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Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.

Syka M, Keller J, Klempíř J, Rulseh AM, Roth J, Jech R, Vorisek I, Vymazal J - PLoS ONE (2015)

Bottom Line: To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences.A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44).No correlation between MR and clinical parameters was found.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.

ABSTRACT
Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the striatum. The main striatal output structure, the globus pallidus, strongly accumulates metalloprotein-bound iron, which was recently shown to influence the diffusion tensor scalar values. To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences. Quantitative magnetic resonance (MR), clinical and genetic data (number of CAG repeats) were obtained from 14 HD patients. MR parameters such as the T2 relaxation rate (RR), fractional anisotropy (FA) and mean diffusivity (MD) were analysed. A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44). A negative correlation was observed between RR and MD (R2=0.66). A trend towards correlation between CAG and MD was noted. No correlation between MR and clinical parameters was found. Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.

No MeSH data available.


Related in: MedlinePlus

Correlation of MR data and number of CAG triplets.The graphs show the correlation between the MR data obtained from the pallidum of HD patients and the number of CAG triplet repeats. Top: correlation between RR (1/T2) and CAG, bottom: correlation between FA and CAG.
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pone.0118907.g003: Correlation of MR data and number of CAG triplets.The graphs show the correlation between the MR data obtained from the pallidum of HD patients and the number of CAG triplet repeats. Top: correlation between RR (1/T2) and CAG, bottom: correlation between FA and CAG.

Mentions: The average number of CAG triplet repeats was 45.5 ± 3.5 (SD) with a range of 39–54. A positive linear relationship in the pallidum between the number of CAG triplet repeats and RR (R2 = 0.59, P<0.05, P<FDR) as well as between the number of CAG triplet repeats and FA (R2 = 0.44, P<0.05, P<FDR) was observed. These data are displayed in Fig. 3. After correction for multiple comparisons no significant correlation between the number of CAG triplet repeats and MD (R2 = 0.31, P<0.05, P>FDR) was noted. The average number of DBS was 381.6 ± 98.5 (SD) with a range of 203–573.5. A positive linear relationship between the DBS and RR (R2 = 0.45, P<0.05) as well as between the DBS and FA (R2 = 0.30, P<0.05 and no correlation between the DBS and MD (R2 = 0.14, P>0.05) was found.


Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.

Syka M, Keller J, Klempíř J, Rulseh AM, Roth J, Jech R, Vorisek I, Vymazal J - PLoS ONE (2015)

Correlation of MR data and number of CAG triplets.The graphs show the correlation between the MR data obtained from the pallidum of HD patients and the number of CAG triplet repeats. Top: correlation between RR (1/T2) and CAG, bottom: correlation between FA and CAG.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362949&req=5

pone.0118907.g003: Correlation of MR data and number of CAG triplets.The graphs show the correlation between the MR data obtained from the pallidum of HD patients and the number of CAG triplet repeats. Top: correlation between RR (1/T2) and CAG, bottom: correlation between FA and CAG.
Mentions: The average number of CAG triplet repeats was 45.5 ± 3.5 (SD) with a range of 39–54. A positive linear relationship in the pallidum between the number of CAG triplet repeats and RR (R2 = 0.59, P<0.05, P<FDR) as well as between the number of CAG triplet repeats and FA (R2 = 0.44, P<0.05, P<FDR) was observed. These data are displayed in Fig. 3. After correction for multiple comparisons no significant correlation between the number of CAG triplet repeats and MD (R2 = 0.31, P<0.05, P>FDR) was noted. The average number of DBS was 381.6 ± 98.5 (SD) with a range of 203–573.5. A positive linear relationship between the DBS and RR (R2 = 0.45, P<0.05) as well as between the DBS and FA (R2 = 0.30, P<0.05 and no correlation between the DBS and MD (R2 = 0.14, P>0.05) was found.

Bottom Line: To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences.A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44).No correlation between MR and clinical parameters was found.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.

ABSTRACT
Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the striatum. The main striatal output structure, the globus pallidus, strongly accumulates metalloprotein-bound iron, which was recently shown to influence the diffusion tensor scalar values. To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences. Quantitative magnetic resonance (MR), clinical and genetic data (number of CAG repeats) were obtained from 14 HD patients. MR parameters such as the T2 relaxation rate (RR), fractional anisotropy (FA) and mean diffusivity (MD) were analysed. A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44). A negative correlation was observed between RR and MD (R2=0.66). A trend towards correlation between CAG and MD was noted. No correlation between MR and clinical parameters was found. Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.

No MeSH data available.


Related in: MedlinePlus