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Intravenous contrast media application using cone-beam computed tomography in a rabbit model.

Kim MS, Kim BY, Choi HY, Choi YJ, Oh SH, Kang JH, Lee SR, Kang JH, Kim GT, Choi YS, Hwang EH - Imaging Sci Dent (2015)

Bottom Line: An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning.The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures.The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyung Hee University, Seoul, Korea.

ABSTRACT

Purpose: This study was performed to evaluate the feasibility of visualizing soft tissue lesions and vascular structures using contrast-enhanced cone-beam computed tomography (CE-CBCT) after the intravenous administration of a contrast medium in an animal model.

Materials and methods: CBCT was performed on six rabbits after a contrast medium was administered using an injection dose of 2 mL/kg body weight and an injection rate of 1 mL/s via the ear vein or femoral vein under general anesthesia. Artificial soft tissue lesions were created through the transplantation of autologous fatty tissue into the salivary gland. Volume rendering reconstruction, maximum intensity projection, and multiplanar reconstruction images were reconstructed and evaluated in order to visualize soft tissue contrast and vascular structures.

Results: The contrast enhancement of soft tissue was possible using all contrast medium injection parameters. An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning. Artificial soft tissue lesions were successfully created in the animals. The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures.

Conclusion: Despite limited soft tissue resolution, the opacification of vascular structures was observed and artificial soft tissue lesions were visualized with sufficient contrast to the surrounding structures. The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

No MeSH data available.


Related in: MedlinePlus

A. The CBCT images show the difference of value of contrast density before and after contrast media administration for the artificial lesion in salivary gland by transplantation of autogenous fatty tissue. B. The graph shows the comparison of contrast density between non-enhancement and type 3 contrast enhancement in salivary gland and artificial fatty lesion on the CBCT image.
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Figure 9: A. The CBCT images show the difference of value of contrast density before and after contrast media administration for the artificial lesion in salivary gland by transplantation of autogenous fatty tissue. B. The graph shows the comparison of contrast density between non-enhancement and type 3 contrast enhancement in salivary gland and artificial fatty lesion on the CBCT image.

Mentions: An artificial soft tissue lesion was successfully created in all six animals. None of the animals presented with any clinical abnormalities. The contrast enhancement of soft tissue was observed in all administrations of contrast medium. However, the optimal administration of contrast media for CE-CBCT was a 5-mL injection before exposure with a continuous 5-mL injection during scanning (Type 3 CE-CBCT). The contrast density values for the artificial lesion within the SMGs and the vascular structures of the carotid arteries and the nutrient vessels were nearly identical in all three modalities. However, sufficient opacification of the soft tissues and vascular structures only occurred in the Type 3 CE-CBCT procedure. The anatomy of the artificial soft tissue lesions was clearly visible. The contrast density value of the SMGs changed from 32 in non-enhanced CBCT to 319 in Type 3 CE-CBCT, while the contrast value of the artificial fatty lesions changed from -154 in non-enhanced CBCT to -125 in Type 3 CE-CBCT. The results of the measurements are given in Figure 9.


Intravenous contrast media application using cone-beam computed tomography in a rabbit model.

Kim MS, Kim BY, Choi HY, Choi YJ, Oh SH, Kang JH, Lee SR, Kang JH, Kim GT, Choi YS, Hwang EH - Imaging Sci Dent (2015)

A. The CBCT images show the difference of value of contrast density before and after contrast media administration for the artificial lesion in salivary gland by transplantation of autogenous fatty tissue. B. The graph shows the comparison of contrast density between non-enhancement and type 3 contrast enhancement in salivary gland and artificial fatty lesion on the CBCT image.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362989&req=5

Figure 9: A. The CBCT images show the difference of value of contrast density before and after contrast media administration for the artificial lesion in salivary gland by transplantation of autogenous fatty tissue. B. The graph shows the comparison of contrast density between non-enhancement and type 3 contrast enhancement in salivary gland and artificial fatty lesion on the CBCT image.
Mentions: An artificial soft tissue lesion was successfully created in all six animals. None of the animals presented with any clinical abnormalities. The contrast enhancement of soft tissue was observed in all administrations of contrast medium. However, the optimal administration of contrast media for CE-CBCT was a 5-mL injection before exposure with a continuous 5-mL injection during scanning (Type 3 CE-CBCT). The contrast density values for the artificial lesion within the SMGs and the vascular structures of the carotid arteries and the nutrient vessels were nearly identical in all three modalities. However, sufficient opacification of the soft tissues and vascular structures only occurred in the Type 3 CE-CBCT procedure. The anatomy of the artificial soft tissue lesions was clearly visible. The contrast density value of the SMGs changed from 32 in non-enhanced CBCT to 319 in Type 3 CE-CBCT, while the contrast value of the artificial fatty lesions changed from -154 in non-enhanced CBCT to -125 in Type 3 CE-CBCT. The results of the measurements are given in Figure 9.

Bottom Line: An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning.The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures.The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyung Hee University, Seoul, Korea.

ABSTRACT

Purpose: This study was performed to evaluate the feasibility of visualizing soft tissue lesions and vascular structures using contrast-enhanced cone-beam computed tomography (CE-CBCT) after the intravenous administration of a contrast medium in an animal model.

Materials and methods: CBCT was performed on six rabbits after a contrast medium was administered using an injection dose of 2 mL/kg body weight and an injection rate of 1 mL/s via the ear vein or femoral vein under general anesthesia. Artificial soft tissue lesions were created through the transplantation of autologous fatty tissue into the salivary gland. Volume rendering reconstruction, maximum intensity projection, and multiplanar reconstruction images were reconstructed and evaluated in order to visualize soft tissue contrast and vascular structures.

Results: The contrast enhancement of soft tissue was possible using all contrast medium injection parameters. An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning. Artificial soft tissue lesions were successfully created in the animals. The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures.

Conclusion: Despite limited soft tissue resolution, the opacification of vascular structures was observed and artificial soft tissue lesions were visualized with sufficient contrast to the surrounding structures. The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

No MeSH data available.


Related in: MedlinePlus