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Electroacupuncture at the Zusanli and Baihui acupoints ameliorates type-2 diabetes-induced reductions in proliferating cells and differentiated neuroblasts in the hippocampal dentate gyrus with increasing brain-derived neurotrophic factor levels.

Chung JY, Yoo DY, Im W, Choi JH, Yi SS, Youn HY, Hwang IK, Seong JK, Yoon YS - J. Vet. Med. Sci. (2014)

Bottom Line: In contrast, proliferating cells and differentiated neuroblasts were significantly decreased in the ZDF-Sham group compared to the ZLC group.Although EA treatment decreased blood glucose levels, this was not statistically significant when compared to blood glucose levels changes in the ZDF-Sham group.Brain-derived neurotrophic factor (BDNF) levels were significantly decreased in hippocampal homogenates of ZDF-Sham group compared to those in the ZLC group.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Internal Medicine and Geriatrics, College of Veterinary Medicine, Kangwon National University, Chuncheon 200-701, Republic of Korea.

ABSTRACT
In the current study, we investigated whether electroacupuncture (EA) can inhibit pathological reductions in neurogenesis. Zucker diabetic fatty (ZDF) rats at 7 weeks of age were anesthetized with zoletil, and sham-acupuncture or EA at the Zusanli (ST36) and Baihui (GV20) acupoints was administered once a day for 5 weeks. In the ZDF group that received sham-EA (ZDF-Sham group), the blood glucose level was significantly increased together with age as compared to the control littermates [Zucker lean control (ZLC) rat]. In contrast, proliferating cells and differentiated neuroblasts were significantly decreased in the ZDF-Sham group compared to the ZLC group. Although EA treatment decreased blood glucose levels, this was not statistically significant when compared to blood glucose levels changes in the ZDF-Sham group. However, proliferating cells and differentiated neuroblasts were significantly increased with EA in ZDF rats as compared to those in the ZDF-Sham group. Brain-derived neurotrophic factor (BDNF) levels were significantly decreased in hippocampal homogenates of ZDF-Sham group compared to those in the ZLC group. The EA treatment significantly increased the BDNF levels compared to those in the ZDF-Sham group, and BDNF levels in this group were similar to those in the ZLC group. These results suggest that EA at ST36 and GV20 can ameliorate the reductions in proliferating cells and differentiated neuroblasts in the dentate gyrus induced by type-2 diabetes without significantly reducing blood glucose levels with increasing BDNF levels.

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Related in: MedlinePlus

BDNF levels in the hippocampi of ZLC, ZDF-Sham and ZDF-EA rats. Note that BDNF levels are significantly decreased in the ZDF-Sham group and reversed EA treatment (n=4 per group; *P<0.05, significantly different from the ZLC group, #P<0.05, significantly different from the ZDF-Sham group). Bars indicate means ± SEM.
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fig_004: BDNF levels in the hippocampi of ZLC, ZDF-Sham and ZDF-EA rats. Note that BDNF levels are significantly decreased in the ZDF-Sham group and reversed EA treatment (n=4 per group; *P<0.05, significantly different from the ZLC group, #P<0.05, significantly different from the ZDF-Sham group). Bars indicate means ± SEM.

Mentions: Effects of EA on BDNF levels at the onset of type-2 diabetes: In the ZLC group, BDNF levels were 17.08 ± 1.99 ng/g wet weight in the hippocampal homogenates. In the ZDF-Sham group, BDNF levels were significantly decreased to 67.1% of ZLC group. EA treatment to ZDF group significantly increased the BDNF levels, which were similar to those in the ZLC group (Fig. 4Fig. 4.


Electroacupuncture at the Zusanli and Baihui acupoints ameliorates type-2 diabetes-induced reductions in proliferating cells and differentiated neuroblasts in the hippocampal dentate gyrus with increasing brain-derived neurotrophic factor levels.

Chung JY, Yoo DY, Im W, Choi JH, Yi SS, Youn HY, Hwang IK, Seong JK, Yoon YS - J. Vet. Med. Sci. (2014)

BDNF levels in the hippocampi of ZLC, ZDF-Sham and ZDF-EA rats. Note that BDNF levels are significantly decreased in the ZDF-Sham group and reversed EA treatment (n=4 per group; *P<0.05, significantly different from the ZLC group, #P<0.05, significantly different from the ZDF-Sham group). Bars indicate means ± SEM.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4363018&req=5

fig_004: BDNF levels in the hippocampi of ZLC, ZDF-Sham and ZDF-EA rats. Note that BDNF levels are significantly decreased in the ZDF-Sham group and reversed EA treatment (n=4 per group; *P<0.05, significantly different from the ZLC group, #P<0.05, significantly different from the ZDF-Sham group). Bars indicate means ± SEM.
Mentions: Effects of EA on BDNF levels at the onset of type-2 diabetes: In the ZLC group, BDNF levels were 17.08 ± 1.99 ng/g wet weight in the hippocampal homogenates. In the ZDF-Sham group, BDNF levels were significantly decreased to 67.1% of ZLC group. EA treatment to ZDF group significantly increased the BDNF levels, which were similar to those in the ZLC group (Fig. 4Fig. 4.

Bottom Line: In contrast, proliferating cells and differentiated neuroblasts were significantly decreased in the ZDF-Sham group compared to the ZLC group.Although EA treatment decreased blood glucose levels, this was not statistically significant when compared to blood glucose levels changes in the ZDF-Sham group.Brain-derived neurotrophic factor (BDNF) levels were significantly decreased in hippocampal homogenates of ZDF-Sham group compared to those in the ZLC group.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Internal Medicine and Geriatrics, College of Veterinary Medicine, Kangwon National University, Chuncheon 200-701, Republic of Korea.

ABSTRACT
In the current study, we investigated whether electroacupuncture (EA) can inhibit pathological reductions in neurogenesis. Zucker diabetic fatty (ZDF) rats at 7 weeks of age were anesthetized with zoletil, and sham-acupuncture or EA at the Zusanli (ST36) and Baihui (GV20) acupoints was administered once a day for 5 weeks. In the ZDF group that received sham-EA (ZDF-Sham group), the blood glucose level was significantly increased together with age as compared to the control littermates [Zucker lean control (ZLC) rat]. In contrast, proliferating cells and differentiated neuroblasts were significantly decreased in the ZDF-Sham group compared to the ZLC group. Although EA treatment decreased blood glucose levels, this was not statistically significant when compared to blood glucose levels changes in the ZDF-Sham group. However, proliferating cells and differentiated neuroblasts were significantly increased with EA in ZDF rats as compared to those in the ZDF-Sham group. Brain-derived neurotrophic factor (BDNF) levels were significantly decreased in hippocampal homogenates of ZDF-Sham group compared to those in the ZLC group. The EA treatment significantly increased the BDNF levels compared to those in the ZDF-Sham group, and BDNF levels in this group were similar to those in the ZLC group. These results suggest that EA at ST36 and GV20 can ameliorate the reductions in proliferating cells and differentiated neuroblasts in the dentate gyrus induced by type-2 diabetes without significantly reducing blood glucose levels with increasing BDNF levels.

Show MeSH
Related in: MedlinePlus