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Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret.

Inoue S, Yonemaru K, Yanai T, Sakai H - J. Vet. Med. Sci. (2014)

Bottom Line: A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region.In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass.Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

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Immunohistochemistry of WT-1. Sertoli cells were nuclear positive for WT-1. Germ cells were negative for WT-1 (arrowheads). Bar=50 µm.
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fig_009: Immunohistochemistry of WT-1. Sertoli cells were nuclear positive for WT-1. Germ cells were negative for WT-1 (arrowheads). Bar=50 µm.

Mentions: Immunohistochemistry of c-kit. Germ cells were membranous positive for c-kit in the cytoplasm. Sertoli cells were negative for c-kit (arrowheads). Bar=50 µm.


Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret.

Inoue S, Yonemaru K, Yanai T, Sakai H - J. Vet. Med. Sci. (2014)

Immunohistochemistry of WT-1. Sertoli cells were nuclear positive for WT-1. Germ cells were negative for WT-1 (arrowheads). Bar=50 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363027&req=5

fig_009: Immunohistochemistry of WT-1. Sertoli cells were nuclear positive for WT-1. Germ cells were negative for WT-1 (arrowheads). Bar=50 µm.
Mentions: Immunohistochemistry of c-kit. Germ cells were membranous positive for c-kit in the cytoplasm. Sertoli cells were negative for c-kit (arrowheads). Bar=50 µm.

Bottom Line: A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region.In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass.Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

Show MeSH
Related in: MedlinePlus