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Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret.

Inoue S, Yonemaru K, Yanai T, Sakai H - J. Vet. Med. Sci. (2014)

Bottom Line: Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected.In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass.Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

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Immunohistochemistry of c-kit. Germ cells were membranous positive for c-kit in the cytoplasm. Sertoli cells were negative for c-kit (arrowheads). Bar=50 µm.
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fig_008: Immunohistochemistry of c-kit. Germ cells were membranous positive for c-kit in the cytoplasm. Sertoli cells were negative for c-kit (arrowheads). Bar=50 µm.

Mentions: The histopathological results revealed that the left testis was replaced entirely by neoplastic tissue. The neoplasm consisted of a diffuse intimately admixed proliferation of germ cell-like cells and Sertoli cell-like cells (Figs. 2 and 3). The former were large round cells that possessed abundant clear cytoplasm, large round to ovoid nuclei with one or two prominent large nucleoli and c-kit positive membranes (Fig. 8Fig. 8.


Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret.

Inoue S, Yonemaru K, Yanai T, Sakai H - J. Vet. Med. Sci. (2014)

Immunohistochemistry of c-kit. Germ cells were membranous positive for c-kit in the cytoplasm. Sertoli cells were negative for c-kit (arrowheads). Bar=50 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363027&req=5

fig_008: Immunohistochemistry of c-kit. Germ cells were membranous positive for c-kit in the cytoplasm. Sertoli cells were negative for c-kit (arrowheads). Bar=50 µm.
Mentions: The histopathological results revealed that the left testis was replaced entirely by neoplastic tissue. The neoplasm consisted of a diffuse intimately admixed proliferation of germ cell-like cells and Sertoli cell-like cells (Figs. 2 and 3). The former were large round cells that possessed abundant clear cytoplasm, large round to ovoid nuclei with one or two prominent large nucleoli and c-kit positive membranes (Fig. 8Fig. 8.

Bottom Line: Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected.In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass.Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

Show MeSH
Related in: MedlinePlus