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Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically treated teeth.

Lechner J, von Baehr V - Int J Gen Med (2015)

Bottom Line: Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether.Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells.The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Integrative Dentistry, Munich, Germany.

ABSTRACT
Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings are correlated with semiquantitative values of a VSC indicator applied directly on endodontically treated teeth. Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells. The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

No MeSH data available.


Related in: MedlinePlus

An example of the clinical sample tested for IFNg and IL-10 sensitization to Merc/Thio exposure before and after removal of RFT.Notes: (A) and (C) IFNg and IL-10 levels in the clinical sample before removal of RFT (with RFT) and after removal of RFT (without RFT). (B) X-rays show initial findings with the VSCI values of three RFT and (D) the replacement of three RFT with ceramic implants in this patient.Abbreviations: Merc/Thio, mercaptan and thioether; RFT, root-filled teeth; VSCI, volatile sulfur compound indicator; IFNg, interferon gamma.
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f7-ijgm-8-109: An example of the clinical sample tested for IFNg and IL-10 sensitization to Merc/Thio exposure before and after removal of RFT.Notes: (A) and (C) IFNg and IL-10 levels in the clinical sample before removal of RFT (with RFT) and after removal of RFT (without RFT). (B) X-rays show initial findings with the VSCI values of three RFT and (D) the replacement of three RFT with ceramic implants in this patient.Abbreviations: Merc/Thio, mercaptan and thioether; RFT, root-filled teeth; VSCI, volatile sulfur compound indicator; IFNg, interferon gamma.

Mentions: The following case documents the integrated procedure of measuring local toxins with VSCI and the relevance of these measurements to systemic sensitization; the risk of an immunological trigger was determined from elevated IL-10 and IFNg values, and the monitoring of treatment was also performed. The patient (Ms SH; 60 years of age) described her medical history as follows: Hashimoto’s thyroiditis for about 6 years; rheumatoid arthritis for about 3 years; pigment abnormalities all over her body; and various allergies (eg, to methyl methacrylate). Figure 7 shows the initial X-ray findings with the VSCI values of the three RFT, and the lower X-ray is taken following both the extraction of the RFT and their replacement with nontoxic ceramic implants.


Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically treated teeth.

Lechner J, von Baehr V - Int J Gen Med (2015)

An example of the clinical sample tested for IFNg and IL-10 sensitization to Merc/Thio exposure before and after removal of RFT.Notes: (A) and (C) IFNg and IL-10 levels in the clinical sample before removal of RFT (with RFT) and after removal of RFT (without RFT). (B) X-rays show initial findings with the VSCI values of three RFT and (D) the replacement of three RFT with ceramic implants in this patient.Abbreviations: Merc/Thio, mercaptan and thioether; RFT, root-filled teeth; VSCI, volatile sulfur compound indicator; IFNg, interferon gamma.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4362895&req=5

f7-ijgm-8-109: An example of the clinical sample tested for IFNg and IL-10 sensitization to Merc/Thio exposure before and after removal of RFT.Notes: (A) and (C) IFNg and IL-10 levels in the clinical sample before removal of RFT (with RFT) and after removal of RFT (without RFT). (B) X-rays show initial findings with the VSCI values of three RFT and (D) the replacement of three RFT with ceramic implants in this patient.Abbreviations: Merc/Thio, mercaptan and thioether; RFT, root-filled teeth; VSCI, volatile sulfur compound indicator; IFNg, interferon gamma.
Mentions: The following case documents the integrated procedure of measuring local toxins with VSCI and the relevance of these measurements to systemic sensitization; the risk of an immunological trigger was determined from elevated IL-10 and IFNg values, and the monitoring of treatment was also performed. The patient (Ms SH; 60 years of age) described her medical history as follows: Hashimoto’s thyroiditis for about 6 years; rheumatoid arthritis for about 3 years; pigment abnormalities all over her body; and various allergies (eg, to methyl methacrylate). Figure 7 shows the initial X-ray findings with the VSCI values of the three RFT, and the lower X-ray is taken following both the extraction of the RFT and their replacement with nontoxic ceramic implants.

Bottom Line: Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether.Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells.The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Integrative Dentistry, Munich, Germany.

ABSTRACT
Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings are correlated with semiquantitative values of a VSC indicator applied directly on endodontically treated teeth. Data elucidate the role of VSC in patients with immunologic diseases and the role of a semiquantitative chairside test, like the VSC indicator presented here, in correlation to IFNg and IL-10 sensitization in peripheral blood mononuclear cells. The association between ex vivo-stimulated cytokines and endodontically derived sulfur components is supported by the fact that the number of interferon gamma- and/or interleukin-10-positive sensitized patients declined significantly 3-8 months after extraction of the corresponding teeth.

No MeSH data available.


Related in: MedlinePlus