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Intravenous contrast media application using cone-beam computed tomography in a rabbit model.

Kim MS, Kim BY, Choi HY, Choi YJ, Oh SH, Kang JH, Lee SR, Kang JH, Kim GT, Choi YS, Hwang EH - Imaging Sci Dent (2015)

Bottom Line: An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning.The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures.The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyung Hee University, Seoul, Korea.

ABSTRACT

Purpose: This study was performed to evaluate the feasibility of visualizing soft tissue lesions and vascular structures using contrast-enhanced cone-beam computed tomography (CE-CBCT) after the intravenous administration of a contrast medium in an animal model.

Materials and methods: CBCT was performed on six rabbits after a contrast medium was administered using an injection dose of 2 mL/kg body weight and an injection rate of 1 mL/s via the ear vein or femoral vein under general anesthesia. Artificial soft tissue lesions were created through the transplantation of autologous fatty tissue into the salivary gland. Volume rendering reconstruction, maximum intensity projection, and multiplanar reconstruction images were reconstructed and evaluated in order to visualize soft tissue contrast and vascular structures.

Results: The contrast enhancement of soft tissue was possible using all contrast medium injection parameters. An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning. Artificial soft tissue lesions were successfully created in the animals. The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures.

Conclusion: Despite limited soft tissue resolution, the opacification of vascular structures was observed and artificial soft tissue lesions were visualized with sufficient contrast to the surrounding structures. The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

No MeSH data available.


Related in: MedlinePlus

A specially designed equipment is used for immobilization of the rabbit during the procedures.
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Figure 2: A specially designed equipment is used for immobilization of the rabbit during the procedures.

Mentions: Imaging was performed with a CBCT apparatus (Alphard Vega, Ashahi Roentgen Co., Kyoto, Japan). The exposure parameters were set at a tube voltage of 80 kVp, a tube current of 6 mA, and an exposure time of 17 seconds. The exposure area was set to be 200 mm in diameter and 179 mm in height, with a voxel size of 0.39 mm. In this device, the X-ray source rotates 360 degrees around the objects being imaged. The rabbits were immobilized by using specifically designed equipment that was constructed from acrylic resin for animal fixation (Fig. 2).


Intravenous contrast media application using cone-beam computed tomography in a rabbit model.

Kim MS, Kim BY, Choi HY, Choi YJ, Oh SH, Kang JH, Lee SR, Kang JH, Kim GT, Choi YS, Hwang EH - Imaging Sci Dent (2015)

A specially designed equipment is used for immobilization of the rabbit during the procedures.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362989&req=5

Figure 2: A specially designed equipment is used for immobilization of the rabbit during the procedures.
Mentions: Imaging was performed with a CBCT apparatus (Alphard Vega, Ashahi Roentgen Co., Kyoto, Japan). The exposure parameters were set at a tube voltage of 80 kVp, a tube current of 6 mA, and an exposure time of 17 seconds. The exposure area was set to be 200 mm in diameter and 179 mm in height, with a voxel size of 0.39 mm. In this device, the X-ray source rotates 360 degrees around the objects being imaged. The rabbits were immobilized by using specifically designed equipment that was constructed from acrylic resin for animal fixation (Fig. 2).

Bottom Line: An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning.The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures.The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyung Hee University, Seoul, Korea.

ABSTRACT

Purpose: This study was performed to evaluate the feasibility of visualizing soft tissue lesions and vascular structures using contrast-enhanced cone-beam computed tomography (CE-CBCT) after the intravenous administration of a contrast medium in an animal model.

Materials and methods: CBCT was performed on six rabbits after a contrast medium was administered using an injection dose of 2 mL/kg body weight and an injection rate of 1 mL/s via the ear vein or femoral vein under general anesthesia. Artificial soft tissue lesions were created through the transplantation of autologous fatty tissue into the salivary gland. Volume rendering reconstruction, maximum intensity projection, and multiplanar reconstruction images were reconstructed and evaluated in order to visualize soft tissue contrast and vascular structures.

Results: The contrast enhancement of soft tissue was possible using all contrast medium injection parameters. An adequate contrast medium injection parameter for facilitating effective CE-CBCT was a 5-mL injection before exposure combined with a continuous 5-mL injection during scanning. Artificial soft tissue lesions were successfully created in the animals. The CE-CBCT images demonstrated adequate opacification of the soft tissues and vascular structures.

Conclusion: Despite limited soft tissue resolution, the opacification of vascular structures was observed and artificial soft tissue lesions were visualized with sufficient contrast to the surrounding structures. The vascular structures and soft tissue lesions appeared well delineated in the CE-CBCT images, which was probably due to the superior spatial resolution of CE-CBCT compared to other techniques, such as multislice computed tomography.

No MeSH data available.


Related in: MedlinePlus