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Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.

Syka M, Keller J, Klempíř J, Rulseh AM, Roth J, Jech R, Vorisek I, Vymazal J - PLoS ONE (2015)

Bottom Line: A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44).No correlation between MR and clinical parameters was found.Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.

ABSTRACT
Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the striatum. The main striatal output structure, the globus pallidus, strongly accumulates metalloprotein-bound iron, which was recently shown to influence the diffusion tensor scalar values. To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences. Quantitative magnetic resonance (MR), clinical and genetic data (number of CAG repeats) were obtained from 14 HD patients. MR parameters such as the T2 relaxation rate (RR), fractional anisotropy (FA) and mean diffusivity (MD) were analysed. A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44). A negative correlation was observed between RR and MD (R2=0.66). A trend towards correlation between CAG and MD was noted. No correlation between MR and clinical parameters was found. Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.

No MeSH data available.


Related in: MedlinePlus

MR data in HD patients and healthy controls.The comparison of the MR data obtained from the pallidum of HD patients with the MR data obtained from the pallidum of healthy controls; the corresponding medians and average standard deviations are included. Top: comparison of RR (1/T2), middle: comparison of FA, bottom: comparison of MD.
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pone.0118907.g004: MR data in HD patients and healthy controls.The comparison of the MR data obtained from the pallidum of HD patients with the MR data obtained from the pallidum of healthy controls; the corresponding medians and average standard deviations are included. Top: comparison of RR (1/T2), middle: comparison of FA, bottom: comparison of MD.

Mentions: No significant T2 relaxation time shortening (increase in RR) was found in the pallidum of HD patients compared to healthy controls (P>0.05). In addition to these relaxometry results, we also did not find any significant difference of FA and MD in the pallidum of HD patients compared to healthy controls (P>0.05). However, the RR, FA and MD data in patients were more scattered. These data are displayed in Fig. 4.


Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.

Syka M, Keller J, Klempíř J, Rulseh AM, Roth J, Jech R, Vorisek I, Vymazal J - PLoS ONE (2015)

MR data in HD patients and healthy controls.The comparison of the MR data obtained from the pallidum of HD patients with the MR data obtained from the pallidum of healthy controls; the corresponding medians and average standard deviations are included. Top: comparison of RR (1/T2), middle: comparison of FA, bottom: comparison of MD.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362949&req=5

pone.0118907.g004: MR data in HD patients and healthy controls.The comparison of the MR data obtained from the pallidum of HD patients with the MR data obtained from the pallidum of healthy controls; the corresponding medians and average standard deviations are included. Top: comparison of RR (1/T2), middle: comparison of FA, bottom: comparison of MD.
Mentions: No significant T2 relaxation time shortening (increase in RR) was found in the pallidum of HD patients compared to healthy controls (P>0.05). In addition to these relaxometry results, we also did not find any significant difference of FA and MD in the pallidum of HD patients compared to healthy controls (P>0.05). However, the RR, FA and MD data in patients were more scattered. These data are displayed in Fig. 4.

Bottom Line: A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44).No correlation between MR and clinical parameters was found.Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.

ABSTRACT
Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the striatum. The main striatal output structure, the globus pallidus, strongly accumulates metalloprotein-bound iron, which was recently shown to influence the diffusion tensor scalar values. To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences. Quantitative magnetic resonance (MR), clinical and genetic data (number of CAG repeats) were obtained from 14 HD patients. MR parameters such as the T2 relaxation rate (RR), fractional anisotropy (FA) and mean diffusivity (MD) were analysed. A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44). A negative correlation was observed between RR and MD (R2=0.66). A trend towards correlation between CAG and MD was noted. No correlation between MR and clinical parameters was found. Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.

No MeSH data available.


Related in: MedlinePlus