP injection were used, and the GFR was estimated before MCP injection. One calf with ligation plus removal was deleted from the analysis, because of an iodixanol injection error (sample number: 11, where the number elicits the sum of the individual data collected from different models on different days).
Mentions: Data represent the mean ± SD, *P<0.05, **P<0.01 vs. healthy control.

Bottom Line: Plasma MCP concentration, glomerular filtration rate (GFR) and plasma prolactin level were measured by liquid chromatography-tandem mass spectrometry, simplified equation using iodixanol and enzyme-linked immunosorbent assay, respectively.A tendency to increase in plasma PRL concentration was noted also in these calves.In conclusions, plasma MCP concentrations depend on the GFR mode in calves, and its critical GFR value was estimated.

View Article: PubMed Central - PubMed

Affiliation: Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan.

ABSTRACT
To clarify the effect of renal dysfunction on pharmacokinetics of the prokinetic agent metoclopramide (MCP), we administered intravenously 0.4 mg/kg MCP to healthy calves and calves subjected to right kidney vessel ligation (ligation) without or with a subsequent left nephrectomy (ligation plus removal). Plasma MCP concentration, glomerular filtration rate (GFR) and plasma prolactin level were measured by liquid chromatography-tandem mass spectrometry, simplified equation using iodixanol and enzyme-linked immunosorbent assay, respectively. Only in calves with ligation plus removal, plasma MCP concentrations were increased significantly 6, 8 and 12 hr after injection, showing that a negative correlation was observed between the plasma MCP concentrations and GFR value. A tendency to increase in plasma PRL concentration was noted also in these calves. In conclusions, plasma MCP concentrations depend on the GFR mode in calves, and its critical GFR value was estimated.

Show MeSH
Related in: MedlinePlus