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Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.

Syka M, Keller J, Klempíř J, Rulseh AM, Roth J, Jech R, Vorisek I, Vymazal J - PLoS ONE (2015)

Bottom Line: To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences.A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44).No correlation between MR and clinical parameters was found.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.

ABSTRACT
Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the striatum. The main striatal output structure, the globus pallidus, strongly accumulates metalloprotein-bound iron, which was recently shown to influence the diffusion tensor scalar values. To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences. Quantitative magnetic resonance (MR), clinical and genetic data (number of CAG repeats) were obtained from 14 HD patients. MR parameters such as the T2 relaxation rate (RR), fractional anisotropy (FA) and mean diffusivity (MD) were analysed. A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44). A negative correlation was observed between RR and MD (R2=0.66). A trend towards correlation between CAG and MD was noted. No correlation between MR and clinical parameters was found. Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.

No MeSH data available.


Related in: MedlinePlus

ROIs definition.The placement of the ROI masks on the CPMG sequence (right) and their projection on the co-registered MD map in an HD patient (left).
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pone.0118907.g001: ROIs definition.The placement of the ROI masks on the CPMG sequence (right) and their projection on the co-registered MD map in an HD patient (left).

Mentions: For T2 relaxometry the scanning protocol included a single slice Carr-Purcell-Meiboom-Gill-type (CPMG) multiple echo sequence, positioned on the axial plane approximately parallel to the plane passing through the anterior/posterior commissures to optimally cover the basal ganglia (Fig. 1). The parameters of the CPMG sequence were: 32 interecho times of 12.5, 25.0, 37.5 to 400.0 ms, TR = 3000 ms, FOV 230 mm, voxel size: 0.9 x 0.9 x 4 mm.


Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.

Syka M, Keller J, Klempíř J, Rulseh AM, Roth J, Jech R, Vorisek I, Vymazal J - PLoS ONE (2015)

ROIs definition.The placement of the ROI masks on the CPMG sequence (right) and their projection on the co-registered MD map in an HD patient (left).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362949&req=5

pone.0118907.g001: ROIs definition.The placement of the ROI masks on the CPMG sequence (right) and their projection on the co-registered MD map in an HD patient (left).
Mentions: For T2 relaxometry the scanning protocol included a single slice Carr-Purcell-Meiboom-Gill-type (CPMG) multiple echo sequence, positioned on the axial plane approximately parallel to the plane passing through the anterior/posterior commissures to optimally cover the basal ganglia (Fig. 1). The parameters of the CPMG sequence were: 32 interecho times of 12.5, 25.0, 37.5 to 400.0 ms, TR = 3000 ms, FOV 230 mm, voxel size: 0.9 x 0.9 x 4 mm.

Bottom Line: To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences.A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44).No correlation between MR and clinical parameters was found.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.

ABSTRACT
Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the striatum. The main striatal output structure, the globus pallidus, strongly accumulates metalloprotein-bound iron, which was recently shown to influence the diffusion tensor scalar values. To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences. Quantitative magnetic resonance (MR), clinical and genetic data (number of CAG repeats) were obtained from 14 HD patients. MR parameters such as the T2 relaxation rate (RR), fractional anisotropy (FA) and mean diffusivity (MD) were analysed. A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44). A negative correlation was observed between RR and MD (R2=0.66). A trend towards correlation between CAG and MD was noted. No correlation between MR and clinical parameters was found. Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.

No MeSH data available.


Related in: MedlinePlus