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Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret.

Inoue S, Yonemaru K, Yanai T, Sakai H - J. Vet. Med. Sci. (2014)

Bottom Line: Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected.In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass.Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

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Gross findings. The cut surface revealed pale yellow, partially tan to brown or dark red areas, which corresponded to interstitial tumor cells (arrowheads). Some cystic cavities were also observed. Scale=5 mm.
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fig_001: Gross findings. The cut surface revealed pale yellow, partially tan to brown or dark red areas, which corresponded to interstitial tumor cells (arrowheads). Some cystic cavities were also observed. Scale=5 mm.

Mentions: Gross examination revealed that the tumor was 6.5 × 5.5 cm in size, firm and irregularly round in shape. The cut surface revealed whitish yellow, partially brown and dark red areas which was suspected as hemorrhage (Fig.1). Likewise, a number of cystic cavities were observed at the cut surface.


Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret.

Inoue S, Yonemaru K, Yanai T, Sakai H - J. Vet. Med. Sci. (2014)

Gross findings. The cut surface revealed pale yellow, partially tan to brown or dark red areas, which corresponded to interstitial tumor cells (arrowheads). Some cystic cavities were also observed. Scale=5 mm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363027&req=5

fig_001: Gross findings. The cut surface revealed pale yellow, partially tan to brown or dark red areas, which corresponded to interstitial tumor cells (arrowheads). Some cystic cavities were also observed. Scale=5 mm.
Mentions: Gross examination revealed that the tumor was 6.5 × 5.5 cm in size, firm and irregularly round in shape. The cut surface revealed whitish yellow, partially brown and dark red areas which was suspected as hemorrhage (Fig.1). Likewise, a number of cystic cavities were observed at the cut surface.

Bottom Line: Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected.In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass.Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

ABSTRACT
A 5-year-old male ferret presented with an enlarged canalicular testis in the left inguinal region. Microscopically, the enlarged testis consisted of a diffuse intimately admixed proliferation of c-kit-positive germ cell-like and Wilms tumor-1 protein-positive Sertoli cell-like components, but no Call-Exner body was detected. In addition, the compact proliferation of steroidogenic acute regulatory protein-intense positive interstitial cells was identified in a separate peripheral area of the mass. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as a mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor.

Show MeSH
Related in: MedlinePlus