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Efficiency, safety, and patient preference of switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5% while maintaining the prostaglandin F2α analog.

Shimizu Y, Nakakura S, Nishiyama M, Tabuchi H, Kiuchi Y - Clin Ophthalmol (2015)

Bottom Line: In addition, no significant differences were found in the incidence of conjunctival hyperemia or SPK score at any time point (all P>0.5, by Kruskal-Wallis test).Based on the evaluation of side effects using the questionnaire, stinging/burning was less common (P=0.042), while blurred vision was more common (P=0.003), after switching to brinzolamide 1%/timolol 0.5%.Regarding patient preferences, 13 patients (31%) preferred dorzolamide 1%/timolol 0.5%, 12 patients (29%) preferred brinzolamide 1%/timolol 0.5%, and 17 patients (40%) preferred neither.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan.

ABSTRACT

Background: We investigated the efficiency, safety and patient preference of switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5% while maintaining the prostaglandin F2α analog.

Methods: We initially enrolled 44 eyes from 44 primary open angle glaucoma patients, and a total of 42 patients completed the study. All patients were under treatment with various prostaglandin F2α analogs and dorzolamide 1%/timolol 0.5%. While maintaining the prostaglandin F2α analog, dorzolamide 1%/timolol 0.5% was switched to brinzolamide 1%/timolol 0.5%. Conjunctival hyperemia, superficial punctate keratopathy, and intraocular pressure (IOP) were evaluated at baseline and at 4, 12, and 24 weeks. Adverse events and patient preferences, measured using a questionnaire at study initiation and at 24 weeks, were also noted.

Results: The IOP was 17.7±1.7, 16.8±2.6, 16.7±2.2, and 16.7±2.4 mmHg at baseline and at 4, 12, and 24 weeks, respectively, with no significant differences in IOP values at any time point (P=0.117, one-way analysis of variance). In addition, no significant differences were found in the incidence of conjunctival hyperemia or SPK score at any time point (all P>0.5, by Kruskal-Wallis test). Based on the evaluation of side effects using the questionnaire, stinging/burning was less common (P=0.042), while blurred vision was more common (P=0.003), after switching to brinzolamide 1%/timolol 0.5%. Regarding patient preferences, 13 patients (31%) preferred dorzolamide 1%/timolol 0.5%, 12 patients (29%) preferred brinzolamide 1%/timolol 0.5%, and 17 patients (40%) preferred neither.

Conclusion: When switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5%, the IOP values and incidence of superficial punctate keratopathy and conjunctival hyperemia were sustained throughout the 24-week observation period, and the patient preferences were similar for the two regimens. However, differences were observed in the ocular sensations of stinging/burning with dorzolamide 1%/timolol 0.5% and blurred vision with brinzolamide 1%/timolol 0.5%.

No MeSH data available.


Related in: MedlinePlus

Differences in IOP versus baseline. Almost three quarters of the patients were within 2 mmHg at each time point. The distribution of the three groups was similar during the follow-up period.Abbreviations: IOP, intraocular pressure; W, weeks.
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f3-opth-9-475: Differences in IOP versus baseline. Almost three quarters of the patients were within 2 mmHg at each time point. The distribution of the three groups was similar during the follow-up period.Abbreviations: IOP, intraocular pressure; W, weeks.

Mentions: The IOP was 17.7±1.7 (range 14–22) mmHg at baseline, 16.8±2.6 (range 11–24) mmHg at 4 weeks, 16.7±2.2 (range 12–25) mmHg at 12 weeks, and 16.7±2.4 (range 11–23) mmHg at 24 weeks. There were no significant differences between the time points (P=0.117, one-way analysis of variance, Figure 2). Further, we evaluated the differences in IOP between the baseline and follow-up visits. The IOP differences were classified into three groups, ie, within 2 mmHg, a <2 mmHg increase, and a <2 mmHg decrease. The distribution of IOP differences compared with baseline is shown in Figure 3. Almost three quarters of the patients were within 2 mmHg at each time point. The distribution of the three groups was similar during the follow-up period (P=0.821 by χ2 test).


