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Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret.

Inoue S, Yonemaru K, Yanai T, Sakai H - J. Vet. Med. Sci. (2014)

Bottom Line: Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected.In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass.Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

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Histopathological findings of MGSCT. Diffuse proliferation of large round germ cells characterized by abundant clear cytoplasm and large round to ovoid nuclei with one or two prominent large nucleoli (arrowheads) and spindle to polygonal Sertoli cells with scant cytoplasm and oval to spindle nuclei including obvious nucleoli (arrows). Mitoses were scattered. Bar=50 µm.
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fig_003: Histopathological findings of MGSCT. Diffuse proliferation of large round germ cells characterized by abundant clear cytoplasm and large round to ovoid nuclei with one or two prominent large nucleoli (arrowheads) and spindle to polygonal Sertoli cells with scant cytoplasm and oval to spindle nuclei including obvious nucleoli (arrows). Mitoses were scattered. Bar=50 µm.

Mentions: The histopathological results revealed that the left testis was replaced entirely by neoplastic tissue. The neoplasm consisted of a diffuse intimately admixed proliferation of germ cell-like cells and Sertoli cell-like cells (Figs. 2 and 3). The former were large round cells that possessed abundant clear cytoplasm, large round to ovoid nuclei with one or two prominent large nucleoli and c-kit positive membranes (Fig. 8Fig. 8.


Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret.

Inoue S, Yonemaru K, Yanai T, Sakai H - J. Vet. Med. Sci. (2014)

Histopathological findings of MGSCT. Diffuse proliferation of large round germ cells characterized by abundant clear cytoplasm and large round to ovoid nuclei with one or two prominent large nucleoli (arrowheads) and spindle to polygonal Sertoli cells with scant cytoplasm and oval to spindle nuclei including obvious nucleoli (arrows). Mitoses were scattered. Bar=50 µm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363027&req=5

fig_003: Histopathological findings of MGSCT. Diffuse proliferation of large round germ cells characterized by abundant clear cytoplasm and large round to ovoid nuclei with one or two prominent large nucleoli (arrowheads) and spindle to polygonal Sertoli cells with scant cytoplasm and oval to spindle nuclei including obvious nucleoli (arrows). Mitoses were scattered. Bar=50 µm.
Mentions: The histopathological results revealed that the left testis was replaced entirely by neoplastic tissue. The neoplasm consisted of a diffuse intimately admixed proliferation of germ cell-like cells and Sertoli cell-like cells (Figs. 2 and 3). The former were large round cells that possessed abundant clear cytoplasm, large round to ovoid nuclei with one or two prominent large nucleoli and c-kit positive membranes (Fig. 8Fig. 8.

Bottom Line: Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected.In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass.Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

Show MeSH
Related in: MedlinePlus