Efficiency, safety, and patient preference of switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5% while maintaining the prostaglandin F2α analog.

Shimizu Y, Nakakura S, Nishiyama M, Tabuchi H, Kiuchi Y - Clin Ophthalmol (2015)

Differences in IOP versus baseline. Almost three quarters of the patients were within 2 mmHg at each time point. The distribution of the three groups was similar during the follow-up period.Abbreviations: IOP, intraocular pressure; W, weeks.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362984&req=5

f3-opth-9-475: Differences in IOP versus baseline. Almost three quarters of the patients were within 2 mmHg at each time point. The distribution of the three groups was similar during the follow-up period.Abbreviations: IOP, intraocular pressure; W, weeks.
Mentions: The IOP was 17.7±1.7 (range 14–22) mmHg at baseline, 16.8±2.6 (range 11–24) mmHg at 4 weeks, 16.7±2.2 (range 12–25) mmHg at 12 weeks, and 16.7±2.4 (range 11–23) mmHg at 24 weeks. There were no significant differences between the time points (P=0.117, one-way analysis of variance, Figure 2). Further, we evaluated the differences in IOP between the baseline and follow-up visits. The IOP differences were classified into three groups, ie, within 2 mmHg, a <2 mmHg increase, and a <2 mmHg decrease. The distribution of IOP differences compared with baseline is shown in Figure 3. Almost three quarters of the patients were within 2 mmHg at each time point. The distribution of the three groups was similar during the follow-up period (P=0.821 by χ2 test).

Bottom Line: In addition, no significant differences were found in the incidence of conjunctival hyperemia or SPK score at any time point (all P>0.5, by Kruskal-Wallis test).Based on the evaluation of side effects using the questionnaire, stinging/burning was less common (P=0.042), while blurred vision was more common (P=0.003), after switching to brinzolamide 1%/timolol 0.5%.Regarding patient preferences, 13 patients (31%) preferred dorzolamide 1%/timolol 0.5%, 12 patients (29%) preferred brinzolamide 1%/timolol 0.5%, and 17 patients (40%) preferred neither.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan.

ABSTRACT

Background: We investigated the efficiency, safety and patient preference of switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5% while maintaining the prostaglandin F2α analog.

Methods: We initially enrolled 44 eyes from 44 primary open angle glaucoma patients, and a total of 42 patients completed the study. All patients were under treatment with various prostaglandin F2α analogs and dorzolamide 1%/timolol 0.5%. While maintaining the prostaglandin F2α analog, dorzolamide 1%/timolol 0.5% was switched to brinzolamide 1%/timolol 0.5%. Conjunctival hyperemia, superficial punctate keratopathy, and intraocular pressure (IOP) were evaluated at baseline and at 4, 12, and 24 weeks. Adverse events and patient preferences, measured using a questionnaire at study initiation and at 24 weeks, were also noted.

Results: The IOP was 17.7±1.7, 16.8±2.6, 16.7±2.2, and 16.7±2.4 mmHg at baseline and at 4, 12, and 24 weeks, respectively, with no significant differences in IOP values at any time point (P=0.117, one-way analysis of variance). In addition, no significant differences were found in the incidence of conjunctival hyperemia or SPK score at any time point (all P>0.5, by Kruskal-Wallis test). Based on the evaluation of side effects using the questionnaire, stinging/burning was less common (P=0.042), while blurred vision was more common (P=0.003), after switching to brinzolamide 1%/timolol 0.5%. Regarding patient preferences, 13 patients (31%) preferred dorzolamide 1%/timolol 0.5%, 12 patients (29%) preferred brinzolamide 1%/timolol 0.5%, and 17 patients (40%) preferred neither.

Conclusion: When switching from dorzolamide 1%/timolol 0.5% to brinzolamide 1%/timolol 0.5%, the IOP values and incidence of superficial punctate keratopathy and conjunctival hyperemia were sustained throughout the 24-week observation period, and the patient preferences were similar for the two regimens. However, differences were observed in the ocular sensations of stinging/burning with dorzolamide 1%/timolol 0.5% and blurred vision with brinzolamide 1%/timolol 0.5%.

No MeSH data available.


Related in: MedlinePlus